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《Chinese Journal of Clinicians(Electronic Edition)》 2011-12
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Effect of quercetin on matrix metalloproteinases and Cathepsin-D of the SW480 human colon cancer cell in vitro

MENG Yong,LI Hua,LIN Zeng-hai,WU Hua-tao,MA Tao.Department of General Surgery,The First Affiliated Hospital of Shantou University Medical College,Shantou 515041,China  
Objective To observe the secretion of matrix metalloproteinases in human colon carcinoma cell line SW480 treated by quercetin and to detect the expression of Cathepsin-D in SW480 cell treated by quercetin.Methods Zymogram analysis assay was used to analyze the effect on the secretion of matrix metalloproteinases in human colon carcinoma cell line SW480.The expression of Cathepsin-D in SW480 cell treated by quercetin was measured by immunohistochemistry method.Results Zymogram analysis assay showed the secretion of matrix metalloproteinases in human colon carcinoma cell line SW480 treated by quercetin decreased.With increasing concentration of quercetin,the secretion of MMP-2 and MMP-9 decreased.Immunohistochemistry method demonstrated the positive expression of Cathepsin-D in SW480 cell was suppressed by quercetin in a time-and dose-dependent manner.Conclusions Quercetin can suppress the secretion of matrix metalloproteinases and the expression of Cathepsin-D in human colon carcinoma cell line SW480.These are probably the reason that quercetin inhibits invasion and metastasis of colon cancer cells.
【Fund】: 2009年广东省中医药局科研课题(2009232);; 2009年广东省科技攻关项目(2009B030801321)
【CateGory Index】: R735.35
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