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《Central South Pharmacy》 2005-04
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Intestine absorption kinetics of huperzine A in rats

Bai Min 1,2 ,Ding Ping-tian 1* ,Xie Jun-xia2,Wei Wei2 (1. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016; 2. Shijiazhuang Pharm Group,Shijiazhuang 050041)  
OBJECTIVE To determine the absorption of huperzine A in various intestine segments in rats. METHODS The absorption kinetics were obtained by the in situ perfusion method in rats. The concentration of huperzine A in intestine perfusate was measured by HPLC, and the concentration of phenolsulfonphthalein in intestine perfusate was measured by UV. RESULTS Huperzine A was steadily absorbed with the absorption rate constants at duodenum, jejunum, ileum and colon of 0.001 0,0.000 9,0.001 1,and 0.000 9 h -1 , respectively. CONCLUSIONS The absorption of huperzine A complied with the passive transport mechanism and first order kinetics, suggesting that huperzine A could be designed as a 24 h-sustained-release dosage form.
【CateGory Index】: R285
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