Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Central South Pharmacy》 2005-04
Add to Favorite Get Latest Update

Intestine absorption kinetics of huperzine A in rats

Bai Min 1,2 ,Ding Ping-tian 1* ,Xie Jun-xia2,Wei Wei2 (1. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016; 2. Shijiazhuang Pharm Group,Shijiazhuang 050041)  
OBJECTIVE To determine the absorption of huperzine A in various intestine segments in rats. METHODS The absorption kinetics were obtained by the in situ perfusion method in rats. The concentration of huperzine A in intestine perfusate was measured by HPLC, and the concentration of phenolsulfonphthalein in intestine perfusate was measured by UV. RESULTS Huperzine A was steadily absorbed with the absorption rate constants at duodenum, jejunum, ileum and colon of 0.001 0,0.000 9,0.001 1,and 0.000 9 h -1 , respectively. CONCLUSIONS The absorption of huperzine A complied with the passive transport mechanism and first order kinetics, suggesting that huperzine A could be designed as a 24 h-sustained-release dosage form.
【CateGory Index】: R285
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 10 Hits
1 ZHU Liang;YIN Li'na;LIANG Zehua;ZHANG Yawen;HUANG Xiaying;Wu Binli;WANG Shenghao;Department of Pharmacy,Zhejiang Chinese Medicine University;Zhejiang Academy of Medical Sciences;;Study on Intestinal Absorption Parts of Huperize A by in situ Low- speed Single Pass Perfusion Model[J];中华中医药学刊;2015-11
2 XIN Liang~a,LIU Yun~a,ZHANG Meng-qi~a,JIA Jing-ying~a,LU Chuan~a,LI Shui-jun~a,WANG Wei~b,LIU Gang-yi~a,YU Chen~a (a.Central Laboratory,b.Department of cardiology,Shanghai Xuhui Central Hospital,SHANGHAI 200031, China);Research progress of concentration determination and pharmacokinetics of huperzine A[J];中国新药与临床杂志;2012-12
3 LEI Yun,GAN Yong,ZHANG Hai-yan (State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences, SHANGHAI 201203,China);Progress in pharmaceutical studies of huperzine A[J];中国新药与临床杂志;2012-12
4 XIE Jiang-chun1,2,LIU Zhi-dong1,2,WANG Xiao-yu3,LI Nan1,2,SONG Xi-wei1,2,WANG Tao1(1.Tianjin University of Traditional Chinese Medicine,Research Institute of Traditional Chinese Medicine,Tianjin 300193;2.Tianjin University of Traditional Chinese Medicine,Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique,Ministry of Education,Tianjin 300193;3.Tianjin University of Traditional Chinese Medicine,College of Chinese Materia Medica,Tianjin 300193);Intestinal absorption kinetics of mangiferin in rats in vivo[J];中南药学;2010-05
5 ZHU Rong-hui1,2,ZHAO Jun-ning 1,BI Yue-qi 1,WU Yi 1,2,YANG Xia 1,2 1 Sichuan Academy of Traditional Chinese Medicine Sciences,Chengdu 610041,China;2 Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China;Advances in studies on intestinal absorption kinetics of Chinese materia medica[J];药物评价研究;2010-01
6 WANG Yong1,ZHOU Yan-bin2,TIAN Juan2,Ran Li-ling2,ZUO Ying2,ZOU Jian-jun3,DING Jin-song2(1.Sanjiu Pharmaceutical Company Limited,Shenzhen Guangdong 518029;2.School of Pharmaceutical Sciences,Central South University,Changsha 410013;3.First Affiliated Nanjing Hospital of Nanjing Medical University,Nanjing 210006);Determination of huperzine A in human plasma by HPLC-MS-MS and its application to a relative bioavailability of huperzine A tablets in healthy volunteers[J];中南药学;2009-08
7 TANG Yu1,2,ZHOU Wei1,HE Fuyuan2,3,LIU Cha1,YANG Dajian1(1.State Key Laboratory of Chinese Medicine and Molecular Pharmacology,Shenzhen 518507,China;2.College of Pharmaceutics,Hunan University of Traditional Chinese Medicine,Changsha 410208,China;3.Clinical Pharmacology Institute of Central South University,Changsha 410007,China);Release mechanism of huperzine-A swelling sustained-release tablets[J];中国中药杂志;2009-14
