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Inhibition of Lens Damages lnduced by UV lrradiation by Se-Containing Garlic Polysaccharide

Yang Ming; Wang Mingyi; Hu Qiyue (National Research Laboratories of Natural and Biomimetic Drugs, Beijing Medical University)  
UV-irradiation is among the important factors that can induce cataract in human eyes. After lens proteins were exposed to UV--irradiation by a high voltage Hg lamp at 200-400 nm of wave-length the tryptophan fluorescence decreased, while the light-sensitive material, N-formyl-kynurenine (NFK) increased. In the process,the proteins kept on crossullnking and polymerizing,and the ratio of high molecular weight protein (HMWP) increased. As a result,the lens became cloudy and cataract was formed. \ Se-containing garic polysaccharide (Se-GPS) was isolated and purified by means of Sephadex chromatography. Experiments indicate that Se-GPS possesses protective effects on lens protein against oxidative damage induced by UV-irradiation and is one hundred times as potent as Vitamin C, which paves the way for the preparation and development of the drugs to treat UV-irradiation-induced cataract.
【CateGory Index】: O799
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