Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Gerontology》 2009-12
Add to Favorite Get Latest Update

The effects of bushenfang,huoxuefang,and bushenhuoxuefang on praxiology and free radical metabolism in hippocampi of vascular dementia mice

Yü Wen-Tao,ZHANG Yi-Xin,WU Zhong-Qiu,et al.College of TCM,Hebei Medical University,Shijiazhuang 050091,Hebei,China  
Objective To probe the effects of bushenfang,huoxuefang,and bushenhuoxuefang on the abilities of learning and memory and free radical metabolism of vascular dementia(VD) mice.Methods The models of VD mice were established by cerebral ischemia reperfusion,the praxiological changes were observed by water maze and the activity of superoxide dismutase(SOD) and the content of malondialdehyde(MDA) in hippocampi were measured.Results Compared with those in normal group,the abilities of learning and memory in VD model mice were reduced,which showed extending the time for swimming the whole process,and increasing the time of mistakes(P0.01),and the activity of SOD in hippocampi was decreased and the content of MDA was increased(P0.01).Compared with those in model group,the learning and memory performance records were improved(P0.01),and the activity of SOD was increased and the content of MDA was decreased(P0.05 or P0.01) in hippocampi in each treatment group. The efficacy of bushenhuoxue group was more excellent than that of other treatment groups(P0.05 or P0.01).Conclusions The bushen,huoxue,and bushenhuoxue traditional Chinese medicine could improve free radical metabolism and the learning and memory capabilities,and the two kinds of traditional Chinese medicine have synergistic actions.
【Fund】: 河北医科大学博士基金资助项目(No.2006);; 河北省中医药管理局科学研究计划资助项目(No.2008010);; 河北省科技支撑计划资助项目(No.09276103D-2)
【CateGory Index】: R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 2 Hits
1 WANG Xiaoyan,WANG Xiangming,WANG Danqiao*,LI Lianda,NIU Xiaohong (Experimental Research Center,China Academy of Chinese Medical Sciences,Beijing 100700,China);Effect of Ligusticam chuanxiong extract on lifespan of Caenorhabditis elegans and its underlying molecular mechanisms[J];China Journal of Chinese Materia Medica;2010-08
2 WANG Xiaoyan,WANG Xiangming,WANG Danqiao*,LI Lianda,NIU Xiaohong (Experimental Research Center,China Academy of Chinese Medical Sciences,Beijing 100700,China);Expression changes of age-related genes in different aging stages of Caenorhabiditis elegans and the regulating effects of Chuanxiong extract[J];China Journal of Chinese Materia Medica;2010-12
【Citations】
Chinese Journal Full-text Database 2 Hits
1 Xu Qiuping; Li Yungu;Jiang Aihua;Guan Wangdong and Wang Hedong(Teaching and Research Section of Pharmacology, Beijing University of TCM, Beijing 100029);Establishing of Mouse Learning and Memory Disfunction Model by Cerebral Ischemic Reper fusion and the Relevant Protecting Effect of Yinao Granules[J];JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE;1996-06
2 Chen Bing,Hu Guo qiang,Lü Gui ze,Chen Da quan,Chen Yu lan,First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;Effect of qichang zhitan oral solution on superoxide dismutas and malondialdehyde of brain tissue in rats with ischemia-reperfusion injury[J];Chinese Journal of Clinical Rehabilitation;2005-17
【Co-citations】
Chinese Journal Full-text Database 8 Hits
1 Yang Mu-xiang,Wu Chang-sheng,Yu Wen-tao,Hu Jin-kuan(Chinese Medical College, Hebei Medical University, Hebei 050091);Influence of Xingnaoqizhi Capsules on AChE of hippocampal tissue in mice with vascular dementia[J];Journal of Beijing University of Traditional Chinese Medicine;2006-03
2 DAI Yun; XIA Xiang(Ruijin Hospital Affiliated to Shanghai Second Medical University);Study Progress in Cerebrovascular Dementia in Chinese Medicine[J];ACTA UNIVERSITATIS TRADITIONIS MEDICALIS SINENSIS PHARMACOLOGIAEQUE SHANGHAI;1999-04
