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《Chinese Journal of Gerontology》 2009-12
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The effects of bushenfang,huoxuefang,and bushenhuoxuefang on praxiology and free radical metabolism in hippocampi of vascular dementia mice

Yü Wen-Tao,ZHANG Yi-Xin,WU Zhong-Qiu,et al.College of TCM,Hebei Medical University,Shijiazhuang 050091,Hebei,China  
Objective To probe the effects of bushenfang,huoxuefang,and bushenhuoxuefang on the abilities of learning and memory and free radical metabolism of vascular dementia(VD) mice.Methods The models of VD mice were established by cerebral ischemia reperfusion,the praxiological changes were observed by water maze and the activity of superoxide dismutase(SOD) and the content of malondialdehyde(MDA) in hippocampi were measured.Results Compared with those in normal group,the abilities of learning and memory in VD model mice were reduced,which showed extending the time for swimming the whole process,and increasing the time of mistakes(P0.01),and the activity of SOD in hippocampi was decreased and the content of MDA was increased(P0.01).Compared with those in model group,the learning and memory performance records were improved(P0.01),and the activity of SOD was increased and the content of MDA was decreased(P0.05 or P0.01) in hippocampi in each treatment group. The efficacy of bushenhuoxue group was more excellent than that of other treatment groups(P0.05 or P0.01).Conclusions The bushen,huoxue,and bushenhuoxue traditional Chinese medicine could improve free radical metabolism and the learning and memory capabilities,and the two kinds of traditional Chinese medicine have synergistic actions.
【Fund】: 河北医科大学博士基金资助项目(No.2006);; 河北省中医药管理局科学研究计划资助项目(No.2008010);; 河北省科技支撑计划资助项目(No.09276103D-2)
【CateGory Index】: R285.5
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