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《Journal of Chongqing Medical University》 2009-03
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The differential expression of VEGF165b in the renal cell carcinoma and normal renal tissues and its clinical significance

JIANG Cui-ping,et al (Department of Urology,the First Affiliated Hospital,Chongqing Medical University)  
Objective:To investigate the differential expression of VEGF165b in the renal cell carcinoma (RCC) and normal renal tissues and its role in the development of RCC. Methods: S-P immunohistochemistry was used to detect the expression of VEGF165b protein in 30 specimens of paraffin-embedded RCC tissues and 29 specimens of paraffin-embedded normal renal tissues. RT-PCR was performed to detect the expression of VEGF165b mRNA in 32 specimens of fresh RCC tissues and 30 specimens of fresh normal renal tissues. Results: Among 29 of normal renal tissues,28 specimens had positive expression of VEGF165b protein,with the positive rate of 96.55%(28/29) that was significantly higher than 20.00%(6/30)in RCC tissues(P0.05). The positive rate of VEGF165b mRNA in normal renal tissues was 93.33%(28/30),while that of RCC tissues was only 18.75%(6/32). The positive expression rate of VEGF165b mRNA in RCC tissues was significantly lower than that in normal renal tissues (P0.05). Conclusion: VEGF165b might play a role in inhibiting development ofRCC. Vascular endothelial growth factor 165b,
【Fund】: 重庆市自然科学基金资助项目(CSTC2005BB5033)
【CateGory Index】: R737.11
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