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《Journal of Chongqing Medical University》 2004-04
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Induction of apoptosis in thyroid cells by iodide excess and its mechanism

LIU Dongfang,et al (Department of Endocrinology,College of Clinical Medicine,Chongqing Medical University)  
Objective:To explore the role of excessive iodide in inducing apoptosis in thyroid cells and its mechanism.Methods:Normal primary thyroid cells were cultured in NaI of different concentrations with or without IL-1β and methimazole.The morphological changes in thyroid cells were observed by light microscopy and apotosis rate was determined by flow cytometry techique.In the meantime Fas,FasL,p53 level were determined by histochemistry.Results:Thyroid cells treated with iodide excess underwent the morphological changes and apoptosis. There was a gradually increased apotosis rate and Fas/FasL protein expression accompanying increase in iodide concentrations.No changes in p53 protein expression was shown. IL-1β enhanced the effect of iodide cytotoxicity,whereas methimazole inhibited the role of iodide inducing apotosis.Conclusion:These data indicate that excess molecular iodide induces apoptosis in thyroid cell through Fas/FasL channel, but independent of p53.
【Fund】: 重庆市卫生局 ( 2 0 0 1-1-15 )
【CateGory Index】: R581.4
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