8 SUI Xin,BI Kai-shun,FANG Li-na,FENG Jing,CHEN Xiao-hui (School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016);Simultaneous determination of L-carnosine and phenolsulfonphthalein in rat single pass intestinal perfusion solution by HPLC[J];中南药学;2009-06
9 TANG Yu1,2,HE Fu-yuan2,3,ZHOU Wei1,LIU Cha1,YANG Da-jian1*(1.Shengzhen State Key Laboratory of China Medicine and Molecular Pharmacology & Hongkong Polytechnic University Institute of Modern Medicine,Shenzhen 518507;2.College of Pharmaceutics,Hunan University of Traditional Chinese Medicine.Changsha 410208;3.Institute of Clinical Pharmacology,Central South University,Changsha 410007);Optimization of formulation of Huperzine-A matrix tablets by orthogonal design[J];中南药学;2009-03
10 TANG Yu1,2,LIU Cha2*,ZHOU Wei2,YANG Da-jian2,HE Fu-yuan1,3((1.College of Pharmaceutics,Hunan University of Traditional Chinese Medicine,Changsha 410208;2.State Key Laboratory of Chinese Medicine and Molecular Pharmacology &Hongkong Polytechnic University Institute of Modern Medicine,Shenzhen Guangdong 518507;3.Institute of Clinical Pharmacology,Central South University,Changsha 410007);In vitro dissolution factors influencing release of huperzine A matrix tablets[J];中南药学;2008-06
Chinese Journal Full-text Database 3 Hits
1 ZHANG Li 1, CHEN Da wei 1, LI Fang jiu 2, SONG Ai hua 3, KUI Gang bo 1 (1 Department of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China; 2 The First Hospital Attached to China Medical University, Shenyang 110001, Chin;Studies on the absorption kinetics of famotidine in rats' intestines[J];沈阳药科大学学报;2001-03
2 Li Chunde(Institute of Information,Academy of Military Medical Sciences,Beijing 100850);ADVANCE OF DRUGS FOR TREATMENT OF ALZHEIMER′S DISEASE[J];中国新药杂志;1996-03
3 Mao Fengfei Tu xide Zhu Jiabi Zhao Luhua and Hu Zhenze (Department of Pharmaceutics);ABSORPTION OF BAICALIE IN SMALL INTESTINE OF RAT[J];南京药学院学报;1984-01
Chinese Journal Full-text Database 10 Hits
1 YANG Si-tao;TANG Hui;YING Xue;LIU Yan-fang;WANG Huan;Key Laboratory of Xingjiang Phaytomedicine Resource,School of Pharmaceutical Science,Shihezi University;The People's Hospital of Dali Prefecture;;Nanosuspensions Study of Gossypol: Preparation,Characterization and in Situ Single Pass Perfusion Intestinal Absorption[J];中国药学杂志;2014-10
2 Zhang Xiaohua1,Chen Lixue2,Jia Yimin1△(1.Department of Pharmacy,Chongqing Institute of Tumor Research,Chongqing 400030,China;2.Laboratory Research Center,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China);A study of rat in situ intestinal absorption of propranolol hydrochloride through single pass perfusion method[J];重庆医学;2012-36
3 NING Kang-jian1,ZHANG Ting-ting2(1.College of Animal Science,Anhui Science and Technology University,Fengyang 233100,China; 2.College of Animal Science and Technology,Anhui Agricultural University,Hefei 230036,China);Study of Baicalin on Anti-Inflammatory Effect on Mice[J];安徽科技学院学报;2012-06
4 ZHENG Xue-jing1,3,ZHAO Qing-chun1,2,YAN Ming2,ZHENG Yong-chang3,CHENG Gang1(1.Shenyang Pharmaceutical University,Shenyang 110016,China;2.The General Hospital of Shenyang Military Region,Shenyang 110016,China;3.The First People's Hospital of Shenyang,Shenyang 110044,China);Study on intestinal absorption kinetics of lomefloxacin in rats[J];实用药物与临床;2011-01
5 WANG Wen-yu1,JIANG Tie-fu2,WANG Zhi-gang1(1.Liaoning Institute of Pharmaceutical Industry,Shenyang 110015,China;2.463 Hospital of PLA,Shenyang 110042,China);Absorption kinetics of disodium oleanolic acid phosphate in rat small intestine[J];实用药物与临床;2008-04
6 XIA Yu-feng1,DAI Yue1,2,MENG Qing-yu3,WANG Qiang1,QIU Ling-ling1(1.College of Traditional Chinese Medicine,China Pharmaceutical University,Nanjing 210038,China;2.Jiangsu Key Laboratory for Molecular and Medical Biotechnology,Nanjing 210046,China;3.Hunan Institute of Pharmaceutical Industry research,Changsha 410014,China);Studies on absorption kinetics of scopoletin in rat stomachs and intestines[J];中国中药杂志;2008-15
