Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Agricultural Science Bulletin》 2012-23
Add to Favorite Get Latest Update

Geniposide Protects against Lipopolysaccharide-induced Acute Lung Injury in Mice

Wang Lisha,Mei Mei(Department of Outpatient Clinic of Division of Agriculture,Jilin University,Changchun 130062)  
The purpose of this study was to evaluate the effect of geniposide on acute lung injury(ALI) induced by lipopolysaccharide(LPS) in mice.Male BALB/c mice were pretreated with dexamethasone(DEX) or geniposide 1 h before intranasal instillation of LPS.Seven hours after LPS challenge,the levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and interleukin-10(IL-10) in the bronchoalveolar lavage fluid(BALF) were measured.The number of total cells,neutrophils,and macrophages in the BALF were also determined.The extent of IκB phosphorylation was detected by Western-blot.Pretreatment with geniposide was found to decrease the W/D ratio of the lung tissue;attenuate lung histopathologic changes,alveolar hemorrhage,and neutrophil infiltration,with evidence of reduced myeloperoxidase(MPO) activity;down-regulate the level of pro-inflammatory mediators,including TNF-α and IL-6;up-regulate the concentration of IL-10;and inhibit the phosphorylation of IκB.Taken together,our results suggested that Geniposide might provide protective effects against LPS-induced ALI by mitigating the inflammatory response and that the compound's mechanism of action might involved blocking the nuclear factor-kappaB(NF-κB) signaling pathway activation.
【Fund】: 国家自然科学基金资助项目“穿心莲内酯抗菌作用靶机制的基因组学”(31072168)
【CateGory Index】: R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 2 Hits
1 QI Ya-jing 1,GU Jun-qiang 1,WANG Li 1,*,QIAN Hai-feng 1,ZHANG Hui 1,QI Xi-guang 1,LI Zhu 2,CHEN Yue 3 (1.School of Food Science and Technology,Jiangnan University,State Key Laboratory of Food Science and Technology,Jiangnan University,Wuxi 214036,China ;2.Astra Zeneca Phamaceutical Co.,Ltd.,Wuxi 214028,China;3.Nutricia Pharmaceutica(lWuxi)Co.,Ltd.,Wuxi 214111,China);Research progress in functional ingredients in the fruit of Gardenia jasminoides Ellis[J];Science and Technology of Food Industry;2013-14
2 ZHANG Yu;DENG Yan-hong;Department of Outpatient Clinic of Division of Agriculture,Jilin University;College of Veterinary Medicine,Jilin University;;The protective effects and mechanisms of geniposide on bronchial asthma in mice[J];Chinese Journal of Veterinary Science;2013-09
Chinese Journal Full-text Database 1 Hits
1 Zhang Jiaying,Wei Miaomiao,Chu Xiao,Deng Xuming,Zhang Qiaoling,Liu Bo(College of Animal Science and Veterinary Medicine,Jilin University,Changchun 130062);The Protection Mechanism of Licorice Flavonoids on Acute Lung Injury in Mice[J];Chinese Agricultural Science Bulletin;2012-08
Chinese Journal Full-text Database 1 Hits
1 ZHAO Xi-lan1,LIU Qiu-he2(1.Luohe Medical College,Luohe 462002,China; 2.Second Affiliated Hospital of Luohe Medical College,Luohe 462300,China);Effect of Total Flavones of Bidens bipinnata on Lipopolysaccharide-induced Acute Lung Injury in Rats[J];Chinese Journal of Experimental Traditional Medical Formulae;2012-24
Chinese Journal Full-text Database 10 Hits
1 LI Yun-xian et al (Department of Basic Courses,Southwestern Forestry College,Kunming,Yunnan 650224);Determination on Trace Elements in Gardenia by Microwave Digestion-ICP-AES[J];Journal of Anhui Agricultural Sciences;2010-22
2 YE Nan1,CHEN Feng 1,WANG Xi-ping 2,LUO Wu-kui 1,DONG Sheng-xiong1,2(1.Department of Chemistry and Environmental Science,Ningde Normal University,Ningde 352100,China; 2.College of Chemistry and Chemical Engineering,Fuzhou University,Fuzhou 350108,China);Research progress on extraction of gardenia yellow pigment[J];Chemical Engineering & Equipment;2011-09
3 TANG Xin-zong,LIU Shen,ZHANG Xiao-xia,CHEN Jian,WEI Wan-xing(School of Chemistry and Chemical Engineering,Guangxi University,Nanning 530004,China);Separatton of geniposide from gardenia by reversed back extraction with polyethylene glycol[J];Journal of Guangxi University(Natural Science Edition);2012-03
4 LI Xiong1,2,CHEN Qian-wen1 (1.School of Materials Science and Engineering,Central South University of Forestry and Technology,Changsha 410004,PRC;2.Hunan Vocational College of Science and Technology,Changsha 410004,PRC);The Supercritical CO_2 Fluid Extraction of Gardenia Yellow Pigment[J];Hunan Agricultural Sciences;2010-01
5 CHENG Qi-lai,LI Hong-liang,ZHANG Dao-ying. School of Pharmacy,Gannan Medical University,Ganzhou,Jiangxi 341000,China;Study on anti-arrhythmia effect of crocetin[J];Medical Journal of Chinese People's Liberation Army;2010-04
6 WANG Yue,DU Shou-ying,WU Qing,XIAO Yao,RONG Kun,YUAN Hang,LI Hui-yun,LI Ying,ZHAO Jing-yi(School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing 100102);Smashing extraction method for extracting active principle from Zhizi (Fructus Gardeniae)[J];Journal of Beijing University of Traditional Chinese Medicine;2012-10
7 GUO Bin1,FAN Qin-hua1,WANG Li2,ZHANG Zhi-qiang1,LIU Xiao-juan3(1.Department of Ophthalmology,The 81st Hospital of PLA,Nanjing 210002,Jiangsu,China;2.Research Institute of Field Surgery,Daping Hospital,The 3rd Military Medical University,Chongqing 400042,China;3.Department of Ophthalmology,Laoshan Clinic,The 401st Hospital of PLA,Qingdao 266102,Shandong,China);Crocin prevents the apoptosis of retinal microvascular endothelial cells induced by advanced glycosylation end products[J];Journal of Medical Postgraduates;2012-11
8 FU Ke Wang Shu-yan Bao Yu-min XIA Yu(College of Chemistry and Chemical Engineering of Inner Mongolia University for the Nationlities,Tongliao,028043);Extraction and Content Determination of Flavonoids in Gardenia[J];Journal of Inner Mongolia University for Nationalities(Natural Sciences);2012-05
9 WAN Yin1,2,FU Gui-ming1,2,3,* ,ZHANG Dan2,LUO Yang-fan1,2,CHAI Jian-xin1,2, CHEN Jian-fang1,2,LI Hong-ge1,2,WANG Jian-tao1,2 ( 1.State Key Laboratory of Food Science and Technology,Nanchang University,Nanchang 330047,China; 2.Food Engineering Department of Life Science and Food Engineering College,Nanchang University, Nanchang 330047,China; 3.Sino-German Food Engineering Center,Nanchang University,Nanchang 330047,China);Extraction of sterol from Gardenia jasminoides seed by the ultrasound technology[J];Science and Technology of Food Industry;2011-03
10 BAO Ya-ni,DONG Jian-qing,YUAN Fang(College of Food Science and Nutritional Engineering,China Agricultural University,Beijing 100083,China);Effect of Supercritical Carbon Dioxide Extraction Conditions on Fatty Acid Composition and Antioxidant Activity of Gardenia Fruit Oil[J];Food Science;2011-10
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved