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《Chinese Journal of Gerontology》 2015-05
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Expression and significance of Decorin in two human endometrial carcinoma cells cultured in vitro

DENG Shou-Heng;LI Lin-Jun;CAO Feng-Jun;Center of Oncology,People's Hospital Affiliated to Hubei University of Medicine;  
Objective To investigate the effects of RG alone or combined with RA on cell proliferation and Decorin expression in cultured two human endometrial carcinoma cells Ishikawa( PTEN-) and HEC-1A( PTEN +) in vitro.Methods After treated with RG alone or combined with RA for 24 hours,PCNA was measured to determine the proliferative inhibition effects of two inhibitors on tumor cells.The expression of Decorin m RNA and Decorin protein was measured by RT-PCR and Western blot respectively.Results In Ishikawa cells,RG alone or combined with RA could decrease cell PCNA positive rate and promote the expression of Decorin m RNA and protein abundance.The effect of RG combined with RA was better than that of RG alone.But in HEC-1A cells,the effects above were not obvious.Conclusions Loss of PTEN in endometrial carcinoma cells may inhibit the cell proliferation and promote the expression of Decorin m RNA and protein abundance,which due to the enhancing sensitivity of cells to related signal transduction inhibitors.
【Fund】: 湖北省教育厅项目(Q20092401);; 湖北医药学院创新团队项目(2008CXZ02);; 湖北省自然科学基金(2013CDZ011)
【CateGory Index】: R737.33
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