7 Zhu Xi,Li Jun,Jin Yong,et al(School of Pharmacy,Anhui Medical University,Hefei 230032);The intestinal absorption kinetics of A771726 in rats[J];安徽医科大学学报;2008-03
8 JIN Ling-yu, ZHANG Yu, MA Ni-nan,SUN Yan-hui, JIAO Cheng-mei, LI San-ming(School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China);Intestinal absorption mechanism of venlafaxine hydrochloride in rats[J];中国药剂学杂志(网络版);2008-03
9 CHEN Cun-xiang,LI San-ming,LI Hong-ju,SUN Yang-hui(Department of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China);Preparation of monolithic osmotic pump tablets of famotidine[J];中国新药杂志;2007-13
10 ZHOU Dong-ju ZHAO Hui-ying YANG Ying-lu(College of Life Science and Technology,Beijing University of Chemical Technology,Beijing 100029,China);The absorption of puerarin in rats' intestines[J];北京化工大学学报(自然科学版);2006-05
Chinese Journal Full-text Database 10 Hits
1 FENG Xia1,2,ZHANG Yawen2,LIANG Zehua1,YIN Li’na2,WANG Qiao2,WU Binli1,2,WANG Shenghao2*(1.Department of Pharmacy,Zhejiang University of Traditional Chinese Medicine,Hangzhou 310053,China;2.Zhejiang Academy of Medical Sciences,Hangzhou 310013,China);Study on the Intestinal Absorption Kinetics of Asiatic Acid in Rats[J];中国现代应用药学;2013-06
2 LI Ji,LI Ling-jun,LOU Hua-wei(Shandong University of Traditional Chinese Medicine,Ji'nan 250355,China);In vivo Intestinal Absorption Kinetics Study of Rhynchophylline and Isorhynchophylline of Tiangou Jiangya Capsules[J];中国实验方剂学杂志;2013-06
3 WU Tao1,ZHENG Juan2,ZHANG Cheng-liang1,LIU Dong1* 1.Department of Pharmacy,Tongji Hospital,Tongji Medical College,Huazhong Science and Technology University,Wuhan 430033,China;2.Department of Pharmacy,Hubei Zhongshan Hospital,Wuhan 430033,China;Advances in studies on intestinal absorption of Traditional Chinese Medicine[J];药品评价;2013-06
4 PENG Jun-jie,LIN Cong-cong,LI Jiang,ZHU Zhi-hong,YANG Xing-gang,PAN Wei-san(School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China);Intestinal absorption kinetics of flurbiprofen in rats[J];药学学报;2013-03
5 LIU Gang-yi~1,WANG Wei~1,ZHANG Meng-qi~1,LU Chuan~1,WANG Hong-yi~2,LIU Yun~1,JIA Jing-ying~1,YU Chen~1 (1.Central Laboratory,Shanghai Xuhui Central Hospital,SHANGHAI 200031,China;2.Department of Analytical Chemistry,SemiBio Technology Co.,Ltd.,SHANGHAI 201615,China);Quantitation of huperzine A in human plasma by LC - MS/MS for elderly population[J];中国新药与临床杂志;2012-12
6 WEI Zhen-man1,DING Jin-biao1, HU Lin1,CHEN Hong-ge2, WU Rong-rong1,LIU Wan-hui2, SHA Chun-jie2 (1.Department of Clinical Pharmacology,No.of 302 Hospital of PLA,Beijing 100039,China;2.College of Pharmacy,Yantai University,Yantai 264005,Shandong Province,China);Bioequivalence of huperzine A sustain-release tablets in healthy volunteer[J];中国临床药理学杂志;2012-01
7 WU Ting,ZHANG Jun,CHU Ji-hong,JU Wen-zheng,XU Mei-juan,CHEN Min,TAN Heng-shan.Department of Clinical Pharmacology,the Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Jiangsu 210029,China;Determination of huperzine A in huperzine A sustained-release patches by high performance liquid chromatography(HPLC)[J];中国药物与临床;2011-09
8 Wei Zhenman1,Ding Jinbiao1,Hu Lin1,Chen Hongge1,Wu Rongrong1,Liu Wanhui2,Sha Chunjie2(1.Department of Clinical Pharmacology,302 Hospital,PLA,Beijing,China 100039;2.College of Pharmacy,Yantai University,Yantai,Shandong,China 264005);Effect of Food Intake on Pharmacokinetics of Huperzine A Sustained-Release Tablets in Healthy Volunteers[J];中国药业;2011-17
