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Mechanism of lipid peroxidation in Dgalactoseinduced brain aging model

Cui Xu,Li Wenbin,Zhang Binglie et al Institute of Geriatrics,General Hospital of PLA,Beijing 100853  
おおhe effects of lipid peroxidation and protein metabolism induced by Dgalactose were investigated in vivo and in vitro.The levels of MDA,lipofuscin,SOD and GSHPx in rat ,house,cultured neruons and human fetal lung fibroblasts were studied respectively.The results showed that the levels MDA and lipofuscin were markedly increased,but SOD and GSHPx decreased,with that the total RNA and dissoluble protein reduced while undissoluble protein was increasde.These reasults were similar to those aged control and HypoxanthineXanthine reaction system(O-2),indicating that reactive oxyger species (ROS) especially (O-2).were generated in the course of Dgalatose metabolism,lipid peroxidation induced by ROS might be the cause of this brain aging model.
【CateGory Index】: R-332,
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