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《Chinese Journal of Gerontology》 2009-03
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Increased expression of PKA and CREB1 in substantia nigra of Parkinson's disease mice by electroacupuncture therapy

YIN Hai-Yan,TANG Yong,CHEN Jin,et al. Acupuncture & Tuina School,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,Sichuan,China  
Objective To determine whether electroacupuncture (EA) treatment increase the expression of protein kinase A (PKA) and cAMP response element binding protein (CREB1)in substantia nigra (SNC) of Parkinson's disease (PD) mice. Methods 24 male mice (C57BL/6J) were averagely and randomly divided into control,control EA,model and EA groups. PD model mice were induced by i.p. 1-methyl,4-phenyl-1,2,3,6 tetrahydropyridine. The mice were treated by EA with frequency from 2 to 100 Hz,volt arrange from 2 to 4 V,pointed on Hegu (LI4) and Taichong (LV3) every day. After 21 times treated,the mice were killed to detect the expression of PKA and CREB1 by immunohistochemistry. Results The OD value of PKA and CREB1 were decreased in model group than those in control group (P0.05),and those in EA group were increased than those in model group(P0.01).Conclusions EA therapy could increase the expression of PKA and CREB1 in PD mice SNC.
【Fund】: 国家中医药管理局资助课题(国中医药科02-03JP41)
【CateGory Index】: R245
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