Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Immunology》 2008-03
Add to Favorite Get Latest Update

The effect of ozone therapy on the shift of Th1/Th2 subsets in patients with lymphoma

LI Li,ZHANG Qiao-Hua,HOU Shu-Ling,HE Jian-Xia,QIAO Li-Juan.Department of Hematology,the 2nd Clinical Medical College,Shanxi Medical University,Taiyuan 030001,China  
Objective:To observe the effect of ozone therapy on the shift of CD4+T lymphocytes Th1/Th2 in peripheral blood of patients with non-Hodgkin lymphoma before and after chemotherapy.Methods:Treating group of 37 patients with non-Hodgkin lymphoma was given ozone therapy during the chemotherapy,combined with major O3 auto-hemoytherapy and rectal O3 gas insuffiation.Contrasting group of 30 patients with the same illness was given the same chemotherapy.Each was given two cycles.IFN-r and IL-4′s expression in CD4+T lymphocytes were detected by FCM in 67 cases of patients with NHL and 30 healthy adults to reflect Th1,Th2 cell′s quantities and to evaluate the curative effect and the changes of tumor-makers LDH and β2-MG.Results:①Compared with those of the normal controls,peripheral Th1 cells and Th1/Th2 ratio were markedly lower in patients with NHL.There was significant difference between them,whereas Th2 cell had no obviously changes.②After treatment,Th1 cells and Th1/Th2 ratio apparently increased(P0.05) in treating group,but Th2 cells had no significant changes with lowered LDH and β2-MG.③In contrasting group:Th1 cell,Th1/Th2 ratio and LDH were markedly reducd,but Th2 cell increase and β2-MG had no significant changes after treatment.④After treatment,treated group′s Th1 cell and Th1/Th2 ratio were higher than in contrast group,while Th2 cell,LDH and β2-MG of treating group were lower than those of in contrast group.The difference had marked significance.⑤The treated group′s complete response (CR) was 64.9%.Partial response (PR) was 29.7% and CR+PR was 94.6%.The contracting group′s CR was 40.0% and CR+PR was 70.0%.Compared with the two groups,treated group′s CR and CR+PR were significantly increased with statistical significance (P0.05).Conclusion:It is suggested that Th1 cells decrease and Th2 cells are nearly normal,so Th1/Th2 balance of patients with NHL shift to Th2 bias.After the chemotherapy,the ratio of Th1/Th2 to Th2 subsets is changed,but O3 can interfere or depress the balance of Th1/Th2 shift to Th2.Using ozone as an adjunct to chemotherapy can improve the recent curative effect in NHL.
【Fund】: 山西省卫生厅科技攻关项目基金资助(No200501)项目
【CateGory Index】: R733.1
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 1 Hits
1 Guan Jingyue1,2,Wang Beibei2 ( 1Dept of Interventional Radiology,Nanfang Hospital,Southern Medical University,Guangzhou 510515;2 Dept of Gynaecology and Obsetetrics,The Second Hospital of Anhui Medical University,Hefei 230601);Therapeutic effect of medical ozone on VX2 tumor in rabbits[J];Acta Universitatis Medicinalis Anhui;2010-06
【Citations】
Chinese Journal Full-text Database 5 Hits
1 JIANG Wen-Qi Skate Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P. R. China;Advancement of Biotherapy for Malignant Lymphoma[J];Chinese Journal of Cancer;2005-08
2 PENG Jian-liu~1,WU Ping~2(1.Dept.of Biology,Guangdong Education Institute,Guangzhou,Guangdong, 510303,P.R.China;2.The Central Laboratory,Affiliated Hospital of Guangdong Medical College,Zhanjiang,Guangdong,524001,P.R.China);Clinical Significance of Th1/Th2 Cytokines in the Peripheral Blood Lymphocytes of Patients with Cardia Cancer[J];Journal of Guangdong Education Institute;2006-03
