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《Chinese Journal of Gerontology》 2009-24
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The study of methylmercury inducing apoptosis in NCI-H446 cell in vitro

DING Hui,WANG Jian-Guo,LI Dan,et al.Department of Respiration,the First Hospital of Jilin University,Changchun 130021,Jilin,China  
Objective To investigate the possible mechanism of methylmercury(MMC)inducing apoptosis in human small cell lung cancer NCI-H446.Methods The expressions of Bcl-2,Bax and caspase-3 in NCI-H446 cells were detected by RT-PCR.Results The mRNA level of Bcl-2 in MMC group was lower than that of control group,and had time dependence,was the minimum at 24 h.The mRNA levels of Bax and caspase-3 in MMC group were higher than those of control group,and had time dependence,were the maximum at 24 h.Conclusions MMC could induce NCI-H446 cells apoptosis in vitro.
【Fund】: 国家自然科学基金资助(39770655 30070645);; 长春市科技局资助(2006036)
【CateGory Index】: R73-3
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