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《Chinese Journal of Experimental Traditional Medical Formulae》 2007-01
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The Effect of Shen Shuai KeLi on Endothelin and Nitric Monoxide in Patients with Chronic Renal Failure

WANG Xiao-juan,LEI Ying,GUO Jian-sheng,GUO Xuan,HU Fang(The First Affiliated Hospital,TCM University of Hunan,Changsha 410007,China)  
Objective:To observe the effect of Shen Shuai KeLi on endothelin(ET) and nitrogen monoxide(NO)of chronic renal failure(CRF).Method:60 patients with CRF were randomly divided into two groups.30 patients in treatment group were treated with ShenShuai KeLi;the other 30 patients in control group were treated with oxyamyli tectus aldehydum.The blood urea nitrogen(BUN),serum creatinins(Scr),NO,ET and creatinine clearance rate(Ccr) were detected in both groups.Results:Compared with those in control group,the BUN,Cr,ET in treatment group decreased significantly(P0.01),and the NO,Ccr in treatment group increased significantly(P0.01).Conclusion:ShenShuai KeLi can decrease the BUN,ET,and Scr and increase NO and Ccr in patients with chronic renal failure,so it may delay the progress of chronic renal failure.
【Fund】: 湖南省卫生厅中医药科研基金资助(202020)
【CateGory Index】: R285.6
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