3 Gong Jie,Zhang Yan,Dong Yan.The Third Hospital of Chengdu,Chengdu,Sichuan 610000,China;A Clinical Controlled Study of Immune Ozone Therapy in 105 Viral infection Patients.[J];Sichuan Medical Journal;2006-03
4 XUE Wei-guo,XU Yong-sheng,SUN Jie,et al. (Department of Otolaryngology,Qingdao Municipal Hospital,Qingdao 266011,China);Flow cytometry of Th1 and Th2 cells in peripheral blood of recurrent nasal polyps patients[J];Chinese Journal of Otorhinolaryngology-Skull Base Surgery;2006-03
5 SHEN Hong-yan, SUN Zhi-jun. Department of General Surgery, The First Affiliated Hospital, Chongqing University of Medical Science, Chongqing 400016, China;Th1/Th2 Cell and Tumor Recurrence[J];Chinese Journal of Bases and Clinics in General Surgery;2006-04
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 CHEN Jun1 XUAN Yonghua2 LIU Guangyan2 WEI Lixia21 Department of Otorhinolaryngology,Affiliated Hospital of Binzhou Medical University,Binzhou 256603;2 Department of Health and Care,Binzhou Vocational College;The expression and significance of ki-and Fas-L in the epithelial cells of nasal polyps[J];Journal of Binzhou Medical University;2010-04
2 LI Li1,LEI Lin-sheng1,YU Chuan-lin1,ZHU Zheng-guang1,ZHANG Qun1,LI Jian-jun2,CHEN Na-na1,WU Shu-guang1 1Institute of Pharmaceutical Sciences,School of Pharmaceutical Sciences,2School of Basic Medical Science,Southern Medical University,Guangzhou 510515,China;Changes of serum interferon-γ levels in mice bearing S-180 tumor and the interventional effect of immunomodulators[J];Journal of Southern Medical University;2008-01
3 Qi Meifeng,Zhou Wei(The Second People's Hospital of Changzhou Prefecture of Jiangsu Province,Changzhou 213003);Study for the effect on immune response and comfort degree by timing postoperative injection of DC vaccines for patients with breast cancer[J];Journal of Nurses Training;2011-22
4 QI Mei-fen,ZHU Yulan(Department of Breast Surgery,the Second People's Hospital of Changzhou,Nanjing Medical University,Changzhou 213003,China);Influence of Different Intradermal Puncture on Dendritic Cell Vaccine Induced Immune Reaction in Breast Cancer Patients[J];Journal of Nursing Science;2009-10
5 Wang Jinyue,Gao Jianlei,Zhang Zhijian,Liu Yongfeng (Institute of Physical Education,Foshan College of Science and Technology,Foshan,528000,Guangdong,China);Research on the Development of Exercise and Immunity and It`s Methodology[J];Journal of Jilin Institute of Physical Education;2009-02
6 YUE Yan-hong1,SUN Zhi-jun2.1.Department of General Surgery,Traditional Hospital of Meishan,Meishan,Sichuan 620010,P.R.China;2.Department of General Surgery,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,P.R.China;The Expression and Significance of Helper T Lymphocyte 1 and 2 Type Cytokines before and after Breast Cancer Surgery[J];West China Medical Journal;2011-07
7 Liu Fang1,Liu Liping2(1.Department of Biochemistry,QingHai University medical college;2.Department of Tumor,people′s hospital of QingHai);DETECTION OF SERUM IFN-γ,IL-4 AND IL-6 CYTOKINES IN PATIENTS WITH GASTRIC CANCER AND ITS CLINICAL SIGNIFICANCE[J];Journal of Qinghai Medical College;2008-02
