Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Gerontology》 2012-22
Add to Favorite Get Latest Update

Effects of gypenosides on the hippocampal cholinergic system in D-galactose induced Alzheimer's disease in mice

ZHOU Wei-Hua,TAN Li-Ming,MI Chang-Zhong,et al. Jishou University School of Medicine,Jishou 416000,Hunan,China  
Objective To investigate the effects of gypenosides on the hippocampal cholinergic system in D-galactose induced Alzheimer's disease(AD) in mice.Methods The mice were given subcutaneous injection of 10% D-galactose for 6 weeks(125 ml·kg-1·d-1).Normal saline,gypenosides respectively were given by intragastric administration in different study groups.The mice were trained to find the platform in the water maze on the 43th day.After 24 hours,learning and memory ability was tested,choline acetyltransferase(chAT) activity,acetylcholinesterase(AchE) activity,the expression of ChAT in hippocampus was observed by Western blotting after treatment.Results Compared with the normal control group,the learning and memory dysfunction,the decreases of ChAT activity and expression of ChAT were found in model group,AchE activity was increased in model group(P0.05,P0.01).The gypenosides could markedly attenuate cognitive dysfunction,elevate ChAT and expression of ChAT,decrease AchE activity in the hippocampi of mice treated with D-galactose(P0.05,P0.01).Conclusions The gypenosides can significantly improve the hippocampal cholinergic system function,and thus enhance the learning and memory ability in D-galactose induced AD model mice model.
【Fund】: 湖南省科技厅基金项目(2011TJ3202);; 湘西州科技局课题项目(2009zd06)
【CateGory Index】: R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 4 Hits
1 Deng Jiagang,Du Zhengcai,Hao ErweiGuangxi Traditional Chinese Medical University,Nanning Guangxi 530001;Effect of Compound Jiao Gu Lan Medicines on Memory and Brain Monoamine Oxidase Activity of Mice[J];World Journal of Integrated Traditional and Western Medicine;2007-12
2 ZHANG Xiao-yu,LI Yan,YONG Bin,LIU Jian-ting,YAN Wei* (College of Life Science, Sichuan Normal University, Chengdu 610068, China);Study on Gynosaponins Compound on Ameliorating Memory in Mice[J];Food Science;2007-03
3 MIAO Ming-San,MA Xiao,ZHANG Guang-Wei,et al.Henan College of Traditional Chinese Medicine,Zhengzhou 450008,Henan,China;Effect of Schisandra Chinensis baill distilled by ethanol on acetylcholinesterase,neurotransmitter in aging mice model induced by D-galactose[J];Chinese Journal of Gerontology;2010-15
4 LU Ying-ying,GAO Liang-cai,YUAN Chong-gang(School of Life Sciences,East China Normal University,Shanghai 200062,China);Evaluation on Alzheimer-like Disease Model Induced by D-galactose and Expression of Galanin in the Hippocampus[J];Chinese Journal of Neuroimmunology and Neurology;2007-04
Chinese Journal Full-text Database 10 Hits
1 ;复方绞股蓝益智颗粒急性毒性与慢性毒性实验研究[J];Contemporary Medicine;2012-19
2 ZHANG Tao1,YUAN Di-shun2(1.Agricultural Product Quality Institute,Fujian Agriculture and Forestry University,Fuzhou 350002,China;2.Institute of White Tea,Fujian Agriculture and Forestry University,Fuzhou 350002,China);Effective Components of Gynostemma pentaphyllum and Research Advances in Gypenosides[J];Acta Agriculturae Jiangxi;2008-09
3 FAN Yu-shan,CHEN Mang-hua,ZHAO Cai-jiao(The Acupuncture and Moxibustion Faculty of Guangxi Traditional Chinese Medicine University,Nanning 530001,Guangxi,China);Effect of Hippocampus Cholinesterase for Alzheimer's Disease Model Treated by the Shallow Acupuncture to Regulate the Governor Meridian[J];Liaoning Journal of Traditional Chinese Medicine;2008-12
4 JI Li-li;WANG Wen-lan;Derpartmet of postgraduate 2007,Inner Mongolia Medical College;Inner Mongolia Hospotal,Department of Pediatrics;;Progress of Relationship Between Galanin And Epilepsy[J];Inner Mongolia Medical Journal;2009-S4
