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《Central South Pharmacy》 2014-02
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Determination of notopterol, isoimperatorin, costunolide and dehydrocostuslactone in Chenxiangqu by HPLC

XU Hong-li;ZHANG Ming;HE Sheng-li;Hubei Xiaogan Recovery Hospital;Tianjin Pharmaceutical Group Xinzheng Co., Ltd.;  
Objective To develop an HPLC method for the content determination of notopterol, isoimperatorin, costunolide and dehydrocostuslactone in Chenxiangqu. Methods An Hypersil C18 column was used as the chromatographic column, and the flow rate was 0.9 mL · min- 1. Notopterol and isoimperatorin: the mobile phase consisted of acetonitrile-0.5% phosphoric acid solution(67 :33). The UV detection wavelength was 312 nm. Costunolide and dehydrocostuslactone: the mobile phase consisted of acetonitrile-methanol-1% acetic acid solution(45 :24 :31). The UV detection wavelength was 225 nm. Results There was a good linearity between the concentration of notopterol, isoimperatorin and peak area value when the concentrations of notopterol and isoimperatorin were at 0.018 6- 0.372 0 μg(r = 0.999 2) and 0.011 2- 0.224 0 μg(r = 0.999 1). The average recovery was 96.6%(RSD = 1.6%) and 98.0%(RSD = 1.2%). There was a good linearity between the concentration of costunolide, dehydrocostuslactone and peak area value when the concentrations of costunolide and dehydrocostuslactone were at 0.041 4- 0.828 0 μg(r = 0.999 5) and 0.010 8- 0.216 0 μg(r = 0.999 7). The average recovery was 98.0%(RSD = 1.4%) and 96.2%(RSD = 1.1%). Conclusion The method is accurate, sensitive, reproducible and can be used in the determination of notopterol, isoimperatorin, costunolide and dehydrocostuslactone in Chenxiangqu.
【CateGory Index】: R284.1
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