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《Chinese Journal of Clinicians(Electronic Edition)》 2011-16
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Expression and correlation of MLVD and HIF-1α in differentiated thyroid carcinoma

LV Bao-jun,HOU Bing-zong,GOU Xin-min,WANG Xiao-hong.Department of Thyroid and Breast Surgery,The Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai 519000,China  
Objective To investigate the expression and correlation of MLVD and HIF-1α in differentiated thyroid carcinoma.Methods MLVD and HIF-1α in 100 specimens of differentiated thyroid carcinoma were detected by immunohistochemistry.The correlation of HIF-1α expression to MLVD was analyzed by Spearman's rank correlation.Results MLVD and HIF-1α were dramatically higher in the differentiated thyroid carcinoma than that in the nodular goiter tissues(t=4.153 and χ2=21.061,P0.05).The positive correlation was observed between MLVD and HIF-1α in the differentiated thyroid carcinoma(r=0.662,P0.05).Conclusions MLVD and HIF-1α expression of differentiated thyroid carcinoma increase dramatically.HIF-1α is positively correlated with MLVD in the differentiated thyroid carcinoma.
【Fund】: 珠海市卫生局医学科研基金(2010060)
【CateGory Index】: R736.1
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