5 Zhang Chun1,Wang Shizhen2,Wang Tie1(1.Department of Nuclear Medicine,Beijing Chaoyang Hospital,Capital Medical University;2.Department of Nuclear Medicine,PUMC Hospital,CAMS and PUMC);Effects of Tetramethylpyrazine on the Hippocampal Cholinergic System in D-galactose Induced Mice Model with Alzheimer's Disease[J];Journal of Capital Medical University;2008-01
6 XU Xian-xiang,WU Yang-zheng(Institute of Molecular Medicine,Huaqiao University,Quanzhou 362021,China);Review of delaying senility effects of saponins[J];Science and Technology of Food Industry;2012-11
7 ZHOU Jian-hua, ZHANG Xing-ya (College of Life Science, Shandong Normal University, Jinan 250014);New research progress of Gynostemma pentaphyllum and application[J];Food Science and Technology;2010-02
8 HONG Xiu-yun,WU Xiao-ying,YE Chun-yan(College of Bioscience and Bioengineering,South China University of Technology,Guangzhou 510006,China);Extraction of Gypenosides under the Intergrated Ureatment with Ultrasonic and Cellulase[J];Biotechnology;2010-06
9 ZHANG Dan*,YANG Chun(*Department of Nuclear Medicine,Wuhan General Hospital of Guangzhou Military Command,Wuhan 430070,China);Progress in research on galanin receptor-2[J];Chinese Journal of Biologicals;2012-01
10 Peng Zhao,Si Yu Yao,Bin Li,Rong Zhen Liu,Feng Wen Li,Wei Tao He, Yan Wu WangPeng Zhao,Si Yu Yao,Bin Li,Rong Zhen Liu,Feng Wen Li,Wei Tao He, Yan Wu Wang,Department of Health Toxicology and Functional Laboratory, Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention,Nanning 530021,Guangxi Zhuang Autonomous Region,China;Effect of saponin in protecting against alcoholic liver injury[J];Chinese Journal of Clinical Rehabilitation;2004-30
Chinese Journal Full-text Database 10 Hits
1 LIU Xia,WANG Ping-jun,Xu Fu-xin (The Frist People's Hospital of Wuhu,Anhui Wuhu 241000,China);STUDY ON GYPENOSIDES INHIBITING NEOPLASM GROWTH AND ELEVATING IMMUNOLOGICAL FUNCTION IN LEWIS LUNG CANCER OF MICE[J];Journal of Anhui Traditional Chinese Medical College;2001-01
2 HOU De-ren, YANG Qi-dong, ZHOU Lin, et al. Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China;Effect of Polygonum Multiflorum Thunb on Learning-memory Ability in Rats with Alzheimer Disease and Its Probable Mechanism[J];Journal of Chinese Physician;2004-03
3 LI Tuo,ZHAO Zhong-xin Department of Neurology,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China;β-amyloid and Alzheimer disease:recent progress[J];Academic Journal of Second Military Medical University;2010-10
4 Xia Ruohan, Liu Shengyuan, Wang Jianzhi (Department of Pathophysiology, School of Basic Medical Science, Tongji Medical University, Wuhan 430030 China);EFFECT OF INHIBITION OF PHOSPHATASES ON NITRIC OXIDE SYNTHASE ACTIVITY IN PC12 CELLS[J];Chinese Journal of Histochemistry and Cytochemistry;2001-01
5 Xu Ying,Liu Rong-fang,Xu Jian-wen,Yu Chang-xi(Department of Pharmacology,College of Pharmacy,Fujian Medical University,Fuzhou 350004,China);Level of PTEN protein in the process of tau hyperphosphorylation induced by okadaic acid in NG108-15 cells[J];Strait Pharmaceutical Journal;2007-10
6 YANG Mei,CAI Fang,WANG Rui-shan,PAN Qian,LONG Zhi-gao,DENG Xiao-yun,XIA Kun~(*),XIA Jia-hui,ZHANG Zhuo-hua(National Key Lab of Medical Genetics of China,Central South University,Changsha 410078,China);Identification and clone of human Alzheimer's disease related gene nicastrin promoter[J];Journal of Central South University(Medical Sciences);2006-01
7 DUAN Bing-Nan,CHENG Qin-lin(Department of Histology and Embryology of XiangYa Medical College of Central South University,changsha 410013,China);Effects of Gypenosides on Enzyme Activity and Phagocytic Capacity of Peritoneal Macrophage in Mice[J];Acta Academiae Medicinae Jiangxi;2007-03
8 LIU Qing-qing,WU Jing-dong(Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China);Effect of Extract of Gynostemma on Activities of SOD and Capacity of Inhibiting OH.in Blood of Naturally Senile Mice[J];Journal of Liaoning University of Traditional Chinese Medicine;2008-06
