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《Journal of Chongqing Medical University》 2010-09
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The damage of hyperglycemia to the neurons following traumatic brain injury

WANG Liang,et al (Department of Neurosurgery,the First Affiliated Hospital,Chongqing Medical University)  
Objective:To explore the damage of hyperglycemia to the neurons.Methods:Adult male SD rats were randomly divided into 3 groups:normal control group,traumatic brain injury group and insulin treated group,the blood glucose concentrations of the rats were measured before injury and when they were killed.The method of RT-PCR was applied to detect the expression of GLUT-3 genes.The change of GLUT-3 protein was detected by western-blot.The changes of NSE and NSE positive-Staining cells were examined by immunofluorescence staining Longa,balance test and screen test score were used to assess neural fnuctional defect.Results:The blood glucose concentration only increased markedly in traumatic brain injury group.through the expression of GLUT-3 and single cell NSE increased in the injured cortical both in traumatic brain injury group and insulin treated group,there was much more expression of GLUT-3 and single cell NSE but less NSE positive-Staining cells and neural functional defect in the insulin treated group at 12,24,48,72 h after injury.Meanwhile there were no changes were found in the uninjured side of each group.Conclusion:The hyperglycemia after traumatic brain injury increased the damage to the neurons by decreasing the expression of GLUT-3.
【CateGory Index】: R651.1
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【References】
Chinese Journal Full-text Database 1 Hits
1 JIANG Cheng-ping1,WANG Bai-qiang1,LIU Fu1,LI Yi1,YANG Ming1,ZHOU Yue1,WU Bi-hua2(1.Department of Pharmacology,Affiliated Hospital of North Sichuan Medical College,Sichuan Nanchong 637007,China;2.Neurology Research Institute,North Sichuan Medical College,Sichuan Nanchong 637007,China);Effect of Shenfu injection on GLUT1 and GLUT3 after cerebral ischemia-reperfusion injury in rats[J];中国医院药学杂志;2013-06
【Citations】
Chinese Journal Full-text Database 2 Hits
1 LIU Yuan, WANG Li, ZENG Lin, et al . Research Institute of Field Surgery, Chongqing 400042, China;Establishment of Model of Traumatic Brain Injury by an Improved Method in Rats[J];中国临床神经外科杂志;2008-07
2 LIU Ke1,2,TANG Wen-yuan1(1Department of Neurosurgery,The First Affiliated Hospital,Chongqing Medical University,Chongqing 400016;2Department of Neurosurgery,Chongqing Emergency Medical Center,Chongqing 400014,China);Experimental study on hemodynamics of traumatic brain injury using dynamic CT perfusion image[J];第三军医大学学报;2008-13
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Fu Junfei;Bian Ge;Li Min;Ningxia Medical University;;Influence of Cranioplasty in Different Surgical Time on Cerebral Hemodynamics[J];医学研究杂志;2015-05
2 SHEN Xia-feng;WU Jun-fa;YU Hui-xian;Department of Rehabilitation,Shanghai First Rehabilitation Hospital;;A focal brain trauma model for rehabilitation study[J];中国康复;2014-03
3 MO Li-dong1,HUANG Hui-ling,ZHANG Xue-bin,CHANG Xiao-li,WANG Chen,FAN Wei-jia(1 Institute of Neurosurgical Research,Tianjin Huanhu Hospital,Tianjin 300060,P.R.China);Effect of taurine on cerebral blood flow of rats with acute severe traumatic brain injury[J];山东医药;2012-09
4 YAO Yanpeng,ZHANG Xinding,HAN Yanming,et al. Department of Neurosurgery,Second Clinical Hospital of Lanzhou University,Lanzhou,730000;The effects of hyperbaric oxygen therapy on neuron apoptosis and apoptosis-related genes after traumatic brain injury in rats[J];中国康复医学杂志;2011-02
5 LIU Ke,FANG Bo,HU Xi,CHEN Kai-min,ZOU Sheng-wei(Department of Neurosurgery,Chongqing Emergency Medical Center,Chongqing 400014,China);Clinical application of CT perfusion imaging in traumatic brain injury[J];创伤外科杂志;2010-06
