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《Chinese Journal of Gerontology》 2006-08
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Promotion effect of pyrroloquinoline quinone on the growth of rat cortical neurons cultured in vitro

XIONG Shun-Hua,GONG Jian,WANG Jun,et al.Department of Physiology,Yunyang Medical College,Shiyan 442000,Hubei,China  
Objective To investigate the promotion effect of pyrroloquinoline quinine(PQQ) on the growth of cortical neurons cultured in vitro.Methods Cortical neurons were primarily cultured in vitro to observe the effect of PQQ on the development of neurite and soma and survival rate of cortical neurons,and to detect MTT metabolic rate and the protein expression of c-fos by immunohistochemical staining.Results The length of neurite and the maximum diameter of soma in PQQ group were longer than those of control group markedly.PQQ increased the survival rate of neurons and MTT metabolic rate.The optical densities of Nissl body and c-fos expressions were markedly higher than those of control group.Conclusions PQQ could improve the growth and development of cortical neurons cultured in vitro and enhance the survival rate and prolong the survival time.
【Key Words】: Pyrroloquinoline quinone(PQQ) Cortical neurons Growth
【Fund】: 湖北省教育厅重点项目(2003A011)
【CateGory Index】: Q58
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