9 HU Jingqing,WEN Zehuai,LAI Shilong (Senile Encephalopathy Institute,Guangzhou University of TCM,Guanghou 510405, China);A Preliminary Study on the Memory Attribution and Methodology in Morris Water Maze Test[J];JOURNAL OF GUANGZHOU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE;2000-02
10 WU Lei1,CHEN Yunbo2,WANG Qi2,CHENG Shuyi2,LIANG Weixiong2,WEN Zehuai2(1.The Second Affiliated Hospital,Guangzhou University of TCM,Guangzhou 510405,China;2.DME Center,Institute of Clinical Pharmacology,Guangzhou University of TCM,Guangzhou 510405,China);In-Vitro Inhibitory Effect of Ginsenoside Rg1 on Aβ_(25-35)-Induced NG108-15 Apoptosis in alzheimer's Disease Cellular model[J];Journal of Guangzhou University of Traditional Chinese Medicine;2007-02
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Li Donghui Qiu Peilun Li Guangyuan Mu Qiyun (Dept. of Pharmacology, Xian Medical University);Effect of Gypenosides on Myocardial Ischemia/Reperfusion Injury in Rats[J];Basic Medical Sciences and Clinics;1990-01
2 WANG Yao-chun, WANG Zi-dong , SUN Li-ming, BAI Zhi-quan (Department of Physiology, Jinan University Medical College, Guangzhou 5120632,China);The Y-type maze test used in learning and memory of animal (A review)[J];Journal of Jinan University(Natural Science & Medicine Edition);2001-05
3 ZHANG Yong-kang,JIANG Jian-bo,CHEN Li-hua,WANG Yan,ZHOU Le-zhou (Department of Chemistry, Jishou University, Jishou 416000, Hunan China);Determination of the Unsaturated Fatty Acid of Actinidia Chinesis Planch Seed Oil[J];Journal of Jishou University(Natural Science Edition);2001-04
4 YangXinyu, Wang Jianguang, Li Xincheng, Zhang Tao, Bai Shuge (Basic medical college of Jiamusi university, 154002);Effect of Dazao on SOD activity and MDA content in the brain of D-galactose-induced senile mice[J];Heilongjiang Medicine and Pharmacy;2001-02
5 MENG Xiangli QU Fengyu SHEN Li ZHAO Yujia ( The College of Chemistry and pharmacy, Jiamusi University, Jiamusi 154007, China ;Wandashan Pharmaceutical Factory of Heilongjiang Province Mi Shan 158300,China);Effect of alcohol extract of Tianditang on the activity of SOD and the level of MDA of D-galactose-induced senile mice's brain[J];Heilongjiang Medicine and Pharmacy;2003-02
6 TAO Huiyu~1 TAN Xiaojing~1 LI Li~2 CHEN Jiebin~2 LI Shuangjie~2 (~1Department of Cardiology,~2Department of Paediatric,the First Affiliated Hospital of Nanhua University, Hengyang, 421001,China);Protective effects of Kiwi essence on myocardium injury induced by adriamycin in rat and its mechanism of action[J];Journal of Clinical Cardiology;2006-09
7 Tao Jianwu, Yao Caiping, Wang Jichun, Hao Guangli, Ye Zhengjun (The Central Laboratory,Hubei College of Pharmacy and Medical Laboratory Technology,Wu Han 430064);Inhibitory effects of gynostemma pentaphyllum on lipid peroxidation reaction in rats liver[J];Chinese Journal of Clinical Pharmacy;2001-03
8 HAO Jun, ZHAO Jianxiong Institute of Integrated Traditional Chinese and Western Medicine,Lanzhou Medical College,Lanzhou 730000;Effect of Jianshenbao on activity of SOD and content of MDA in serum of aged model mice[J];Journal of Lanzhou Medical College;2004-01
9 DUAN Yong-qiang,CHENG Rong,CHENG Ying-xia,WANG Dao-kun (Gansu College of Traditional Chinese Medicine,Lanzhou,730000,China);Effects of Dunhuang Shishi Dabao Capsule on levels of MDA,SOD in serum and GSH-Px in brain tissue of senile rats[J];Journal of Lanzhou Medical College;2005-02
10 SUO Guo-ling1,TANG Hong-li1,2,WANG Xiu-li1(1.School of Clinical Medicine,Southeast University,Nanjing 210009,China;2.Department of Pediatrics,Institute of Clinical Medical Research,Nanjing 210009,China);Influence of radix salviae miltiorrhizae on the learning and memory and level of AChE and ChAT in hippocampus of status epilepticus juvenil rats[J];Journal of Southeast University(Medical Science Edition);2007-04
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved