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《Chinese Journal of Gerontology》 2009-12
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Effect of spirulina kinase extract on thrombus formation

CHEN Gao-Si,LI Xiao-Hua,PANG Hui,et al.Department of Physiology,Guangxi Medical University,Nanning 530021,Guangxi,China  
Objective To observe the effect of Spirulina kinase(SPK) extract on thrombus formation.Methods The clotting time of rabbit was tested by tube model in vitro.The venous thrombus models were established by ligating the inferior vena cava in aging rats in vivo.The thrombuses were weighed,and the coagulation time(CT) was measured by capillary method and the bleeding time(BT) was measured by cutting the rats tail.Results The SPK extract could significantly extend the time of CT,alleviate the weight of venous thrombus,prolong the time of BT.The effects had significant does-dependence.Conclusions The SPK extract has obvious effects of anticoagulation.
【Fund】: 广西科学研究与技术开发计划项目(No桂科攻0719006-2-27);; 广西自然科学基金(桂科学No.0991137)
【CateGory Index】: R285.5
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