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《Chinese Journal of Experimental Traditional Medical Formulae》 2011-04
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Intestinal Absorption of Shikonin in Rats by in Situ Single Pass Perfusion Method

SU Hong1,HUANG Chuan-sheng1,CHEN Wen1,WANG Xin-chun2,1(1.Pharmacy of college,Shihezi University,Shihezi 832002,China;2.the first affiliated hospital of medical college,Shihezi University,Shihezi 832008,China)  
Objective:To study the in situ intestinal absorption behaviors of shikonin in rats.Method:The in situ rat single-pass intestinal perfusion model was used and the concentrations of the perfusate were determined by UV to investagate the intestinal absorption site and mechanism.Result:The Ka and Pappof shikonin showed colon jejunum duodenum ileum in four different region of rat intestine.The Ka and Papp of every segment had no signifi-cant different from the others.The Ka and Papp of different drug concentration had no significant influence.Conclu-sion: Shikonin could be absorbed in whole intestinal segment,the best intestinal absorption site was colon.Its ab-sorbing mechanism may be related to passive diffusion.
【Fund】: 石河子大学科学技术研究发展计划-高层次人才科研起动资金专项(RCZX-2007-79);; 国家科技部课题重大基础研究前期研究专项(2004CCA02300)
【CateGory Index】: R285.5
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