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《Chinese Journal of Gerontology》 2015-05
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Expression and significance of Decorin in two human endometrial carcinoma cells cultured in vitro

DENG Shou-Heng;LI Lin-Jun;CAO Feng-Jun;Center of Oncology,People's Hospital Affiliated to Hubei University of Medicine;  
Objective To investigate the effects of RG alone or combined with RA on cell proliferation and Decorin expression in cultured two human endometrial carcinoma cells Ishikawa( PTEN-) and HEC-1A( PTEN +) in vitro.Methods After treated with RG alone or combined with RA for 24 hours,PCNA was measured to determine the proliferative inhibition effects of two inhibitors on tumor cells.The expression of Decorin m RNA and Decorin protein was measured by RT-PCR and Western blot respectively.Results In Ishikawa cells,RG alone or combined with RA could decrease cell PCNA positive rate and promote the expression of Decorin m RNA and protein abundance.The effect of RG combined with RA was better than that of RG alone.But in HEC-1A cells,the effects above were not obvious.Conclusions Loss of PTEN in endometrial carcinoma cells may inhibit the cell proliferation and promote the expression of Decorin m RNA and protein abundance,which due to the enhancing sensitivity of cells to related signal transduction inhibitors.
【Fund】: 湖北省教育厅项目(Q20092401);; 湖北医药学院创新团队项目(2008CXZ02);; 湖北省自然科学基金(2013CDZ011)
【CateGory Index】: R737.33
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【Citations】
Chinese Journal Full-text Database 8 Hits
1 DENG Shou-heng,WU Ya-ling,KE Xian-zhu,et al.Cancer Center,Affiliated People′s Hospital of Hubei Medical University,Shiyan 442000 China;Impact of Signal Transduction Inhibitors on Biological Behaviours of Two Human Endometrial Carcinoma Cell Strains in Vitro[J];Chinese General Practice;2011-20
2 CHEN Ping1, ZHOU Bao-feng2, CAO Feng-jun1, LI Fang1, XU Hua2, DENG Shou-heng1(1.Center of Oncology,People's Hospital,Hubei Medical University,Shiyan 442000,China;2.Shiyan Maternal and Child Health Hospital,Shiyan 442000,China);Enhancing Chemotherapy Sensitivity of Taxol for Human Endometrial Carcinoma Cells Through Simultaneously Targeted Blockade of Epidermal Growth Factor Receptor and mTOR Signaling Pathway[J];Lishizhen Medicine and Materia Medica Research;2011-12
3 Li Zhiwei1,Li Caihong2,Zhang Zhihui3,Xi Feng4 1The First Hospital of Handan City,Hebei Handan 056002,China;2Handan City Maternal and Child Health Hospital,Hebei Handan 056002,China;3Zunhua City People Hospital,Hebei Zunhua 064200,china;4Medical College of Hebei University of Engineering,Hebei Handan 056001,China.;PTEN protein expression and significance of P-AKTprotein in endometrial carcinoma[J];Journal of Modern Oncology;2013-03
4 YUAN Yuan,ZHOU Jing,JIANG Zheng.(Department of Gastroenterology,the First Affiliated Hospital,Chongqing Medical University,Chongqing 400016,China);Research Progress in the Biology of Decorin[J];Medical Recapitulate;2011-09
5 XIONG Run-qing,XU Xiang-fan,MA Duo,BAO Yan-ni,CHEN Liu-fei(Department of Ultrasonic Imaging,The NO.2 Hospital,Xiamen,Fujian 361021,China);Diagnotic Value of Transvaginal Sonography in Uterus Endometrial Lesions[J];Journal of Yunyang Medical College;2008-06
6 ZHOU Qing1,GUO Xian-yin2,YANG Xiao-xi1,CHEN Jian1 (1Department of Ophthalmology,The First Affiliated Hospital,Jinan University,Guangzhou 510632,China;2Department of Ophthalmology,Shilong People's Hospital,Dongguan 523320,China);Inhibitory effect of decorin on human pterygium fibroblasts in vitro[J];Chinese Journal of Pathophysiology;2012-05
7 DENG Shou-Heng,YU Xiong-Jie,CAO Feng-Jun,et al. Center of Oncology,Hubei Medical University Affiliated People′s Hospital,Shiyan 442000,Hubei,China;Effect of RG-14260 combined with Rapamycin on two human endometrial carcinoma cells in vitro[J];Chinese Journal of Gerontology;2012-01