3 XU Jing-hua 1, YU Qing-hai 1, WATANABE Hiroshi 2 (1.School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China; 2. Department of Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, 930-0194, Japan);Improving Effects of Huanglian-Jiedu-Tang on Learning and Memory in Animals Subjected to Cerebral Ischemia and Its Mechanisms[J];LiShiZhen Medicine and Materia Medica Research;2002-12
4 ZHOU Zheng -guo,QU Fang,SHAN Li -hua,et al (Dalian Hospital of Integrated Traditional and Western Medicine,Dalian 116011,Liaoning,China);Clinical Study on"Yiqi Huatan Method"in Treating"Tanzhuo Zuqiao Symptom"Vascular Dementia[J];Journal of Practical Traditional Chinese Internal Medicine;2010-02
5 Kou Jouping, Hua Min, Zhu Danni, Yan Yongqing(Department of Chinese Complex Prescription, China Pharmaceutical University, Nanjing 210038,China);Effect of DSS on the memory dysfunction induced by ischemia reperfusion in mice[J];Chinese Journal of Modern Applied Pharmacy;2001-05
6 XIN Qin,LIU Shan-ting,GE Shun,WANG Chuan-gong,ZHANG Xin,XU Hong-kai (Department of Pharmacology,Jining Medical College,Jining SHA NDONG 272013,China);Promotion effect of telmisartan on memory deficit induced by brain ischemic reperfusion in mice[J];Chinese Journal of New Drugs and Clinical Remedies;2006-09
7 ZHENG Su-xia1,LI Shi-ying1,ZHNG Wen-yi2(1.Handan Traditional Chinese Medical Hospital,Handan 056001,Hebei,China;2.Weixian County Huilong Town Health Center,Weixian 056000,Hebei,China);Effect of Danggui Shaoyao-San on Oxidation Damage in Hippocamp of Vascular Dementia Mice[J];Chinese Archives of Traditional Chinese Medicine;2008-10
8 Xu Jinghua, Yu Qinghai, Li Lizhi (School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016);Study on the antioxidation effects of extract of Huanglianjiedutang (黄连解毒汤) in cerebral ischemic mice[J];Pharmacology and Clinics of Chinese Materia Medica;2002-06
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Lu Yanwan(Department of Neurology,the Jiaozuo People Hospital,Henan Province 454000)Li Zuoxiao(Department of Neurology,Affiliated Hospital of Luzhou Medical College 646000);Influence of Congling Capsule on Oxygen free Radical of Rats with Vascular Dementia[J];Guangming Journal of Chinese Medicine;2008-10
2 SUN Wei-ya.Department of Neurology,Heze Municipal Hospital,Heze 274031,China;The Observation of SS,AVP,β-EP and NSE in CSF of Patients with Vascular Dementia[J];Neural Injury and Functional Reconstruction;2007-01
3 LI Li-juan,LI Hong-xia,WU Xin-tong,YAN Bo,ZHOU Dong. Department of Neurology,West China Hospital,Sichuan University,Chengdu 610041,China;Effect of Geniposide on Vascular Dementia in Rats[J];Journal of Sichuan University(Medical Science Edition);2009-04
4 TCM College, Hebei Medical University WANG Ya-li NIU Bing HOU Xian-ming et al(Shijiazhuang 050091);Comparative Studyof Effects on Learning Memory, NO and NOS of Vascular DementiaRats of Different Combinations of Kidney-invigorating, Blood-promotingand Phlegm-dissipating[J];Journal of Hebei Traditional Chinese Medicine and Pharmacology;2006-01
5 WANG Xue-jing,WANG Wei-bin,ZHANG Xiao-xia(No.1 People's Hospital Affiliated to Jining Medical College,Jining,Shandong,272111);Effect of hyderine to the activity of acetylcholine system in hippocampus of mice with vascular dementia[J];Journal of Jining Medical College;2009-03
6 Tian Jinzhou ; Wang Yogyan ; Judy Haworth; et al.( The Affiliated Dowgzhimen Hospital, Beijing university of TraditionalChinese Medicine, Beding 100700)( Beoing University of Traditional Chinese Medicine, Beijing 100029)( Blackberry Hill Hospital, univers;The Review of Research on Vascular Dementia[J];JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE;1997-04
