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《Chinese Journal of Coal Industry Medicine》 2004-02
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Xiao Li,Cai Dingbang,Zhuang Siqi,et al.Department of Pediatrics,The First people's Hospital of Zhaoqing,Guangdong 526021  
Objective To observe the dynamic changes of cellular immunologic function (T-cell subpopulation) and β-endorphin(β-EP) level of asphyxia newborns,and to explore β-EP's regulation mechanism of cellular immune. Methods All cases were divided into two groups: asphyxia group (45 cases) and normal group(20 cases). Two blood samples were collected at the first day and the seventh day after birth,β-EP, were detected. Results Compared with normal group,cellular immunologic function of asphyxia group were inhibited obviously and the degree was positive to asphyxial degree.Level of β-EP increased significantly,(201.45±82.97)pg/ml in normal group,(335.22±75.82)pg/ml in mild asphyxia group,(882.45±112.37)pg/ml in severe asphyxia group(P0.01).There were significant difference in level of β-EP,CD3,CD4,CD8 among groups(P0.05).To asphyxia group,there were significant correlation between level of β-EP and immunologic indexes except CD8,correlation coefficient (r)was 0.457~0.728. Conclusion Cellular immunologic function of asphyxia newborns are inhibited obviously and inhibited degree is positive to asphyxial degree,β-EP play a role in inhibited regulation of the cellular immunologic function.
【CateGory Index】: R722.12
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