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《Chinese Journal of General Surgery》 2006-01
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A study of variation in micrometastasis in peripheral blood of patients with hepatocellular carcinoma before and after treatment by radio-frequency ablation

LI Jian,WANG Hong-lin,CHENG Xiang,TU Gang,WANG Ji-ming(Department of General Surgery,the first Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400010,China)  
Objective To assess whether clustered radiofrequency ablation(RFA) would lead to hematogenous dissemination of malignant cells in patients with primary hepatocellular carcinoma(PHC).Methods In 33 patients with PHC,the expression of AFPmRNA in peripheral blood before and after RFA treatment was(detected) by RT-PCR.Results Before RFA treatment,peripheral blood AFPmRNA was positive in 18 PHC patients(56.3%),and in the remaining 14 patients was negative(43.7%).However,positive expression of peripheral blood AFPmRNA was detected in 12 patients(37.5%) after RFA treatment.No significant difference of AFPmRNA expression was found before and after RFA tereatment(P0.05).Conclusions RFA treatment of PHC patients does not lead to hematogenous tumor dissemination.
【CateGory Index】: R735.7
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