8 DENG Shou-heng,SHI Jian-guo,KE Xian-zhu,CHEN Ping,LI Fang,SHI Xiao-yan*(Renming Hospital,Hubei Medical University,Shiyan 442000,China);Effect of mTOR Signal Transduction Pathway on Proliferation of Human Endometrial Carcinoma Cells Ishikawa in vitro[J];Chinese Journal of Experimental Traditional Medical Formulae;2011-12
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 CHEN Hua, WANG Zhi-hong, WANG Jia-Ii, et al (Lab center for preventive medicine, Fujian medical university, Fuzhou 350004, China; Center of disease control and prevention of Fujian province, Fuzhou 350001, China);Preliminary Study on Antioxidative and Antitumor Effect of Curcuma Longa L Fluid on H_(22) Tumorigenic Mouse[J];Carcinogenesis,Teratogenesis and Mutagenesis;2004-06
2 LIU Liang 1,2 ,ZHOU Shou-biao 1,ˇ ,ZHENG Wei-fa 2 (1.Provincial Key Laboratory of Conservation and Exploitation of Biological Resources in Anhui,Institute of Life Science,Anhui NormalUniversity,Wuhu Anhui241000,China;2.Provincial Key Laboratory of Biotechnology on Medical Plants,Xuzhou Jiangsu221116,China);Inhibition of Tumor Cells by Ethanol Extract of Fomes Fomentarius[J];Carcinogenesis,Teratogenesis and Mutagenesis;2005-02
3 LI Hong-wei1,2,WU Kun2,(1.Department of Preventive Medicine,Medical College,Xiamen University,Xiamen Fujian 365001,China; 2. Department of Nutrition and Food Hygiene,School of Public Health,Harbin Medical University,Heilongjiang 150001,China);Antineoplastic Effects of α-Tocopheryl Succinate in Ehrlich Ascitesocarcinoma Bearing Mice[J];Carcinogenesis,Teratogenesis & Mutagenesis;2006-05
4 SHEN Ye-shou,ZHENG Li-jun,WANG Zheng-liang,GU Li-ping(Laboratory of Glycoconjugate and Glycotechnology, Institute of Biochemistry and Microbiology, Anhui University, Hefei 230039,Anhui, China);Experimental Study on Anti-tumor Effects of Intracellular Polysaccharide from Phellinus Linteus[J];Carcinogenesis,Teratogenesis & Mutagenesis;2007-04
5 QIN Yan-jun,YAO Ri-sheng(School of chemical Engineering,Hefei University of Technology,Hefei 230009,China);Recent Progress in Prodrug of Camptothecin[J];Anhui Chemical Industry;2007-05
6 LU Jing-tao, WEI Wei,CHEN Min-zhu (Institute of Clinical Phurrnacology,Anhui Medical University,Hefei 230032);A preliminary tudy on antitumor activity of artimisinine[J];Anhui Medical and Pharmaceutical Journal;2007-01
7 XU Du-juan,CHEN Min-zhu (The Department of Pharmacy,the First Affiliated Hospital of Anhui Medical University,Anhui Hefei 230022, China);Protection of Total Astragalus Extract Against Chemotherapy-induced Leukopenia and Immunosuppression in Tumor Bearing Mice[J];Journal of Anhui Traditional Chinese Medical College;2006-03
8 LI Chun yi1,REN Wen long2,LI Chang ben3,et al.1.Department of Clinical Pharmjacology,Beijing Institute for Cancer Research, Beijing 100034,P.R.China2.Department of Pharmacology,Shanghai Institute of Pharmaceutical Industry,Shanghai 200437,P.R.China3.Th;The antitumor activity of recombinant human lymphotoxin[J];CHINESE JOURNAL OF CANCER;1999-04
9 JIANG Chao, QING Chen, MENG Ling hua, et al. Shanghai Institute of Material Medical,Chinese Academy of Sciences,Shanghai 200031,P.R.China;Inhibitory effects of China ganoderma lucid essence (CGLE) on DNA topoisomerases and its ability to induce apoptosis of K562 cells[J];CHINESE JOURNAL OF CANCER;1999-06
10 ZHAO Cheng-jun ; KONG Fan-yuan; HU Qing-he, et al.(Central Laboratory, Ningxia Medical College, Yinchuan 750004, P. R. China);Apoptosis of glioblastoma multiforme cells induced by VM-26 treatment in vitro[J];CHINESE JOURNAL OF CANCER;2000-07
China Proceedings of conference Full-text Database 5 Hits
1 LI Hongwei (Department of Preventive Medicine, Medical College, Xiamen University, Xiamen Fujian 365001, China);Experimental Study on Prolonging Life Effect of α-Tocopheryl Succinate in Ehrlich Ascitesocarcinoma Bearing Mice[A];[C];2008
2 ;吴茱萸碱对人肝癌细胞 HepG2的生长抑制及诱导凋亡作用[A];[C];2008
3 ZHANG Jin-lin,NI Mei-xin,LIU Jin-bing,SHEN Kang,ZHANG Yi-xin Affiliated Tumor Hospital of Nantong University,Nantong 226361,China;Influence of Bu Kang Ling on chemotherapy effects and immune function in mice bearing Lewis lung cancer[A];[C];2010
