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《Journal of Chongqing Medical University》 2015-03
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Effects of different sevoflurane treatments on level of oxidative stress for thoracic surgery patients with one lung ventilation

Zhang Hongqin;Xiao Wei;Jiang Chunxiu;Zhang Jing;Department of Anesthesiology,the Third People Hospitals of Chongqing;Department of Thoracic Surgery,the Third People Hospitals of Chongqing;  
Objective:To study that the effect of different sevoflurane treatments on level of oxidative stress for thoracic surgery patients with one lung ventilation(OLV). Methods:Totally 80 patients undergoing thoracic surgery with OLV were randomly divided into four groups:propofol group(P group),sevoflurane pretreatment group(S1group),sevoflurane aftertreatment group(S2group) and sevoflurane whole-treatment group(S3group). Anesthesia of four groups was inducted with propofol. In P group,anesthesia was maintained with infusion of propofol and remifentanil. Anesthesia was treated for 30 min before OLV in S1 group and after OLV in S2 group. The patients in S3 group were treated for whole-progressing with 1.0 MAC sevoflurane. Blood samples were taken from radial artery before induction of anesthesia(baseline T0),before OLV(T1),at 30 min after OLV(T2)and at 24 h after OLV(T3). Meanwhile,bronchoalveolar lavage fluid was taken at T1 and T2. The content or activity of malondialdehyde(MDA),superoxide dismutase(SOD),lactate dehydrogenase(LDH)and nitric oxide(NO)in serum and bronchoalveolar lavage fluid were determined with chemical colorimetric method. Results:The levels or activity of MDA,SOD,LDH and NO in serum in each group were significantly increased at T2 and T3than at T0 and T1(P0.05). But the levels of MDA,LDH and NO were significantly decreased and the activity of SOD were obviously increased in S1-3groups than in P group(P 0.05),and there was no significant difference among S1,S2 and S3groups(P 0.05). After OLV 30 min(T2),the levels or activity of MDA,SOD,LDH and NO in serum in four groups were significantly increased at T2 and T3,compared with those at T0 and T1(P0.05). But the levels of MDA,LDH and NO were significantly decreased and the activity of SOD were obviously increased in S1-3groups than in P group(P0.05),and there was no significant difference in S1,S2 and S3groups(P0.05). Conclusion:Different sevoflurane treatments can decrease the content of MDA,LDH and NO,and increase the activity of SOD in serum and bronchoalveolar lavage fluid. The results suggest that sevoflurane possess potential for anti-oxidative stress injuries.
【Fund】: 重庆市卫生局科研基金资助项目(编号:2012-2-217)
【CateGory Index】: R614
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Chinese Journal Full-text Database 3 Hits
1 ZHAO Shuangping,WU Jiao,GUO Qulian,ZHANG Zhong,YE Zhi(Intensive Care Unit,Xiangya Hospital,Central South University,Changsha 410008,China);Effect of different concentrations of sevoflurane pretreatment on acute lung injury induced by endotoxin in rats[J];Journal of Central South University(Medical Science);2010-09
2 YOU Zhi-jian,XU Hong-xia,ZHOU Zi-chao,et al.Department of Anesthesiology,the First Affiliated Hospital of Medical College of Jiangsu University,zhenjiang 212001,Jiangsu,China;The Changes of Oxidative Stress after One-Lung Ventilation for Different Durations[J];Chinese Journal of General Practice;2010-12
