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《Chinese Agricultural Science Bulletin》 2012-08
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The Protection Mechanism of Licorice Flavonoids on Acute Lung Injury in Mice

Zhang Jiaying,Wei Miaomiao,Chu Xiao,Deng Xuming,Zhang Qiaoling,Liu Bo(College of Animal Science and Veterinary Medicine,Jilin University,Changchun 130062)  
To study the preventive and therapeutic effects of licorice flavonoids on nonspecific lung injury in mice.We established the mouse model of acute lung injury by nasal instillation of lipopolysaccharide(LPS).Mice were treated with licorice flavonoids at dosages of 30 mg/kg before or after LPS nasal instillation.At 6,12,24 h after LPS nasal instillation,cytokine level detection,pathological examination,the lung wet/dry weight ratio and the activity changes of NF-κB were performed.The results showed that licorice flavonoids displayed significantly anti-inflammatory in the lung tissue by reduce W/D ratios,attenuated inflammatory cell infiltration and suppress TNF-α,IL-6 and IL-1β expression levels.In addition,the treatment effect of licorice flavonoids was better than prophylaxis effect.Licorice flavonoids could also inhibited the degradation of I κB and the transfer of NF κB to nuclear.Thus licorice flavonoids could inhibited common LPS downstream channel that was NF-κB.Therefore,We suggested that licorice flavonoids effectively attenuate LPS-induced pulmonary inflammation through inhibition of NF κB pathway,and treatment effect of licorice flavonoids was better than prophylaxis effect.
【Fund】: 国家自然科学基金资助项目“2型猪链球菌消化道感染机制及其诱导的自噬作用研究”(30972170);; 科学前沿与交叉学科创新项目“2型猪链球菌(SS2)经消化道粘膜感染的研究资助”(200903337)
【CateGory Index】: S858.91
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