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Effects of Polysaccharides Extracted from Radix Codonopsis Lanceolatae on Blood Glucose and Immune Function in Rats Diabetes with Mellitus

ZHANG Feng*,GAO Yong-feng,ZHANG Ji-guo (Deptment of Pharmacology,Taishan Medical College,Taian 271016,China)  
Objective: To study the effects of polysaccharides extracted from Radix Codonopsis Lanceolatae(PCL) on blood glucose and immune function in rats with diabetes mellitus(DM).Method: The rat DM model was established by alloxan injected intraperitoneally.The therapy group rats were administrated PCL at 0.1 or 0.5 g·kg-1 dose.The level of fasting blood glucose was detected by enzyme-chemical method on the 0,7,14,21 day of PCL therapy;the body weight and weight of thymus and spleen were measured for spleen and thymus index;lymphocyte proliferation was observed by MTT method for stimulation index(SI).Result: Compared with normal control group,the level of fasting blood glucose of DM model group significantly increased(P0.01),3 weeks later,the thymus extremely withered,spleen lymphocyte transformation ability obviously decreased(P0.01).Compared with DM model group,PCL could observably reduce blood glucose after 2 weeks treatment(P0.05).3 weeks later,thymus index of PCL therapy group enhanced significantly(P0.05,P0.01),and SI increased obviously in the high dose PCL therapy group.Conclusion: PCL can decrease the level of fasting blood glucose in DM rats,meanwhile,cellular immune function can be improved significantly.
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