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《Chinese Agricultural Science Bulletin》 2012-23
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Geniposide Protects against Lipopolysaccharide-induced Acute Lung Injury in Mice

Wang Lisha,Mei Mei(Department of Outpatient Clinic of Division of Agriculture,Jilin University,Changchun 130062)  
The purpose of this study was to evaluate the effect of geniposide on acute lung injury(ALI) induced by lipopolysaccharide(LPS) in mice.Male BALB/c mice were pretreated with dexamethasone(DEX) or geniposide 1 h before intranasal instillation of LPS.Seven hours after LPS challenge,the levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and interleukin-10(IL-10) in the bronchoalveolar lavage fluid(BALF) were measured.The number of total cells,neutrophils,and macrophages in the BALF were also determined.The extent of IκB phosphorylation was detected by Western-blot.Pretreatment with geniposide was found to decrease the W/D ratio of the lung tissue;attenuate lung histopathologic changes,alveolar hemorrhage,and neutrophil infiltration,with evidence of reduced myeloperoxidase(MPO) activity;down-regulate the level of pro-inflammatory mediators,including TNF-α and IL-6;up-regulate the concentration of IL-10;and inhibit the phosphorylation of IκB.Taken together,our results suggested that Geniposide might provide protective effects against LPS-induced ALI by mitigating the inflammatory response and that the compound's mechanism of action might involved blocking the nuclear factor-kappaB(NF-κB) signaling pathway activation.
【Fund】: 国家自然科学基金资助项目“穿心莲内酯抗菌作用靶机制的基因组学”(31072168)
【CateGory Index】: R285.5
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【References】
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【Citations】
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1 Zhang Jiaying,Wei Miaomiao,Chu Xiao,Deng Xuming,Zhang Qiaoling,Liu Bo(College of Animal Science and Veterinary Medicine,Jilin University,Changchun 130062);The Protection Mechanism of Licorice Flavonoids on Acute Lung Injury in Mice[J];Chinese Agricultural Science Bulletin;2012-08
【Co-citations】
Chinese Journal Full-text Database 1 Hits
1 ZHAO Xi-lan1,LIU Qiu-he2(1.Luohe Medical College,Luohe 462002,China; 2.Second Affiliated Hospital of Luohe Medical College,Luohe 462300,China);Effect of Total Flavones of Bidens bipinnata on Lipopolysaccharide-induced Acute Lung Injury in Rats[J];Chinese Journal of Experimental Traditional Medical Formulae;2012-24
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