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《Journal of Chongqing Medical University》 2004-04
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Induction of apoptosis in thyroid cells by iodide excess and its mechanism

LIU Dongfang,et al (Department of Endocrinology,College of Clinical Medicine,Chongqing Medical University)  
Objective:To explore the role of excessive iodide in inducing apoptosis in thyroid cells and its mechanism.Methods:Normal primary thyroid cells were cultured in NaI of different concentrations with or without IL-1β and methimazole.The morphological changes in thyroid cells were observed by light microscopy and apotosis rate was determined by flow cytometry techique.In the meantime Fas,FasL,p53 level were determined by histochemistry.Results:Thyroid cells treated with iodide excess underwent the morphological changes and apoptosis. There was a gradually increased apotosis rate and Fas/FasL protein expression accompanying increase in iodide concentrations.No changes in p53 protein expression was shown. IL-1β enhanced the effect of iodide cytotoxicity,whereas methimazole inhibited the role of iodide inducing apotosis.Conclusion:These data indicate that excess molecular iodide induces apoptosis in thyroid cell through Fas/FasL channel, but independent of p53.
【Fund】: 重庆市卫生局 ( 2 0 0 1-1-15 )
【CateGory Index】: R581.4
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【References】
Chinese Journal Full-text Database 5 Hits
1 CHEN Yu,LIU Dong-fang1*,YE Guo(Internal Medicine Department of Chongqing Cancer Institute,Chongqing 400030;1Department of Endocrinology,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China);The determination of apoptosis and expression of Fas /FasL in thyroid cells of AITD[J];南京医科大学学报(自然科学版);2010-05
2 TIE Li-li,ZHANG Ya-ping,WANG Ying-mei,et al.(Department of Endocrinology,Xijing Hospital,Fourth Military Medical University,710032,China);Effect of excess iodine on thyroid function and Trail expression in rats[J];西北国防医学杂志;2007-05
3 Xin CH,Gao TS,Yang WX,Li HM. 1Postgraduate School,Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning Province,China; 2Department of Endocrine,Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning Province,China; 3Shenyang Chinese Medical Hospital,Shenyang 110032,Liaoning Province,China;Effects of algae with iodine excess on thyroid cell apoptosis and apoptosis controlling gene[J];中国组织工程研究与临床康复;2007-38
4 HU Huai-dong,ZENG Xiao-hua,LIU Dong-fang,WANG Yu-junDepartment of Endocrinology,The Second Affiliated Hospital of Chongqing University of Medical Science,Chongqing 400010,China;The Different Sensitivity to Iodide Inducing Thyroid Cells Apoptasis of Normal and AITD Patients[J];西南师范大学学报(自然科学版);2006-01
5 LIN Lai-xiang, YE Zhen-kun, NIE Xiu-ling, YE Yan, YAN Yu-qin, CHEN Zu- pei. Institute of Endocrinology, Tianjin Medical University, Tianjin 300070 , China;Effect of iodine on the thyroid apoptosis and expressions of bax,bcl-2 mRNA in rats[J];中国地方病学杂志;2005-03
【Citations】
Chinese Journal Full-text Database 1 Hits
1 WU Yijie *,XIE Fukang,CAI Li,et al. *Department of Endocrinology,Shanghai First People's Hospital,Shanghai 200080;Effect of increasing iodine intake on incidence of hyperthyroidism[J];中华内分泌代谢杂志;2000-03
【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 ZHANG Ying-fei1,LI Le-qun2,YE Xin-ping1,QIN Xiao1,PENG Tao1,SU Ming1(1 Department of Hepatobiliary & Vascular Surgery,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China;2 Department of Hepatobiliary Surgery,Affiliated Tumor Hospital of Guangxi Medical University,Nanning 530021,China);Expression of Glucose-regulated Protein 78 and HSP60 in Primary Multifocal Hepatocellular Carcinoma and the Clinical Significance[J];广西医学;2010-01
