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《Chinese Journal of Coal Industry Medicine》 2011-08
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THE PROTECTIVE EFFECTS OF SEVOFLURANE ON LUNG ISCHEMIA REPERFUSION INJURY IN RATS

Zhang Shubo,Li Baoyong,Gao Xiaozeng,et al.Department of anaesthesia,hebei united university afiliated hospital,Tangshan 063000,China  
Objective To study the protective effects and mechanisms of sevoflurane on lung ischemia reperfusion injury in rats.Methods 30 healthy SD rats were randomly divided into three groups(n=10).Sham group(Sham group): the left Pulmonary hilum was dissociated after thoraeotomy without occlusion and mechanically ventilated to the end;Ischemia reperfusion group(I/R group):the left pulmonary hilum was occluded for 45 min and reperfused;Sevoflurane-Ischemia reperfusion group(I/R+S group):administing IMAC Sevoflurane lasted for the experiment,others similar to I/R group.All rats in each group at reperfused 180 min get lung tissue and bronchoalveolar lavage fluid(BALF) samples.The contents of ICAM-1 and NF-кB in lung tissue were determined by immunohistochemical staining,and the OD value of ICAM-1 and NF-кB labelled tissue was then determined within each field of analysis.Using light microscope investigated pathological changes of lung.The parameters included dry/wet(D/W)yeloperoxidase(MPO)uperoxide dismutase(SOD).Results With the increasing of reperfusion stage,all test groups showed apparent lung injury changes,the expression of lung tissue ICAM-1 and NF-кB were increasing apparently,the optical density of NF-κB and ICAM-1 in I/R group were much higher than that in I/R+S group.In I/R group significant membrane damages of lung alveolar epithelial cell was more heavily than I/R+S group(P0.05).While pathological changes were slight in I/R+S group,the expression of MPO and BALF were increasing apparently,the tissue of lung D/W and SOD were lower apparently(P0.05).Conclusion Sevoflurane show protective effects for the LIRI in rats,the possible protective mechanisms include down-regulating expression of ICAM-1 and NF-кB.
【Fund】: 河北省唐山市科学技术局项目(10150204A-39)
【CateGory Index】: R965
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