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《Chinese Journal of Experimental Traditional Medical Formulae》 2012-01
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Meta-Analysis of Traditional Chinese Medicine Plus Chemotherapy in Treatment of Postoperative Gastric Cancer

SHI Guo-jun1,SHAN Guang-zhi1,ZHOU Yi-qiang2,YANG Hua-feng3(1.Ningbo Hospital of Traditional Chinese Medicine,Ningbo 315010,China;2.Tumor Branch Association of Chinese Medicine,Beijing 100029,China;3.Ningbo Women and Children Hospital,Ningbo 315012,China)  
To evaluate the efficacy and safety of traditional Chinese medicine(TCM)in treating postoperative gastric cancer.We searched CNKI,VIP,WanFang(2001 to 2010) for randomized control trials about traditional Chinese medicine plus chemotherapy in the treatment of postoperative gastric cancer.Trial screening,quality assessment of included trials,and data extract were conducted.Statistical analysis was conductedby using RevMan 5.0 software.A total of 21 randomized controlled trials were included,meta analysis showed,① KPS score has 10 RCTs.5 RCTs of classification variables no heterogeneity,KPS score2.35,95%CI(1.78,3.10),P0.01],5 RCTs of continuous variables no heterogeneity,KPS score,the differences are significant.② Immune function 5 RCTs have heterogeneity and use random effects model.CD3CD4,CD4/CD8.The differences are significant.③ Survival 3 RCTs have no heterogeneity,and use fixed effects model.One year survival rate is,2 year survival rate,3 year survival rate.The differences are significant.④ Gastrointestinal reaction 5 RCTs have no heterogeneity,and use fixed effects model.Bad appetite above Ⅱ degrees is,Nausea and vomiting above Ⅱ degrees are.The differences are significant.⑤ Blood toxicity 7 RCTs have no heterogeneity,and use fixed effects model.Leucopenia reduce above Ⅱ degrees,HB reduce above Ⅱ degrees,PLT reduce above Ⅱ degrees.The differences are significant.Traditional Chinese medicine plus chemotherapy is effective in curing postoperative gastric cancer.It can improve KPS score,immune function and survival rate,and reduce gastrointestinal reaction and blood toxicity.But the quality of studies is low,more large-scale multi-center randomized trials are needed.
【CateGory Index】: R735.2
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