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《Chinese Journal of Experimental Traditional Medical Formulae》 2007-11
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Study on the Depressant Effect of Compound Qingre Granule-Serum on Extended-Spectrum Beta-Lactamase

YANG Jun~(1),ZHANG Shu-wen~2,YIN Cheng-hong~2,WANG Hong~2,REN Ai-min~2,ZHANG Li-xia~2,WANG Chao~2,WANG Bao-en~2(1.Critical Care Medicine Department,China Armed Police Force Gen Hospital,Beijing 100039,China;2.Infection and Critical Care Medicine Department,Beijing Friendship Hospital Affiliate of Capital University of Medical Sciences,Beijing 100050,China)  
Objective:To observe the depressant effect of the Compound Qingre Granule-Serum(SQ)on extended-spectrum beta-lactamase(ESBLs).Methods:According to ultraviolet spectrophotometry,different concentration SQ's β-lactamase inhibiting effect was determined.The effect was tested by changes of optical density in ultraviolet light induced by ampicillin.Results:33.3% SQ can inhibit the β-lactamase effect of ATCC700603 more than 50%,and had significant difference to control group.The β-lactamase inhibiting effect of SQ also showed positive correlation with its concentration.Conclusion:SQ can inhibit the action of ESBLs significantly.It may be one of the mechanisms of the granule for curing drug-resistance bacteria infections.
【Fund】: 北京市重大科技项目(H020920070091);; 北京市自然基金项目(7052026);; 北京市中医药科技项目(2005)
【CateGory Index】: R285.5
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