8 WAN Hai-yan,JIANG Yu-jie,WANG Xin (Department of Hematology,Shandong Provincial Hospital Affiliated to Shandong University,Jinan 250021,China);Correlation of Cathepsin D expression to chemosensitivity of human lymphoma cell lines Raji to Adriamycin[J];Journal of Shandong University(Health Sciences);2009-07
9 LIU Wen-long,XIA Li-jun (Department of Otolaryngology,First Hospital of Shanxi Medical University,Taiyuan 030001,China);IL-12 and IL-4 expressions in nasal polyps[J];Journal of Otolaryngology and Ophthalmology of Shandong University;2009-02
10 PENG Li-qiong,GENG Yan,LIANG Zhong-hui(303 Hospital of People's Liberation Army of China,Nanning 530021,P.R.China);Combination of ozone therapy and effective microorganismnal in the treatment of diarrhea irritable bowel syndrome[J];Shandong Medical Journal;2011-04
【Co-references】
Chinese Journal Full-text Database 8 Hits
1 LI Yong,KONG Ling-qing,GAO Hong,YAN Yu-lin(College of Animal Science,Yunnan Agriculture University,Kunming,Yunnan,650201,China);Progress on Free Radical and Diseases[J];Progress in Veterinary Medicine;2008-04
2 HE Xiao-feng, LI Yan-hao~* (Department of Interventional Radiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China);Ozonetherapy: the past, present and future[J];Chinese Journal of Interventional Imaging and Therapy;2005-05
3 YOU Wei-wen, DU Xin, ZHANG Qiong-li, et al. (1. Department of Hematology, Shenzhen Municipal Second People's Hospital, Shenzhen 518035, Guangdong, P. R, China);Expression of IFN-γ and IL-4 in T helper cells and T cytotoxic cells in leukemia patients[J];China Tropical Medicine;2007-06
4 HE Guang-sheng1, SHAO Zong-hong2, WU De-pei1, WANG Xiu-li1, MIAO Miao1, LIU Hong2, SHI Jun2, BAI Jie2, SUN Juan2, JIA Hai-rong2, QIAN Lin-sheng2, YANG Chong-li2(1. Department of Hematology, First Affiliated Hospital, Soochow University, Jiangsu Institute of Hematology, Suzhou 215006, China; 2. Institute of Hematology and Blood Disease Hospital of CAMS & PUMC, Tianjin 300020, China);Changes of Th Cell Subsets in Bone Marrow of Patients with Severe Aplastic Anemia and Myelodysplastic Syndrome[J];;2004-05
5 Zeng Qiaohui,Mei Zhiyong,Zhong Fengyi,et al.(Department) of Pediatrics,The 2~(nd) Affiliated Hospital of Sun Yat-sen University,Guangzhou 510120,China;Profile and significance of serum IL-12,IL-4 and IFN-γ in children with Henoch-Schonlein purpura[J];China Child Blood;2005-06
6 Bai Songting, Yuan Zhixi, Zhao Xiaoming, Zou Xiang, Sheng Guangyao. Department of Pediatrics, the First Affiliated Hospital of Medical College, Zhengzhou University, Zhengzhou 450052, China;Levels of TPO, TSP-1 and TGF-β_1 in bone marrow in children with idiopathic thrombocytopenic purpura[J];Journal of China Pediatric Blood and Cancer;2006-04
7 LI Qiu, YANG Xiqiang, LI Yongbai, et al. Children′s Hospital, Chongqing University of Medical Sciences,Chongqing 400014,China;Functional status of T cells in children with Henoch-Schonlein purpura[J];Chinexe Journal of Pediatrics;2001-03
8 Ge Zi-liangDoctor, Associate Professor, Department of Physics, Tongji University. Shanghai 200092;Effect of Kill Bacteriums by Ozone and Its Aoolication[J];Nature Magazine;1999-01
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 XIA Zhong- jun1* , HUANG Ren- wei1, WU Xiang- yuan1, LIN Gui- zhen1, ZHANG Li2, GUAN Zhong- zhen2. 1.Department of Hematology, the Third Affiliated Hospital, Sun Yat- sen University of Medical Sciences, Guangzhou 510630, P.R.China 2.Department of M;Prognostic Value of Serumβ_2- Microglobulin Level in Patients with Non- Hodgkin′ s Lymphoma[J];Chinese Journal of Cancer;2001-04
