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《Chinese Journal of Bases and Clinics in General Surgery》 2014-07
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Value on Survival Prediction of The Changes of AFP and sICAM-1 Before and after Surgical Treatment of Hepatocellular Carcinoma

CHEN Yu;CAO Da-yong;LI Xiao;Department of Hepatobiliary Surgery,Xijing Hospital,The Forth Military Medical University;Department of General Surgery,No.451 Hospital of PLA;  
Objective To study the clinical value of changes of serum α-fetoprotein(AFP) and soluble cell adhesion molecule-1(sICAM-1) levels before and after surgical treatment of primary hepatocellular carcinoma(PHC)as predictors of patient survival.Methods The clinical data and followed-up results of 86 patients with hepatocellular carcinoma,received hepatectomy or radiofrequeney ablation(RFA)in Xijing Hospital and the 451~(st) Hospital of PLA were retrospectivly analyzed.The changes of peripheral blood AFP and sICAM-1 levels in patients before and in 1 month after treatment were observed and all patients were divided into different groups according to the changes in both two markers.Then survival rates of each group were analyzed.Results The patients with AFP20μg/L or sICAM-11000 U/L before treatment had lower tumor recurrence rate and higher survival rate than patients with elevated serum levels of the both markers(AFP:P=0.018,P0.001;sICAM-1:P=0.027,P0.001).The larger tumor,late TNM stage,and higher rate of recurrence were associated with elevated serum levels of the both markers(AFP:P=0.016,P=0.026 and P=0.025;sICAM-1:P0.001,P=0.024 and P=0.032).The better survival situation was closely related with these cases treated with hepatectomy and their levels of both markers were lower than the above cutoff values both before and after treatment,or leves of both markers above the cut-off values returned to within the normal range after treatment(AFP:P=0.006,P=0.001;sICAM-1:P=0.001,P=0.002).The patients who had simultaneous increase of AFP and sICAM-1 after operation showed the worst tumor-free and overall survivals(P=0.007,P0.001).Conclusion To test the changes of serum AFP and sICAM-1 levers in early stage after treatment for patients who received radical resection of hepatocellular carcinoma has good clinical value for monitoring of tumor recurrence and predict prognosis.
【Fund】: 国家自然科学基金青年基金项目资助(项目编号:81201926)~~
【CateGory Index】: R735.7
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Chinese Journal Full-text Database 2 Hits
1 Cui Dapeng;Wang Yujia;Han Lei;Gao Shuquan;Liu Fei;Zhang Yingchun;Department of Hepatobiliary Surgery,First Affiliated Hospital of Hebei North University;;Relationship analysis of serum CA19-9,CEA,CA125 and sICAM-1with the diagnosis valuation and tumor metastasis of pancreatic cancer[J];国际外科学杂志;2018-01
2 YE Hong;Huiyang District Hospital of Traditional Chinese Medicine in Huizhou City;;Significance of combined detection of alpha fetoprotein, alpha fucosidase, beta 2-microglobulin and hyaluronic acid in the diagnosis of primary liver cancer[J];中国医药科学;2015-14
Chinese Journal Full-text Database 5 Hits
1 XU Lei-bo;WANG Jie;LIU Chao;Department of Hepatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University;;Comparison of Three Staging Systems in Prediction of Survival of Patients with Advanced Hepatocellular Carcinoma after Hepatectomy[J];中国普外基础与临床杂志;2014-02
2 ;Comprehensive Treatment for Primary Liver Cancer[J];中国普外基础与临床杂志;2014-02
3 ;Expression of ICAM-1 mRNA of Isolated Rat Liver after Preservation and Reperfusion and Effect of Salvia Miltiorrhiza on Its Expression[J];中国普外基础与临床杂志;2013-08
4 ZHAO Wei,DOU Kefeng,YUE Shuqiang,et al.Department of Hepatobillary Pancreas-spleen Surgery,Xijing Hospital,the Fourth Military Medical University,Xi′an 710033,China;Significance of detecting alpha-fetoprotein and soluble intercellular adhesion molecule-1 in the diagnosis of primary hepatocellular carcinoma[J];中华实用诊断与治疗杂志;2008-07
5 SUN Jing Jing, ZHOU Xin Da, ZHOU Ge and LIU Yin Kun;Expression of intercellular adhesive molecule 1 in liver cancer tissues and liver cancer metastasis[J];World Journal of Gastroenterology;1998-03
Chinese Journal Full-text Database 10 Hits
