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《Chinese Journal of Gerontology》 2007-12
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Effects of the β-asarone on learning and memory ability and SOD,GSH-Px and MDA levels in AD mice

JIANG Yong,FANG Yong-Qi,ZOU Yan-Yan.Central Lab of First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,Guangdong,China  
Objective To investigate the effects of β-asarone on the learning and memory ability,SOD,MDA and GSH-Px levels in Alzheimer disease(AD)mice's serum.Methods The effects of β-asarone on AlCl3 injured AD mice model were determined by observing the behavior change in water maze test and detecting SOD,MDA and GSH-Px levels.Results ①The swimming time and error times significantly decreased in β-asarone groups compared to those in model group.②Serum SOD and GSH-Px level decreased significantly while MDA increased remarkably in model group compared with those in normal control group(P0.01).Serum SOD,GSH-Px activity and MDA content in β-asarone group at dose of 1.06 mg·100 g-1·d-1 had no significant changes compared with those in normal control group;but there was significant difference between β-asarone groups and model group(P0.05 or P0.01),having no dose-dependency in the set dose ranges.Conclusions β-asarone could improve the ability of learning and memory ability,increase the content of SOD and GSH-Px and decrease MDA content in AD mice.It may be one of the mechanisms of β-asarone preventing and treating AD through regulating the freedom radical metabolism and improving antioxygenation.
【Fund】: 广东省自然科学基金项目(04300378);; 广东省中医药管理局科研项目(2040007)
【CateGory Index】: R749.16
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