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《Central South Pharmacy》 2008-05
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Phase diagram of etoposide microemulsion

WANG Xing-lin1,2,YIN Dong-dong2,ZHANG Jun-wei2(1.School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072;2.Tianjin Institute of Pharmaceutical Research,Tianjin 300193)  
Objective To develop the o/w etoposide microemulsion formulation.Methods Oleic acid,isopropyl myristate and isopropyl palmitate were chosen for oils.Tween 80,Cremophor EL and Cremophor RH40 were selected as surfactants.Ethanol,isopropyl alcohol,1,2-propylene glycol,glycerin and PEG 400 were used as cosurfactants.The pseudotertiary phase diagrams were obtained by titration.The formulation was screened by the o/w microemulsion area.Results The final blank microemulsion formulation was:cremophor RH40∶ethanol∶PEG 400∶isopropyl miristate∶water=19.0∶19.0∶19.0∶38.2∶4.8.Conclusion The defined microemulsion formulation can be used to carry etoposide.
【Fund】: “国家科技支撑计划”子课题 新型载体给药系统及其成药性综合评价关键技术与应用研究(项目编号:2007BAI41B05)
【CateGory Index】: R94
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