6 WANG Liang,et al (Department of Neurosurgery,the First Affiliated Hospital,Chongqing Medical University);The damage of hyperglycemia to the neurons following traumatic brain injury[J];重庆医科大学学报;2010-09
7 Deng Yongbing1,2,Tang Wenyuang1(1Department of Neurosurgery,First Affiliated Hospital,Chongqing Medical University,Chongqing,400016;2Department of Neurosurgery,Chongqing First Aid Medical Center,Chongqing,400014,China);Effect of pioglitazone on nerves of rats following traumatic brain injury[J];第三军医大学学报;2010-15
8 WANG Liang,TANG Wen-yuan,YANG Gang,et al.(Department of Neurosurgery,First Affiliated Hospital,Chongqing Medical University,Chongqing 400016,China);Effect of hyperglycemia on the expression of glucose transporter 3 in rats following traumatic brain injury[J];重庆医学;2010-12
9 WANG Liang,CHENG Liang,LI Dong,TANG Wenyuan.Department of Neurosurgery,First Affiliated Hospital,Chongqing Medical University,1 Yixueyuan Road,Chonqing 400016,China.;The influence of hyperglycemia on the neurons following traumatic brain injury.[J];中国神经精神疾病杂志;2010-06
10 WANG Liang,TANG Wenyuan,SUNG Xiaochuan,DENG Luping,LI Dong. Department of Neurosurgery,First Affiliated Hospital,Chongqing Medical University,1 Yixueyuan Road,Chonqing 400016,China.;The effect of hyperglycemia on the expression of glucose transporter 1 in rats following traumatic brain injury[J];中国神经精神疾病杂志;2010-01
【Co-references】
Chinese Journal Full-text Database 5 Hits
1 JIANG Cheng-ping1,LIU Fu1,LI Yi1,WANG Bai-qiang1,TANG Xiao-rong1,WU Bi-hua2,WANG Xiao-ming2(1.Department of Pharmacology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637007,China;2.Neurology Research Institute,North Sichuan Medical College,Nanchong 637007,China);Effect of Shenfu Injection on MDA,SOD,TXB_2 and 6-keto-PGF1a after Cerebral Ischemia/Reperfusion Injury in Rats[J];中国医科大学学报;2012-02
2 WANG Liang,et al (Department of Neurosurgery,the First Affiliated Hospital,Chongqing Medical University);The damage of hyperglycemia to the neurons following traumatic brain injury[J];重庆医科大学学报;2010-09
3 WANG Liang,TANG Wenyuan,SUNG Xiaochuan,DENG Luping,LI Dong. Department of Neurosurgery,First Affiliated Hospital,Chongqing Medical University,1 Yixueyuan Road,Chonqing 400016,China.;The effect of hyperglycemia on the expression of glucose transporter 1 in rats following traumatic brain injury[J];中国神经精神疾病杂志;2010-01
4 LEI Jun-rong,QIN Jun,ZHANG Jing,HUANG Kuan-ming,FU Rui,ZHOU Zhang-ming (Taihe Hospital,Yunyang Medical College,Shiyan Hubei 442000,China);Effects of curcumin on inflammatory reaction and blood-brain barrier permeability in rats following cerebral ischemic injury[J];中国药理学通报;2010-01
5 DONG Wen-peng,ZHANG Xiang,GAO Da-kuan,ZHEN Hai-ning,LI Bin,CAO Lei,LIN Hong,HUO Jun-li(Institute of Neurosurgery,Xijing Hospital,Fourth Military Medical University PLA,Xi'an 710032,China);Resveratrol's effect on acute phases of focal cerebral ischemic injury in mice[J];中国药理学通报;2008-08
【Secondary References】
Chinese Journal Full-text Database 2 Hits
1 Lyu Yanni;Fu Longsheng;Peng Hongwei;Sun Xiaochun;Zhong Haili;The First Affiliated Hospital of Nanchang University;;Protective effect and mechanism of Shenfu injection on the oxidaitve damage in PC12 cells induced by H_2O_2[J];国际中医中药杂志;2016-04
2 LYU Yan-ni;FU Long-sheng;ZHOU Jian;CAI Jun;CHEN Xuan-ying;ZHONG Hai-li;Department of Pharmacy,the First Affiliated Hospital of Nanchang University;;Action Mechanism of Shenfu Injection by Computational System Biology Analysis[J];中国实验方剂学杂志;2015-21
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 HU De-zhi, ZHOU Liang-fu, WU Xue-hai. Department of Neurosurgery, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China Corresponding author: ZHOU Liang-fu;Behavioral assessment of acute suction traumatic brain injury rat model[J];中华创伤杂志;2005-03
2 LIU Xiang, DAI Jianping, SUN Bo, et al Department of Neuroradiology, Beijing Neurosurgical Institute, Beijing 100050;The preliminary research of CT perfusion imaging in intraaxial ischemic disease[J];中华放射学杂志;1999-07
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