1 TIAN Yun-hong;YANG Hong-chun;PENG Yong;MA Hai;LI Yong;LI Guan-yin;Department of Hepatobiliary Surgery,Nanchong Central Hospital,The Second Clinical Hospital of North Sichuan Medical College;;The Impact of Antivirus on Prognosis after Liver Resection for Hepatitis B-Related Hepatocellular Carcinoma[J];中国普外基础与临床杂志;2015-10
2 GAO Fei;HAN Bin;PANG Zhi-gang;CHEN Wen-chao;Department of General Surgery,The Second Affiliated Hospital,Zhengzhou University;;Transcatheter Arterial Chemoembolization Combined with Sorafenib in Treatment of Intermediate or Advanced Hepatocellular Carcinoma of Chinese: A Meta Analysis[J];中国普外基础与临床杂志;2015-08
3 Jin Chao;Du Xilin;Lu Jianguo;Department of General Surgery,Tang Du Hospital,Fourth Military Medical University;;Prognostic evaluation of AFP in advanced hepatocellular carcinoma treated with sorafenib[J];现代肿瘤医学;2015-18
4 WANG Jun-shan;LU Jie;ZHOU Yin-qun;GUO Chuan-yong;Department of Gastroenterology,Shanghai Tenth Hospital,Tongji University;;Effect of sorafenib and other targeted drugs in liver cancer therapy[J];世界临床药物;2015-06
5 WANG Tao;QIU Mei-qing;Department of Oncology,Zaozhuang City Hospital;;Prognostic factors of hepatocellular carcinoma and cholangiocarcinoma[J];中华肿瘤防治杂志;2015-10
6 MA Jian-hong;WANG Xia;GONG Guiying;Liver Disease Department,Hebei Liver Ill Hospital of Traditional Chinese Medicine;;Observation of Danshen Qianggan capsule for the treatment of chronic hepatitis B liver fibrosis[J];河北中医;2015-03
7 JI Yong-shuo;ZHANG Yu;ZHU Ling-lin;ZHU Jun-qiu;ZHAO Hong;Department of HIFU Center,Huadong Hospital,Fudan University;;Short-term Clinical Effect of ~(125)I implantation on the elderly patients with primary liver cancer[J];老年医学与保健;2015-01
8 Feng-Qing Ji;Jing Teng;Qi-Zhong Zheng;Department of Clinical Laboratory, Xiamen Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine;Department of Pathology, Xiamen Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine;;Clinicopathologic significance and expression of serum alphafetoprotein variant in patients with primary liver cancer[J];世界华人消化杂志;2015-02
9 DAI Chao-liu;JIA Chang-jun;Department of Hepatobiliary & Splenic Surgery,Shengjing Hospital,China Medical University;;Algorithm of diagnosis and multidisciplinary treatment for hepatocellular carcinoma[J];中国实用外科杂志;2014-08
10 CHEN Yu;CAO Da-yong;LI Xiao;Department of Hepatobiliary Surgery,Xijing Hospital,The Forth Military Medical University;Department of General Surgery,No.451 Hospital of PLA;;Value on Survival Prediction of The Changes of AFP and sICAM-1 Before and after Surgical Treatment of Hepatocellular Carcinoma[J];中国普外基础与临床杂志;2014-07
Chinese Journal Full-text Database 10 Hits
1 WANG Jin-hua;ZHENG Xiu;CHEN Li-hong;LIN Li;HUANG Yan;Department of Obstetrics and Gynecology,the First Affiliated Hospital of Fujian Medical University;Department of Obstetrics and Gynecology, the No.2Hospital of Xiamen;Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center;;Study on the association between expression of serum squqmous cell carcinoma antigen,carbohydrate antigen 125 and cervical carcinoma stage[J];中国临床药理学杂志;2015-15
2 LI Xiao-ming;HU Ai-hong;ZHANG Fan;Department of Pharmacy,the First People's Hospital of Huzhou;Department of Chemotherapy, the First Affiliated Hospital of Fujian Medical University;;Effect and safety study of gemcitabine combined with tegafur in the treatment of advanced metastasis pancreatic cancer[J];中国临床药理学杂志;2015-04
3 Chuang-Jie Zhang;Lian-Feng Zhang;Lin Zhou;Department of Gastroenterology, the First Affiliated Hospital of Zhengzhou University;;Clinical significance of expression of autophagyrelated proteins Beclin1, LC3 and P62 in advanced pancreatic cancer[J];世界华人消化杂志;2015-02
4 CHEN Yu;CAO Da-yong;LI Xiao;Department of Hepatobiliary Surgery,Xijing Hospital,The Forth Military Medical University;Department of General Surgery,No.451 Hospital of PLA;;Value on Survival Prediction of The Changes of AFP and sICAM-1 Before and after Surgical Treatment of Hepatocellular Carcinoma[J];中国普外基础与临床杂志;2014-07
5 GAN Jian-chun;LIU Ning;WANG De-hou;General Surgery Ward 2,the Affiliated Hospital of Yan’an University;;Application value research of serum tumor markers CEA,CA19-9 and CA72-4 in gastric cancer[J];中华全科医学;2014-06