2 WANG Changyin 1,ZOU Xiong 2,CHE Zhixiang 1, et al. (The Laboratory Department of Shandong Provincial Hospital,Jinan 250021,China;The Laboratory Department of Shandong University Qilu Hospital,250012,China);The correlation of T_H1/T_H2 shift and gastric cancer[J];Journal of Clinical Laboratory Science;2003-04
3 QIU Fa-bo,JIANG Xi-hong,WU Li-qun,LU Yun,FENG Jin-bo,ZHANG Jian Department of General Surgery,Qilu Hospital of Shandong University (Jinan 250012,China);The expression of Th1/Th2 type cytokines in primary hepa-tic cancer tissue and its adjacent liver tissue[J];Chinese Journal of Current Advances in General Surgery;2003-02
4 ZHANG Ning * , XU Yong-jian, ZHANG Zhen-xian g, DENG Qun-yi, XIONG Wei-ning, LIU Xian-sheng Department of Respiratory Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan 430030, China;Role of nitric oxideNF——κB signaling pathway in differentiation of hu man nave Tlymphocytes into Th1/Th2 cells[J];Journal of Cellular and Molecular Immunology;2004-02
5 NIU Jia-feng, ZHANG Cai *, ZHANG Jian-hua, XU Xiao-qun, ZHANG Wei-dong, WANG Jun-fu, GAO Chun-yi Institute of Basic Medicine, Shandong Academy of Medical Sciences, Key Laboratory for Tumor Immunity and Genetic Engineering of Shandong Province, Key Laboratory for Modern Medicine and Technology of Shandong Province, Jinan 250062, China;Up-regulation of IFN-α on expression of MICA in the cervical carcinoma cell lines[J];Chinese Journal of Cellular and Molecular Immunology;2006-05
6 LIU Jin-bao, ZHONG Nan-shan, LI Shu-nong (Department of Pathophysiology, Guangzhou Medical College,Guangzhou 510182, China);Specific surface markers of Th1/Th2 subsets and their identification[J];Chinese Journal of Pathophysiology;2000-08
7 CHEN Rong 1, SHI Jian-bo 2, XU Geng 2, DI Jing-fang 3, ZENG Shan 3, ZENG Yao-ying 3 (? 1?Department of Otorhinolaryngology, Zhongshan City People's Hospital, Zhongshan 528403, China; ? 2?Department of Otorhinolaryngology, Third Hospital of Sen-Yat-sen University of Medical Sciences,Guangzhou 510630, China;? 3?Institute of Tissue Transplantation and Immunology of Jinan University, Guangzhou 510632, China);The expression of IFN-γ and IL-4 on T lymphocytes that infiltrate in nasal polyps[J];Chinese Journal of Pathophysiology;2003-12
8 ZHANG Zhi gang, ZHENG Yi qing (Department of Otolaryngology, The Second Affiliated Hospital of Sun Yat Sen University, Guangzhou 510120, China);A study of relationship between eonsinphils and recurrence after the nasal polyps surgery[J];Chinese Journal of Otorhinolaryngology-skull Base Surgery;2004-05
9 Zhang Cai Tian Zhigang Wei Haiming et al Shandong Cancer Biotherapy Center, Shandong Academy of Medical Science, Jinan;The Expression of Non-Classical HLA Class Ⅰ Molecules (HLA-G and HLA-E) in Human Tumor Cell Lines and the Regulatory Effect of IFN-γ[J];Chinese Journal of Clinical Oncology;2001-04
10 CAO Zhixin,CHEN Xiaoping,WU Zaide.Hepatic Surgery Center,Ton gji Hospital,Tongji Medical College,Huazhong University of Science and Technol ogy,Wuhan 430030,China;A study on the spleen Th1/Th2 cytokines immunological condition in the patients with primary hepatocellular carcinoma combined with liver cirrhosis[J];Chinese Journal of Experimental Surgery;2001-06
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved