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《Chinese Journal of Practical Pediatrics》 2008-01
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Studies on the relationship between astrocyte and clinical appearance in neonatal hypoxic-ischemic encephalopathy

WU Hui,WANG Dong-xuan,GAO Yu-xian,et al.Department of Piediatrics,The First Hospital of JiLin University,Changchun 130021,China  
Objective To observe the relationship between the change of astrocyte and clinical appearance in neonatal hypoxic-ischemia encephalopathy (HIE).Methods The pathological brain specimens of 25 newborn who died of HIE were observed macroscopically and microscopically.The immunochemistry staining with GFAP was used to observe the change of astrocyte.The relationship between astrocyte and the occurrence of HIE,course of disease and newborn degree of maturity were further synthetically analysed.Results The brain specimens of 25 newborn HIE have different-degreed astrocyte hyperplasia,Cerebellar hyperplasia show that hyperplasia is severe in the cases who dead within 24 hours(P0.05),the longer survived time the less hyperplasia it showed.Cerebral and medulla oblongata astrocyte hyperplasia is independent of survival time.Cerebral astrocyte hyperplasia in the chronic incomplete hypoxia cases are severe(P0.05); the change of medulla oblongata in the acute complete hypoxia cases are severe(P0.05).the change of cerebral cortex and medulla oblongata are all severe in the cases of mixed hypoxia(P0.05).Conclusion The degree of astrocyte hyperplasi are closely related to the occurrence and course of disease in HIE.
【CateGory Index】: R722.12
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【Secondary References】
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