3 RONG Jian1,YE Sheng2,JIANG Nan1,GUO Jun-ying1,WU Zhong-kai3,LIANG Meng-ya3,LIU Hai3,HUANG Wei-ming1,WANG Zhi-ping3(1.Dept of Anesthesiology,2.Dept of Oncology,3.Dept of Cardiac Surgery,the First Affiliated Hospital,SUN Yat-sen University,Guangzhou 510000,China);Sevoflurane postconditioning protects the lung against ischemia-reperfusion injury with CPB by downregulating RAGE[J];Chinese Pharmacological Bulletin;2010-06
Chinese Journal Full-text Database 10 Hits
1 CHEN Xi-hua,HUANG Bing,LI Yang,RUAN Lin,GU Yong-hui,YI Juan(Department of Anesthesia,Affiliated Tumor Hospital of Guangxi Medical University,Nanning 530021,China);Comparative Study of Two Different Ways of One-lung Ventilation on the Expression of AQP-5 in Rats[J];Guangxi Medical Journal;2011-04
2 WU Huo-zhi1,ZHANG Hao1,YUAN Mao-xi2,et al(1.Department of Cardiothoracic Surgery,The Fifth Affiliated Hospital of Zunyi Medical College,Zhuhai,Guangdong 519100,China; 2.Department of Cardiothoracic Surgery,Yishui Central Hospital,Linyi,Shandong 276400,China);Effects of captopril postconditioning on mRNA expression of angiotensinconvertion enzyme in lung ischemia-reperfusion injury in rats[J];Anhui Medical and Pharmaceutical Journal;2013-06
3 Liu Minxiao;Liu liyong;Yu Hailong;Department of Anesthesiology,the Fourth Hospital of Hebei Medical University;Department of Anesthesiology,the Friendship Hospital of Hebei;Department of Orthopedic,Raoyang ,TCM Hospital;;Effects of cytokines in patients undergoing esophageal surgery with one lung ventilationone though two different pattern[J];Chongqing Medicine;2014-15
4 Zhang Hongqin;Wang Diping;Li Ping;Xiao Wei;Xu Lu;Department of Anesthesiology,the Third People′s Hospital of Chongqing;Department of Anesthesiology,the First People′s Hospital of Chongqing;;The effect of sevoflurane pretreatment or aftertreatment on intrapulmonary shunt for patients with one lung ventilation during thoracic surgical procedures[J];Chongqing Medicine;2014-30
5 WANG Dong-xin;HOU Wen-jie;DIAO Shi-qi;KAN Hong-li;Department of Anesthesiology,Jilin Province Tumor Hospital;;Effect of sevoflurane preconditioning on inflammatory cytokines and oxygen radicals during one lung ventilation in patients with lung cancer[J];Journal of Clinical Anesthesiology;2013-09
6 PAN Guo-shi;HE Wen-sheng;ZHANG Jun;HU Yuan;Department of Anesthesiology,the Second People's Hospital of Hefei;;Effect of intravenous injection of edaravone on pulmonary function before one-lung ventilation[J];Journal of Clinical Pulmonary Medicine;2013-12
7 WU Xiao-qin,HUANG Zhao,WANG Si-rong,et al.ICU,First Municipal People's Hospital of Guangzhou,Guangzhou 510180,Guangdong,China;The Effects of Ginkgo Biloba Extract on Inflammatory Response and Oxidative Stress in ARDS[J];Chinese Journal of General Practice;2012-08
8 ZHANG Jun,HE Wen-sheng,HU Yuan,et al.Department of Anesthesiology,the Second People's Hospital of Hefei,Hefei 230009,Anhui,China;Effects of Edaravone on Pulmonary Function during One-lung Ventilation in Elderly Patients[J];Chinese Journal of General Practice;2013-02
9 HE Keqiang, WANG Ruiting , XIE Zhiqiong, PAN Jianhui, CHAI Xiaoping Department of Anesthesiology, the Affiliated Provincial Hospital of Anhui Medical University, Hefei 230001, China;Effects of Sevoflurane Postconditioning on Lung Function in Patients Undergoing Cardiac Valve Replacement with Cardiopulmonary Bypass[J];Tianjin Medical Journal;2013-07
10 LIU Min-xiao1,REN Fang-ying,HAO Li-ying,WANG Yong,XU Hong-meng (1 Fourth Hospital,Hebei Medical University,Shijiazhuang 050035,P.R.China);Influence of different patterns of one lung ventilation on lung injury in patients with esophageal carcinoma operation[J];Shandong Medical Journal;2013-13
【Secondary Citations】
Chinese Journal Full-text Database 9 Hits
1 CHANG Jia-song,WEI Kai-feng,XU De-guo(Nanjing University of Chinese Medicine,Nanjing 210029,Jiangsu,China);Effect of Shengjiang Powder on Expression of ICAM-1 of Lung Tissue Cells in Acute Lung Injury Rats[J];Journal of Liaoning University of Traditional Chinese Medicine;2008-01
2 DENG Jin-song,WEI Hua,ZHANG Ri-ying,et al.Department of Anesthesiology,Gaozhou People's Hospital,Guangdong 525200,China;Application of Improved Management of Breathe and Lung Protection in Minimally Invasive Cardiac Surgery for Children[J];Applied Journal of General Practice;2008-06
3 GUO Zhengming1,CHEN Yi2,LIU Huijun2,XIAO Yuequn1,SONG Haipeng1,WANG Zhaozhao1,QU Xiaolin1,LUO Ziqiang2(1.Department of Basic Science,Hunan Traditional Chinese Medicine College,Zhuzhou Hunan 412012;2.Department of Physiology,Xiangya School of Medicine,Central South University,Changsha 410078,China);Ginkgo biloba extract (Ginaton) attenuates acute lung injury induced by lipopolysaccharide in mice[J];International Journal of Pathology and Clinical Medicine;2009-04
4 ZHU Jun-chao,MA Hong,WANG Jun-ke(Dept of Anesthesiology,the First Affiliated Hospital,China Medical University,Shenyang 110001,China);Effects of sevoflurane pretreatment on the nuclear factor kappa B-DNA binding activity of leukocyte in peripheral blood of the patients undergoing cardiac valve replacement with cardiopulmonary bypass[J];Chinese Pharmacological Bulletin;2009-03
5 CHEN Yu-pei1,XIANG Xu-jin1,MIN Su2 (1. Dept of Anesthesiology,the Second Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400010,China; 2. Dept of Anesthesiology,the First Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400016,China);Effect of ranolazine postconditioning on the reperfusion injurysalvage kinase and mitochondrial permeability transition pore against ischemia-reperfusion injury in isolated rat heart[J];Chinese Pharmacological Bulletin;2010-01
6 YOU Zhi-jian,YAO Shang-long,LI Jin(Department of Anesthesiology,Xiehe hospital,Tongji Medical College,HuazhongUniversity of Science and Technology,Wuhan 430022,China);Comparison of Three Types of One-Lung Ventilation Models in Rabbits[J];Acta Laboratorium Animalis Scientia Sinica;2007-04
7 SUN Yan-hong (?) Yong WANG Jun-ke Department of Anes(?)siology,Frist Affi(?) (?) of (?) Medical University,Shenyang 110001,China;Effects of sevoflurane on endotoxin-induced oxidative stress response of the lungs in rats[J];Chinese Journal of Anesthesiology;2006-08
8 SUN Yan hong,ZHANG Qian,WANG Jun ke,CUI Yong Department of Anesthesiology,First Affiliated Hospital of China Medical University,Shenyang 110001,China;Effects of sevoflurane on membrane permeability of alveolar capillaries in rats with acute lung injury caused by endotoxin[J];Chinese Journal of Surgery;2004-16
9 GU Da-yong,LIANG Bing,TANG Xu-dong,et al.Science Laboratory,Number 401 Hospital of PLA,Shandong Qingdao 266071,China. Clinical Experimental Institute,Chendu Army General Hospital of PLA,Sichuan Chendu 610083,China;A Research on Expression of ICAM-1 and Adhesion to PMN of PMVEC Directly-Induced by LPS[J];Journal of Chinese Microcirculation;2006-01
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