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《Journal of Fishery Sciences of China》 2001-03
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Residues of furazolidone, sulfadiazine and norfloxacin in soft turtle, Trionyx sinensis

ZHU Qiu-hua, QIAN Guo-ying (Department of Life Sciences, Zhejiang Wanli College, Ningbo 315101, China)  
The soft turtle, Trionyx sinensis, body weight 235~319g, were fed the diets containing furazolidone(10 -4 , 10 -3 , 3×10 -3 ), sulfadiazine(10 -4 , 10 -3 , 3×10 -3 ) or norfloxacin(10 -5 , 10 -4 , 3×10 -4 ), for 7 and 14 d respectively. The experiment water temperature was (30±1)℃. The blood and 3 other tissues, i.e.liver, kidney and muscle, were analyzed at hour 24, 72, 120 and 240 after withdraw medication. The results showed that furazolidone was absorbed too little to be detected; the residual sulfadiazine could be detected in the 4 samples but the highest level was observed in the blood at hour 24 after the withdraw, and then dropped rapidly to the lowest level at hour 72 and vanished at hour 240, and norfloxacin was the samilar case in its residual change. The effect of administered time was not obvious on residue level in blood but that's not the case in the other 3 tissues that the residual levels went up with the elapse of administered time (P0.05). The residual elimination was the slowest in muscle that the residue rate was 76.8%(1.65~2.37 μg/kg) at hour 120 and 25%(0.63~1.11 μg/kg) at hour 240 for sulfadiazine, and for norfloxacin, 46%(0.81~0.93 μg/kg) at hour 120 and 24.2%(0.35~0.44 μg/kg) at hour 240 (the percentage was on the basis of the residue levels at hour 24 after withdraw). It is suggested that the sulfadiazine- or norfloxacin-treated soft turtle be onto the market 10 d after withdraw medication.
【Fund】: 浙江省重点攻关项目资助 ( 99110 2 2 5 3 0 0 2 )
【CateGory Index】: S948
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