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《Journal of Chongqing Medical University》 2010-02
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Effects of total glucosides of paeony on the expression of IFN-γ,TNF-αand IL-10 in the rat model for chronic abacterial prostatitis

WANG Hong-zhi,et al (Department of Urology,the First Affiliated Hospital,Chongqing Medical University)  
Objective:To investigate the influence of TGP on IFN-γ,TNF-αand IL-10 in prostatic tissue of CAP rats.Methods:40 aged sprague dawley rats were randomly divided into four groups:the control group(10 rats),the rat model for CAP group(10 rats),the rat model for CAP treated with low dose TGP group(10 rats)and the rat model for CAP treated with high dose TGP group(10 rats).The changes of prostate gland inflammation was investigated by HE stain.The expression of IFN-γand TNF-αin rat prostatic tissue was detected by immunohistochemistry(sp).The expression of IL-10 in rat prostatic tissue was detected by enzyme linked immunosorbent assay(ELISA).Results:(1)The changes in histopathology in the animal model were similar to those in clinical CAP and the inflammation of treatment group obvious change for the better;(2)The IFN-γ,TNF-αand IL-10 in the rat model for CAP group were higher than the control group;(3)The IFN-γ,TNF-αand IL-10 expression reduces along with the TGP dosage increases in the rat model for CAP (P0.01);(4)Between each group the IFN/IL-10 and TNF/IL-10 have statistics significance(P0.01).Conclusion:TGP has therapeutic effects on CAP rats.The mechanisms may be associated with its ability to ameliorate the abnormal immunological functions and cytokine secretion in CAP rats.
【CateGory Index】: R285.5
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