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Effects of gypenosides on the hippocampal cholinergic system in D-galactose induced Alzheimer's disease in mice

ZHOU Wei-Hua,TAN Li-Ming,MI Chang-Zhong,et al. Jishou University School of Medicine,Jishou 416000,Hunan,China  
Objective To investigate the effects of gypenosides on the hippocampal cholinergic system in D-galactose induced Alzheimer's disease(AD) in mice.Methods The mice were given subcutaneous injection of 10% D-galactose for 6 weeks(125 ml·kg-1·d-1).Normal saline,gypenosides respectively were given by intragastric administration in different study groups.The mice were trained to find the platform in the water maze on the 43th day.After 24 hours,learning and memory ability was tested,choline acetyltransferase(chAT) activity,acetylcholinesterase(AchE) activity,the expression of ChAT in hippocampus was observed by Western blotting after treatment.Results Compared with the normal control group,the learning and memory dysfunction,the decreases of ChAT activity and expression of ChAT were found in model group,AchE activity was increased in model group(P0.05,P0.01).The gypenosides could markedly attenuate cognitive dysfunction,elevate ChAT and expression of ChAT,decrease AchE activity in the hippocampi of mice treated with D-galactose(P0.05,P0.01).Conclusions The gypenosides can significantly improve the hippocampal cholinergic system function,and thus enhance the learning and memory ability in D-galactose induced AD model mice model.
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