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《Chinese Journal of Immunology》 2016-09
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Value of PGⅠ,PGⅡ,G-17 and Hp IgG in screening of chronic atrophic gastritis and gastric cancer

WEI Hua;ZHANG Lei-Lei;LI Yan;SUO Zhi-Min;Department of Endoscopy,Huaihe Hospital,Henan University;  
Objective:To analyze the value of pepsinⅠ(PGⅠ),pepsinⅡ(PGⅡ),gastrin-17(G-17) diagnostic and Helicobacter pylori(Hp Ig G) antibody in screening chronic atrophic gastritis and gastric cancer.Methods:90 patients with an upset stomach in our hospital from May 2014 to May 2015 were selected for the study,according to the pathological diagnosis which were divided into normal control group(including chronic non-atrophic gastritis),chronic atrophic gastritis group and gastric cancer,30 cases in each group.The level of PGⅠ,PGⅡ,G-17 and Hp Ig G antibody positive rate in the three groups of patients were compared.Results:The level of PGⅠ,PGⅡ in gastric cancer patients were lower than the control group and chronic atrophic gastritis group.And the index of chronic atrophic gastritis patients were lower than control group.The level of G-17 in gastric cancer group was higher than chronic atrophic gastritis group and the control group,and chronic atrophic gastritis group and the control group had no significant difference.The Hp Ig G antibody positive rate in gastric cancer group was significantly higher than other two grups.The level of PGⅠ and PGⅡ in Hpinfected patients were lower than uninfected Hp patients,and the level of G-17 was higher than uninfected Hp patients.The level of PGⅠ,PGⅡ were significantly negatively correlated with age,pathological stage and metastasis,and positive related with the degree of differentiation;but the level of G-17 and Hp Ig G antibody rate were positive related with age,pathological stage and metastasis,and negatively correlated with the degree of differentiation.Conclusion:PGⅠ,PGⅡ and Hp Ig G antibody screening have a good diagnostic value in chronic atrophic gastritis and gastric cancer,and better diagnostic value of gastric cancer,G-17 diagnostic value of gastric cancer is much better than the chronic atrophic gastritis;and the level of PGⅠ,PGⅡ,G-17 and Ig G antibody positive rate are closely related to the clinicopathological features of gastric cancer patients.
【CateGory Index】: R573.32;R735.2
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【Co-citations】
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1 WEI Hua;ZHANG Lei-Lei;LI Yan;SUO Zhi-Min;Department of Endoscopy,Huaihe Hospital,Henan University;;Value of PGⅠ,PGⅡ,G-17 and Hp IgG in screening of chronic atrophic gastritis and gastric cancer[J];中国免疫学杂志;2016-09
2 Qian Taibao;Yu Lan;Zhang Changchun;Zhou Jiansheng;Department of Orthopedics,the First Affiliated Hospital of Bengbu Medical College;Department of Pathology,the First Affiliated Hospital of Bengbu Medical College;;Increase in immunohistochemical expression of CD133 and ALDH1 and angiogenesis in osteosarcoma[J];中国组织化学与细胞化学杂志;2016-02
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