4 (Department of pharmacognosy,Medical College of Chinese People's Armed Police Forces,Tianjin 300162,China);YB-13,a novel synthetic microtubule inhibitor,induces apoptosis of SKOV3 cells and its antitumor activity in vivo[A];[C];2008
5 Xue Ying,Chen Hang Beijing Center for Disease Control and Prevention,Beijing 100013,China;Study on the anti-carcinogenic effects of three compounds in Kaempferia galanga L[A];[C];2002
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 HUANG Hai hui, LIANG Hou jie, HU Shao yi, BIAN Zhi heng, HE Jian ming (Department of Oncology, Southwest Hospital, Third Medical Military University, Chongqing 400038, China);Effects of PI3K pathway on multicellular resistance of lung adenocarcinoma A549 cells via affecting cell apoptosis[J];Acta Academiae Medicinae Militaris Tertiae;2004-09
2 SHEN Yuan1,HU Hai-yan2,LU Lin3 1Department of Gynecology and Obstetrics,The First Affiliated Hospital of Jinan University,Guangzhou 510630,China;2Department of Hemotology,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,China;3Department of Gynecology and Obstetrics,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China;Mechanism of bortezomib in inducing apoptosis and improving chemosensitivity of Ishikawa cells[J];Journal of Southern Medical University;2010-06
3 ZHAO Lijun,WEI Lihui,LIU Ning,et al.(Department of Gynecology,Peking University People's Hospital,Beijing 100044,China);The change of the growth and signal pathway after PTEN gene knocked down in HEC-1A cells[J];Chinese Journal of Clinical Obstetrics and Gynecology;2008-03
4 GUO Ruixia1),WEI Lihui2),SHI Huirong1),ZHOU Yan1),LIU Yanjie1),WANG Jianliu2),QIAO Yuhuan1)1)Department of Obstetrics and Gynecology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052 2)Department of Obstetrics and Gynecology,People's Hospital,Peking University,Beijing 100044;Expression of PTEN protein and phosphorylated protein kinase B in endometrial adenocarcinoma tissue[J];Journal of Zhengzhou University(Medical Sciences);2010-01
5 WU Xiao-nan.Medical Oncology,Beijing Hospital,Beijing 100730,China;EGFR Gene Mutation and Its Clinical Significance in Tumors[J];Chinese General Practice;2008-13
6 WANG Bing,ZHOU Shi-fu,CAI Feng-lin,MA Zhao-sheng Dept.of General Surgery,Forth Renmin Hospital of Wuxi City,Wuxi 214062,China;Expression of PTEN,P-AKT,P-ERK protein in gastric carcinoma tissues and their clinical significance[J];Journal of Modern Oncology;2008-09
7 LUO Wen-juan 1,GUO Yuan-wen 2,Xu xue-mei 1,LI Xiao-ying 1,HE Lang-chong 1 1Medicine School of Xi'an Jiaotong University,Xi'an 710061,China;2Xi'an Children's Hospital,Xi'an 710003,China;Epidermal growth factor receptor and related anti-EGFR medicine[J];Journal of Modern Oncology;2010-03
8 Qinglei GAO1, Fei YE2, Xi XIA 1, Hui XING1, Yunping LU1, Jianfeng ZHOU1, Ding MA1# 1Department of Obstetrics and Gynecology, 2Department of Neurosurgery, Tongji Hospitol, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;Correlation between PTEN Expression and PI3K/Akt Signal Pathway in Endometrial Carcinoma[J];华中科技大学学报(医学英德文版);2009-01
9 Nicholas TRAKUL, Marsha R. ROSNER* Ben May Institute for Cancer Research, University of Chicago, 5841 S. Maryland Avenue., Chicago, IL 60637, USA;Modulation of the MAP kinase signaling cascade by Raf kinase inhibitory protein[J];细胞研究(英文版);2005-01
10 YAO Li-hua1,HU Rong-fei2,ZHONG Li-li3 1 Department of Ultrasound,Baoshan Branch of Shanghai First People's Hospital,Shanghai Jiaotong University2 Department of Ultrasound,Baoshan Branch of Huashan Hospital,Fudan University3 Department of Gynecology and Obstetrics,Baoshan Branch of Shanghai First People's Hospital,Shanghai Jiaotong University;Transvaginal Sonography and Hysteroscopy in Diagnosing Uterus Endometrial Lesions[J];Chinese Computed Medical Imaging;2008-02
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