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《Chinese Journal of Bases and Clinics in General Surgery》 2010-01
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Value of ~1H-MR Spectroscopy for Quantification of Hepatic Steatosis on 3.0 T MR System

ZHAO Li-ming,SONG Bin,CHEN Guang-wen,YUAN Fang,HUANG Zi-xing,YANG Nin-jing.Department of Radiology,West China Hospital,Sichuan University,Chengdu 610041,China  
Objective To investigate the diagnostic value of proton magnetic resonance spectroscopy(1H-MRS) on the quantification of hepatic steatosis at 3.0 T MR united.Methods Twenty-two patients who were candidated for liver surgery(living liver transplantation donor candidates,lobectomy or segmental resection for focal liver diseases,etc.) were enrolled in this study.1H-MRS was conducted with point resolved selective spectroscopy(PRESS) sequence,using SAGE software packages.The values of water peak(PW),lipid peak(PL) were measured,the area under water peak(AW) and lipid peak(AL),and then the relative lipid content of liver cells(RLC1,RLC2) was calculated.All subjects underwent surgical resection of liver shortly after MR scanning,fresh frozen specimens were obtained for Sudan Ⅲ staining,and staging was conducted.Results In all 22 patients,7 patients without fatty liver,11 patients with mild fatty liver,4 patients with moderate or severe fatty liver.Inter-comparison between different histopathological grades showed following findings: the values of PL,AL,RLC1 and RLC2 had statistical significance(P0.05).The values of PL,AL,RLC1 and RLC2 were positively correlated with the proportion of fatty degenerative cells(PFDC),P0.05,and the highest correlation factor was 0.771(RLC1 to the PFDC).Conclusion 1H-MRS can accurately quantify liver fat content and reflect the severity of hepatic steatosis.It has the potential to replace invasive liver biopsy.
【Fund】: 国家自然科学基金项目(项目编号:30770622)~~
【CateGory Index】: R575.5;R445.2
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