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《Chinese Journal of Gerontology》 2009-04
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Effects of acanthopanacis senticosi polysaccharides on expression of OGG1 mRNA in hippocampal neurons damaged by oxidative stress

DIAO Bo,TANG Ying,YANG Li,et al.Department of Medicine Experiment,Wuhan General Hospital in Guangzhou Military Region,Wuhan 430070,Hubei,China  
Objective To research the effects of acanthopanacis senticosi polysaccharides(ASPS) on expression of OGG1 mRNA in hippocampal neurons damaged by oxidative stress and provide experimental evidence for revealing the antioxidative stress injury effect of ASPS.Methods The oxidative stress injury cell model was induced by H2O2.The change of cell morphology was observed.The activity of hippocampal neurons was detected with MTT method.The vitalities of superoxide dismutase(SOD) and glutathion peroxidase(GSH-Px) were detected by chemical colorimetry.The expression of OGG1 mRNA was detected by RT-PCR.Results Compared with model group,the morphology damage of hippocampal neurons were slighter,and the activities of hippocampal neurons in ASPS group(0.46) were higher than those of model group(0.36)(P0.01).The vitalities of SOD and GSH-Px in ASPS group were higher than those in model group.ASPS obviously raised the expression of OGG1 mRNA.Conclusions ASPS can enhance the expression of OGG1 mRNA and protect the hippocampal neurons from oxidative stress injury.
【Fund】: 湖北省科技攻关计划(2006AA412C08)
【CateGory Index】: R285.5
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