2 Tan Xuyan,Wu Dan,Jia Yiqing,et al.Department of Ultrosonography,Jiangsu Cancer Hospital,Nanjing 20009,China;ANALYSIS ON EFFECT OF MULTI-METHODS INTERVENTIONAL TREATMENT FOR HEPATIC CANCER.[J];肝胆外科杂志;2002-04
3 Han Yunxue Zhu Kangsun Jiang Zaibo Ji Hua Hospital,Jilin,132021;The significance of preoperative TACE in preventing postoperative recurrence of primary hepatic carcinoma.[J];吉林医学院学报;1999-02
4 Zhan Shilin Chen Guozhong Huo Feng General Hospital of Guangzhou Unit,People' s Liberation Army,Guangzhou,510010;Study on hepatic arterial chemoembolization for preventing recurrence of small hepatocellular carci- noma after hepatectomy[J];中华肝胆外科杂志;1998-04
5 Tan Yun-shan,et al.Jiangxi Medical College.Nanchang,330006.;Residual liver cancer after transeatheter hepatic arterial chemoembolization in patients with large primary hepatic carcinoma[J];中华外科杂志;1992-06
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 CHEN Yin;WEI Jun-ping;Guang'anmen Hospital, China Academy of Chinese Medical Sciences;Beijing University of Chinese Medicine;;Commentary about research on Chinese materia medica applied in thyroid nodule therapy[J];中华中医药杂志;2015-12
2 CUI Peng,WANG Ying-na,GAO Tian-shu,QI Teng-che,MEI Lan,YIN Hui-si(Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China);Study on mechanism of traditional Chinese medicines reducing phlegm and resolving masses in treatment of goiter[J];中国中药杂志;2012-22
3 LI Xiamiao1,WANG Haijun3,PAN Shemian4,FU Jianfang1,SHI Yongquan1,LI Yuan2(1. Xijing Hospital,Fourth Military Medical University, Xi'an 710032, China; 2. School of stomatology, Fourth Military Medical University, Xian 710032,China;3. Yan'an People's Hospital,Yan'an 716000,China;4. Dongfang Hospital of Xian,Xian 710043,China);Effects of Huangbei Pingjia Capsules on Expressions of Bcl-2 and Bax in Mice with Graves' Disease[J];中药新药与临床药理;2012-04
4 XIAO Shuo,DING Zhuo-ling(The Affiliated Jingzhou Hospital,Tongji Medical School,Huazhong University of Science and Technology,Jingzhou 434020,China);Research on common traditional Chinese medicines treatment for Hashimoto′s thyroiditis[J];实用药物与临床;2012-03
5 LI Hongwei1,2,SONG Yan1,2,LI Li1,2,ZHANG Yuan1,LIN Laixiang2 (1.Department of Clinical Medicine,Tianjin Medical University,Tianjin 300070,China; 2.Institute of Endocrinology,Tianjin Medical University,Tianjin 300070,China);Effects of iodine on apoptosisand apoptosis-related proteins in the thyroid in rats of different sexes[J];中国体视学与图像分析;2011-03
6 Zhang Xiaozhi,Huang Tao,Hu Shifu(General surgery of Xiqing Hospital of Tianjin City,Tianjin 300380,China);Research Progress of Autoimmune Thyroid Disease[J];哈尔滨医药;2010-05
7 TIAN Xiu-biao,DAI Yong-hong,YAN Yu-qin,et al;Expression of casepase-9 protein and UCP2 gene in renal tissues of rats with different degrees of iodine deficiency[J];第二军医大学学报;2009-11
8 CONG Jianni, LI Ge, LEI Xun ( Institute of Public Health, Chongqing University of Medical Sciences, Chongqing 400016, China);Study on the Relationship between Urine Iodine and sFas/sFasL in Blood of Patients with Autoimmune Thyroid Diseases[J];广东微量元素科学;2009-11
9 WANG TING-TING,YAN SHENG-LI (Department of Endocrinology,The Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,China);EFFECT OF SODIUM SELENITE ON EXPRESSIONS OF Caspase-3,Bcl-2,AND Bax OF EXPERIMENTAL AUTOIMMUNE THYROIDITIS[J];齐鲁医学杂志;2009-04
10 ZHANG Danying,LEI Yanxia,ZHAO Junjie,TAN Wuhong,et al.Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education,Xi'an Jiaotong University,Xi'an 710061,China;The change of certain biochemical indexes and apotosis protein (Fas/Fasl) expression in rat liver of selenium and iodine deficiency[J];卫生研究;2008-06
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