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《Chinese Journal of Clinicians(Electronic Edition)》 2012-16
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The clinical and coronary features of patients with premature coronary artery disease

ZHANG Xiao-feng,CHEN Zhong,WEN Jian,TENG Chang-qing.Department of Cardiology,The Affiliated Nanjing Second Hospital of Southeast University,Nanjing 210009,China  
Objective To evaluate the risk factor of clinical and coronary artery lesions in patients with premature coronary artery disease(PCAD).Methods The baseline clinical and coronary angiographic data of 692 patients undergoing coronary angiography(CAG)were collected and analyzed.All patients were divided into PCAD group(n=284,female65 years,male55 years),Later-onset CAD(aged coronary artery disease)group(n=182,female≥65 years,male≥55 years)and non-CAD group(n=226,female65 years,male55 years).Results (1)Compared with non-CAD group,patients in PCAD group had significantly more traditional cardiovascular risk factors(2.01±1.22 vs.1.01±0.93,P0.05),significantly higher ratio of male patients,hypertension,type 2 diabetic mellitus,smoking,drinking,obesity and family history of PCAD(all P0.05).(2)Compared with Later-onset CAD group,patients in PCAD group had significantly fewer traditional cardiovascular risk factors(2.01±1.21 vs.2.89±1.41,P0.05),while had significantly higher ratio of family history of PCAD [60/284(21.1%)vs.22/226(12.1%),P0.05],higher LVEF values(0.63±0.1 vs.0.61±0.12,P0.05)and significantly higher ratio of single vessel lesion [129/284(45.4%)vs.36/226(19.8%),P0.001].Both groups had significantly higher ratio of vessel lesions in LAD[238/284(83.8%)vs.165/226(90.7%),P0.05].(3)The logistic regression analysis showed that family history of PCAD,smoking,hypertension,type 2 diabetic mellitus and obesity were independent risk factors for the development of PCAD[95% CI:hypertension 1.604-3.788(P0.001),obesity 1.303-3.376(P=0.002),type 2 diabetic mellitus 2.040-7.771(P0.001),smoking 1.783-5.488(P0.001),family history of PCAD 6.063-107.431(P0.001)].Conclusions Patients with PCAD had higher ratio of family history of PCAD.
【CateGory Index】: R541.4
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