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An outbreak of nosocomial neonatal diarrhea caused by enterotoxigenic Escherichia coliO128:H45

WANG Hong1,ZHAO Ai-lan2,BAI Xiang-ning2,ZHANG Zheng-dong1,XU Lie-ying1, CUI Min-li1,LIU Xiang1,JI Lü1,YE Chang-yun2,XIONG Yan-wen2,LI Qun1(1.Zigong Center for Disease Control and Prevention,Zigong 643000,China; 2.State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention,Beijing102206,China)  
To recognize the etiology of nosocomial neonatal diarrhea,the pathogens from feces of diarrheal neonates,anal swab of health care workers,and milk and environmental samples in NICU wards were screened.The results showed that Escherichia coli O128∶H45 strains were isolated from 12 fecal and 1 environmental samples.All 13 isolates contained the heat-stable enterotoxin gene st and showed the highly similar PFGE patterns,the same MLST sequence type(ST2332),and the similar antibiotic resistance spectrum.It could be concluded that the neonatal diarrhea outbreak in hospitals was caused by enterotoxigenic Escherichia coli O128∶H45.
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