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《Chinese Journal of Bases and Clinics in General Surgery》 2010-01
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Value of ~1H-MR Spectroscopy for Quantification of Hepatic Steatosis on 3.0 T MR System

ZHAO Li-ming,SONG Bin,CHEN Guang-wen,YUAN Fang,HUANG Zi-xing,YANG Nin-jing.Department of Radiology,West China Hospital,Sichuan University,Chengdu 610041,China  
Objective To investigate the diagnostic value of proton magnetic resonance spectroscopy(1H-MRS) on the quantification of hepatic steatosis at 3.0 T MR united.Methods Twenty-two patients who were candidated for liver surgery(living liver transplantation donor candidates,lobectomy or segmental resection for focal liver diseases,etc.) were enrolled in this study.1H-MRS was conducted with point resolved selective spectroscopy(PRESS) sequence,using SAGE software packages.The values of water peak(PW),lipid peak(PL) were measured,the area under water peak(AW) and lipid peak(AL),and then the relative lipid content of liver cells(RLC1,RLC2) was calculated.All subjects underwent surgical resection of liver shortly after MR scanning,fresh frozen specimens were obtained for Sudan Ⅲ staining,and staging was conducted.Results In all 22 patients,7 patients without fatty liver,11 patients with mild fatty liver,4 patients with moderate or severe fatty liver.Inter-comparison between different histopathological grades showed following findings: the values of PL,AL,RLC1 and RLC2 had statistical significance(P0.05).The values of PL,AL,RLC1 and RLC2 were positively correlated with the proportion of fatty degenerative cells(PFDC),P0.05,and the highest correlation factor was 0.771(RLC1 to the PFDC).Conclusion 1H-MRS can accurately quantify liver fat content and reflect the severity of hepatic steatosis.It has the potential to replace invasive liver biopsy.
【Fund】: 国家自然科学基金项目(项目编号:30770622)~~
【CateGory Index】: R575.5;R445.2
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【References】
Chinese Journal Full-text Database 4 Hits
1 LI Xiaojiao;ZHAO Jiannong;TANG Zhuoyue;Department of Radiology,The Second Affiliated Hospital of Chongqing Medical University;;The Comparative Study of the Follow up Value of 3. 0 T ~1H-MRS and Ultrasonography in Nonalcoholic Fatty Liver Disease[J];临床放射学杂志;2015-09
2 SUN Bo,LIU Ailian;Progresses of MR technology in evaluating steatosis of non-alcoholic fatty liver[J];国际医学放射学杂志;2012-01
3 JIANG Ming-jun,ZHANG Ling-nan;Progress in Magnetic Resonance Spectroscopy for Liver[J];中国肿瘤;2011-08
4 Liver LU Siyuan,WANG Yucheng,WANG Xinyi.Department of Gastroenterology,Central Hospital of Xuhui District,Shanghai(200031);Cross-sectional Study on Association between Body Fat Mass to Fat-free Mass Ratio and Nonalcoholic Fatty[J];胃肠病学;2011-06
【Citations】
Chinese Journal Full-text Database 7 Hits
1 SU Zhong-zhen1, SHAN Hong1, HE Bing-jun1, LV Wen-tian1, MENG Xiao-chun1, WANG Jin1, ZHU Kang-shun1, YANG Yang2, CHEN Gui-hua2(1. Department of Radiology; 2. Department of Liver Transplantation, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China);Comparison on the values of STEAM and PRESS sequences in ~1H MRS quantitative evaluation of fatty liver[J];中国介入影像与治疗学;2008-02
2 LIANG Chang-hong LIU Yu-bao ZHANG Zhong-lin XIE Shu-fei WANG Qiu-shi. Department of Radiology,Guangdong Provincial People's Hospital,Guangzhou 510080,China;Initial study of quantitative analysis of fatty liver by ~1H-MR spectroscopy imaging[J];中华放射学杂志;2007-01
3 ;Advanced research on alcoholic liver disease[J];吉林大学学报(医学版);2006-04
4 ZHENG Rui-dan,LU Lun-gen,MENG Jia-rong,HUANG Jun-da,RAO Ri-chun,XU Cheng-run,ZENG Min-de.Department of Gastroenterology,Renji Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200001,China;A clinical and pathological study of nonalcoholic fatty liver disease[J];中华肝脏病杂志;2006-06
5 FAN Ming-xia, TIAN Jian-ming, LU Jian-ping, JIN Ai-guo, ZENG Hao (Department of Radiology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China);Preliminary evaluation of fatty liver in rats by in vivo ~1H MR spectroscopy[J];中国医学影像技术;2004-10
6 ZHUANG Hui. [First author's address] Department of Microbiology, Peking University Health Science Center, Beijing 100083, China;Epidemiology of alcoholic liver diseases.[J];中华肝脏病杂志;2003-11
7 LI You-ming, CHEN Wei-xing, YU Chao-hui, YUE Min, LIU You-shi, XU Gen-yun, JI Feng, LI Su-dan. Department of Gastroenterology, First Affiliated Hospital, Medical School, Zhejiang University, Hangzhou 310003, China;An epidemiological survey of alcoholic liver disease in Zhejiang province[J];中华肝脏病杂志;2003-11
【Co-references】
Chinese Journal Full-text Database 2 Hits
1 LI Shuang(School of Art JiangXi University of Finance and Economics,NanChang JiangXi 330013);Analysis of Measures to Promote the Development of China's Digital Music Industry[J];价格月刊;2012-05
2 WANG Jia-ning(Beijing Institute of Graphic Communication,School of Publishing Communication and Management,Beijing 102600,China);The Development of Chinese Digital Music Industry from the Point of View of Industry Value Chain[J];信阳师范学院学报(哲学社会科学版);2009-01
【Secondary Citations】
Chinese Journal Full-text Database 6 Hits
1 LI Ping,DI Hui (Business School of Renmin University,Beijing 100872,China);Research on Value-determinants in Modularized Restruction of Industrial Value Chain[J];中国工业经济;2006-09
2 LV Yan-zhao(Economics and Management School,Harbin Engineering University,Harbin,Heilongjiang 150001,China);The Influence of Industrial Value Chain Layout on China's Mid-west Area[J];商业研究;2006-12
3 DU Xiao-jun,ZHANG Dan-ning(School of Business Administration,Northeastern University,Shenyang 110004,China);Research on Technology Learning of Industrial Value Chain Cluster[J];东北大学学报(社会科学版);2006-02
4 DU Yi-fei, LI Shi-ming (School of Management, University of Electronic and Science Technology of China, Chengdu 610054, China);Industrial value chain:the innovative format of value strategy[J];科学学研究;2004-05
5 LU Ming-hua, LI Guo-ping (School of Government, Peking University, Beijing100871, China);The Development of Global Electronic and Information Industrial Value-Chain and Its Revelation[J];北京大学学报(哲学社会科学版);2004-04
6 YANG Kai-yun,YIN Liu-ying (College of Industrial and Business Adminstration,South China Technolo gical Univ.,Guangzhou 510640,P.R.China);On the Advantages of Small and Medium Enterprises in Strategic Outsourcing from the Pe rspectve of Value Chains[J];深圳大学学报(人文社会科学版);2001-05
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