6 WU Hai-li.Department of Oncology,The First Affiliated Hospital of Chinese PLA General Hospital,Beijing 100037,China;Clinical study on oxaliplatin containing TACE treatment for primary liver cancer[J];临床和实验医学杂志;2013-11
7 YIN Cui-hong1,JIANG Long-feng2,YAN You-de2,ZHANG Cai-tian3,DANG Yi-ni2,LIU Qi-qin1,ZHOU Yu-song1,WU Yu-ying2,LIU Yan2(1 Jiangsu province Yizheng City People Hospital of infectious diseases,Yizheng,Jiangsu,211400,China;2 Jiangsu Province People's Hospital infection diseases,Nanjing,Jiangsu,210029,China;3 Jiangsu province Yizheng City People's Hospital of blood screening test department,Yizheng,Jiangsu,211400,China);Diagnostic Value on Primary Hepatocellular Carcinoma by the Detection of AFP,AFU,β_2-MG,CA199[J];现代生物医学进展;2012-36
8 ZHOU Xiao-hui(Department of Clinical Laboratory,the First People′s Hospital of Dafeng,Jiangsu 224100,China);The significance of combined dtection of AFP,CA199,and β_2-MG in diagnosis of primary carcinoma of liver[J];检验医学与临床;2012-05
9 CHEN Xiao-ling,JIAO Xiao-duo,WU Yong.Department of Agentia,Guangzhou First Municipal People's Hospital,Guangzhou Guangdong 510180,China;Detection and clinical significance of hyaluronic acid,laminin and collagen Ⅵ in plasma of liver cancer[J];临床和实验医学杂志;2010-14
10 WANG Xuping,GUO Lina,YANG Haiying.Department of Obstetrics and Gynecology,The Second Hospital Affiliated to China North College,Hebei,Zhangjiakou 075100,China;Clinical significance of serum sICAM-1 and P-selectin in patients with ovarian cancer at perioperative period[J];河北医药;2010-13
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 XU Qiu-ran,ZHENG Xin,YAO Ying-min,YANG Wei,LIU Qing-guang(Department of Hepatobiliary Surgery,the First Affiliated Hospital, Medical School of Xi'an Jiaotong University,Xi'an 710061,China);Liver transplantation versus resection for treatment of hepatocellular carcinoma: A meta-analysis[J];西安交通大学学报(医学版);2012-05
2 Tian Hao,Cheng Zhaohui,Zhang Ruigang,Zhuang Guangxia(Department of Oncology,the People's Hospital of Xinyi,Xinyi 221400,China);The Clinical Effect of FOLFOX4 Regimen in the Treatment of Patients with Advanced Hepatocellular Cancer[J];肿瘤基础与临床;2011-06
3 Ministry of Health of the People's Republic of China;Diagnosis,management,and treatment of hepatocellular carcinoma(V2011)[J];临床肝胆病杂志;2011-11
4 HAN Guo-hong,BAN Wei,LIANG Jie,YIN Zhan-xin,HE Chuang-ye,SONG Han-ge,WU Kai-chun,DING Jie,FAN Dai-ming.Department of Gastroenterology,the Affiliated Xijing Hospital to Fourth Military Medical University,Xi'an 710032,China;Clinical study of TACE combined sorafenib on advanced hepatocellular carcinoma[J];临床肿瘤学杂志;2009-05
5 Xiao-Ping Chen, Fa-Zu Qiu, Zai-De Wu, Bi-Xiang Zhang, Hepatic Surgery Center, Tongji Hospital Medical, College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China;Hepatectomy for huge hepatocellular carcinoma in 634 cases[J];World Journal of Gastroenterology;2006-29
6 WANG Luhua, FANG Linli,MAI Mang,et al.The First Affiliated Hospital of Shantou University Medical College,Shantou 515041,China;Serological relationship between primary hepatocellular carcinoma with positive alpha fetoprotein and hepatitis B virus infection[J];实用诊断与治疗杂志;2006-07
7 SHAO Zhe-xin, XU Xiao, ZHENG Shu-sen, LIANG Ting-bo, KE Qin-hong, MA Yi-ping. Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China;Serum α-fetoprotein alterations and tumor recurrence after liver transplantation for hepatocellular carcinoma patients[J];中华普通外科杂志;2006-05
8 Peng Yan;Lu-Nan Yan the Department of Surgery, Pittsburg Medical College of USA First People's Hospital of Chengdu, Chengdu 610041, China Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China;Staging of hepatocellular carcinoma[J];Hepatobiliary & Pancreatic Diseases International;2003-04
9 HUANG Ping,CHEN Qiang,ZHANG Qi zhong,et al. (Fujian Provincial Tumor Hospital 350014);Clinical Study on Injectio Arsenous Acid for Middle or Advanced Primary Liver Cancer[J];中国误诊学杂志;2002-11
10 MA Jingxiang, GONG Qilin , LIN Meiqing, et al. Department of Clinical Laboratory, Qianfoshan Hospital of Shandong Province, Ji′nan 250014, China. [WT5”HZ];Combined five tumor markers in detecting primary hepatic carcinoma[J];中华外科杂志;2000-01
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