9 WU Ting1,ZHANG Jun1,XU Mei-juan1,JU Wen-zheng1,TAN Heng-shan2(1.Department of Clinical Pharmacology,Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Nanjing JIANGSU 210029,China;2.General Hospital of Nanjing Military Command of PLA,Nanjing JIANGSU 210002,China);Comparative pharmacokinetics of huperzine A sustained-release patches and tablets in normal volunteers[J];中国新药与临床杂志;2011-08
10 HU Jiang-ning,QU Wei,CHEN Ling-fang,HE Hou-hong (Zhejiang Institute of TCM&Natural Drug Co.,Ltd.Hangzhou 310052,China);PhaseⅠclinical tolerability trial of Huperzine A sustained-release patch[J];世界临床药物;2011-06
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 YANG Wu;HOU Jia;LU Yuan;CHEN Peng-cheng;LIAO Shang-gao;HUANG Yong;Guizhou Provincial Key Laboratory of Pharmaceutics,Guizhou Medical University;School of Pharmacy,Guizhou Medical University;Engineering Research Center for the Development and Application of Ethnic Medicine and Traditional Chinese Medicine[Ministry of Education],Guizhou Medical University;;Intestinal absorption kinetics of Polygonum capitatum extract in rats[J];中国中药杂志;2015-21
2 LIU Qiu-yan;FANG Guo-shan;LIU Xiong;LIN Ju-chun;College of Veterinary Medicine,Sichuan Agricultural University;College of Food Science,Southwest University;;In vivo absorptive dynamics of Zanthoxylum alkylamide in rat intestines[J];西北农林科技大学学报(自然科学版);2015-08
3 ZHANG Ke-xia;JIANG Yu;CHEN Xiao-hui;School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University;School of Pharmacy,Shenyang Pharmaceutical University;;Research progress on flavonoids phospholipid complex[J];沈阳药科大学学报;2015-05
4 XU Bin;Department of Pharmacy, Wuhan Donghu Hospital;;Research progress in ion-exchange resin in pharmaceutical preparation[J];中南药学;2015-05
5 SUN Yu;WANG Jian;XIAO Xue-feng;Department of Pharmacy,Baokang Affiliated Hospital of Tianjin University of Traditional Chinese Medicine;Department of Pharmacy,Tianjin Children's Hospital;;Intestinal absorption dynamics on methyl nonyl ketone in volatile oil from houttuynia cordata[J];天津医科大学学报;2015-02
6 YANG Peimin;CAO Guangshang;LI Fang;Affiliated Hospital of Shandong University of Traditional Chinese Medicine;College of Pharmacy,Shandong University of Traditional Chinese Medicine;;Intestinal Absorption of Hypericum Perforatum Flavonoids in Rats in vivo[J];中华中医药学刊;2015-03
7 TAN Cong;XUE Shi-jiao;LI Bo;ZHANG Qi-chun;PAN Lin-mei;DUAN Jin-ao;ZHU Hua-xu;GUO Li-wei;Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,Jiangsu Refinement Engineering Research Center of Botanical Medicine, Nanjing University of Chinese Medicine;;Intestinal Absorption Analysis of Huanglian Jiedu Tang Based on Theory of Correspondence Between Syndrome and Prescription[J];中国实验方剂学杂志;2015-05
8 DONG Ling;XIANG Jia-mei;WANG Yun;WU Rui-guang;TANG Ming-min;SUN Mo-han;Beijing University of Chinese Medicine;;Design and analyze mathematical algorithms of intestinal absorption and metabolism of multicomponent drug[J];中国中药杂志;2014-23
9 Li Houyang;Wu Kaihui;Department of Pharmacy,the First People's Hospital of Changde;;Preparation and Quality Control of Levodropropizine Buccal Tablets[J];中国药师;2014-07
10 GUO Na;ZHU Mei-xuan;HAN Xue-jiao;YANG Qian;School of Municipal and Environmental Engineering,Harbin Institute of Technology;Alkali Soil Natural Environmental Science Center,Northeast Forestry University;Key Laboratory of Saline-alkali Vegetation Ecology Restoration in Oil Field,Ministry of Education;School of Life Science and Technology,Harbin Institute of Technology;;Advances in studies on intestinal absorption kinetics of phenolic glycosides[J];中国生化药物杂志;2014-03
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Mao Fengfei Tu xide Zhu Jiabi Zhao Luhua and Hu Zhenze (Department of Pharmaceutics);ABSORPTION OF BAICALIE IN SMALL INTESTINE OF RAT[J];南京药学院学报;1984-01
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved