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《Chinese Journal of Zoonoses》 2011-03
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Expression of major histocompatibility complex-Ⅱ on mouse cryptosporidiosis

QIN Yuan-hua,ZHENG Li-li,DAI Xiao-dong,REN Yi-xin,CUI Yu(Department of Parasitology,Dalian Medical University,Dalian 116044,China)  
To observe the treating function of Fructus Psoraleae and dihydroartemisinin on mouse infected with Cryptosporidium parvum and to research the regulating function of major histocompatibility complex-Ⅱ,60 mice were randomly divided into five groups: normal group A;positive control group-Ⅰ B;one-week treatment group C;positive control group-Ⅱ D;two-week treatment group E.Mice in group B,C,D,and E were injected subcutaneously with dexamethasone.When the mice were infected with C.parvum,they were treated with the medicine respectively.The intestine tissue was observed via HE.The expression of MHC-Ⅱ were observed by immunohistochemistry.The damaged intestine got improved and repaired,and a significant decrease of the amount of C.parvum oocysts in feces was shown in the treated groups(C,E) compared with positive control groups(B,D)(P0.05).In 1-week treatment group,the MHC-Ⅱ expression of group B was higher than that of normal group A.There was no difference between the expression of MHC-Ⅱ in group B and that in group C;in 2-week treatment group,there was no difference between the expression of MHC-Ⅱ in group E and that in group A.The MHC-Ⅱ expression of group D was lower than that of group A and B(P0.05).It's suggested that fructus Psoraleae and dihydroartemisinin are effective to treat mouse cryptosporidiosis.The expression of MHC-Ⅱ might be regulated by the mixture.
【Fund】: 辽宁省教育厅科学研究计划资助项目部分资金(No.2004D103)
【CateGory Index】: R392
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