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《Chinese Journal of General Surgery》 2004-07
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Detection of the expression of hTERT mRNA and telomerase activity of pancreatic juice in the diagnosis of pancreatic cancer

LIU Tao, WANG Chun-you, WAN Chi-dan, XIONG Jiong-xin,CAI Kai-lin (Department of General Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)  
Objective To study and evaluate the diagnostic and differencial diagnostic value of detection of human telomerase reverse transcriptase(hTERT) mRNA and telomerase activity in pancreatic juice of (pancreatic) cancer(PC) .Methods hTERT mRNA expression and telomerase activity in pancreatic juice in 24 cases of (pancreatic) cancer and 14 cases of chronic pancreatitis(CP) were detected and compared.Results Expression of hTERT mRNA was detected in 87 .5% (21/24) of PC cases and 21.4%(3/14) of CP cases(P0.001). Telomerase activity was positive in 83.3%(20/24) of PC cases and 28.6%(4/14) of CP cases (P0.001). Conclusions These results suggest that detection of hTERT mRNA and telomerase activity in pancreatic juice is helpful to the diagnosis of pancreatic cancer.
【CateGory Index】: R735.9
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