7 ZHANG Xin,ZHANG Yu,SUN Rong,et al(Department of Neurology,First Hospital of Jilin University,Changchun 130021,China);Effects of APP17-mer peptide on capability of memory and expression of Bcl-2 and Bax protein in hippocampus of cerebral ischemia rats[J];Chinese Journal of Geriatric Heart Brain and Vessel Diseases;2007-05
8 XIE Daojun,JIANG Tingzhan,WANG Yuanjin,HU Yebing,LI Zhihe,HUANG Wei,YIN Liangsheng,LIU Ni,CAO Shijian,CHEN Yonghua(Department of Neurology,The First Affiliated Hospital of Anhui College of Traditional Chinese Medicine,Hefei 230031,China);Effects of huangpu tongqiao capsule(HTC) on protein expressions of fas and fasL in neurons of rats with vascular dementia[J];Chinese Journal of Clinical Healthcare;2007-06
9 YUAN Fenglian,ZHANG DongmeiEEG Room,Linyi people’s Hospital ,Linyi(276001), Shandong China;The effect of ERP and EEG in assessing the donepezil to treat vascular dementia[J];Journal of Clinical Electroneurophysiology;2008-06
10 JI Xu-ming~1,DU-Fang~2(1.Shandong University of TCM,Jinan 250014,China;2.encephalopathic Institute of Qingdao University,Qingdao 266033,China);Effect of Kangnaoling capsule on expression of NMDA receptor and calcium overload in nerve cell of VD rat[J];Journal of Shandong University of Traditional Chinese Medicine;2006-04
【Secondary Citations】
Chinese Journal Full-text Database 9 Hits
1 Zhao Xianlin, Li Dongpei, Fang Xiubin, Yang Guorui (Department of Neurosurgery, The First Clinical College, China Medical University, Shenyang, 110001);Ultrastructural Study on the Hippocampal Neurons of Vascular Dementia in Rats[J];PROGRESS OF ANATOMICAL SCIENCES;2000-02
2 ZHAO Xiao Zhen,WANG Wei,KANG Zhong Han,WU Yi Qin,XU Jian Wen,CHEN Chun Peng,ZHONG Xiu Rong (Department of Anatomy,Fujian Medical University,Fuzhou 350004,Fujian);Changes of the hippocampal synaptic structural parameters in vascular dementic rats[J];Chinese Journal of Anatomy;2002-01
3 DENG Juan,ZHOU Hua-dong,ZHANG Li-li,et al.Daping Hospital,Third Military Medical University,Chongqing 400042,China;The effect of Bcl-2protection on neu ronal DNA damage after cerebral isch emia and reperfusion[J];Modern Rehabilitation;2002-15
4 FAN Wen-hui,LI Lu-si,LIU Zhi-rong.Southwest Hospital,Third Military Medical University,Chongqing 400038,China;An animal model of vascular dementia,its pathological basis and cholinergic mechanism[J];Modern Rehabilitation;2002-21
5 Xia Shumeng,Zhang Dechen,Wu Xiaoji ng,Yu Weijiang,Shi Xinpo,Chen Lifang,Zheng Ge,Department of Anestheiology,466th hospital of PLA,Beijing 100089,China;The effects of ischemia-reperfusion injury on life activities of skeletal muscle cells[J];Modern Rehabilitation;2003-08
6 Yan Wei;Xu Erhe;Zhang Yun.(Department of Neurology, Second Teaching Hospital, Bethune Norman University of Medical Sciences, Changchun 130041);Red blood cell immune adherence with the dynimic changes of free radical metabolism in the acute cerebral infarct patients[J];JOURNAL OF APOPLEXY AND NERVOUS DISEASES;1996-04
7 /Li Wei;Yan Huijin;Zhao Huimin;//;Protective effect of drug and influence of cerebral ischemia reperfusion on learning and rememberance in mice[J];CHINESE JOURNAL OF REHABILITATION MEDICINE;1995-02
8 Shan Shaojie ,Xu Qiuping(Department of Pharmacology. Beijing College of Traditional Chinese Medicine,Beijing 100029);Effect of Yi Zhi Jiaonang on Learning and Memory in Mice and PossibleMechanisms Involed in Its Actions[J];PHARMACOLOGY AND CLINICS OF CHINESE MATERIA MEDICA;1994-01
9 Tang Minke; Xu Qiuping; Tang Yipeng; Cheng Lihua(Department of Pharmacology, Beijing University of TCM, Beijing 100029);Protective Effect of Yi Nao Chong Ji on Cerebral Ischemia[J];PHARMACOLOGY AND CLINICS OF CHINESE MATERIA MEDICA;1996-01
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved