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《Chinese Journal of Experimental Traditional Medical Formulae》 2012-08
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Effect of Compatibility on Intestinal Absorption of Alkaloids in Fructus Evodiae and Rhizoma Coptidis in Rats

ZOU Li-juan1,CHEN Ying2,YANG Qing2,LI Yu-jie2,WANG Yi-wei2, WENG Xiao-gang2,DONG Yu3,MEN Wei1,ZHU Xiao-xin1,2(1.Capital Medical University School of Traditional Chinese Medicine,Beijing 100069,China; 2.Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China; 3.Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)  
Objective:To study the effect of compatibility with Fructus Evodiae on intestinal absorption of alkaloids in Rhizoma Coptidis and its mechanism in rats.Method: In situ single-pass perfused rat intestinal model was used and the concentrations of berberine and palmatine were determined by HPLC.The drug absorption rate constant(Ka) and apparent absorption coefficient(Papp) were tested to evaluate the effect of compatibility with verapamil or Fructus Evodiae on their absorption.Result: Rhizoma Coptidis extractive and Fructus Evodiae extractive(6∶12) can significantly enhance Ka and Papp of berberine and palmatine.Two alkaloids in Rhizoma Coptidis and Fructus Evodiae extractive(6∶12) promoted their intestine absorption.When the compatible proportion was 6∶1,the absorption of berberine decreased,and the absorption of palmatine increased.Verapamil had a promoting effect on the absorption of berberine and palmatine.Conclusion: Fructus Evodiae extractive can promote the intestine absorption of berberine and palmatine,and the mechanism may be related to its inhibition of P-glycoprotein activity.
【Fund】: 国家科学自然基金重点项目(30930114);; 国家科技重大专项(2009ZX09301-005-09);; 中国中医科学院基本科研业务费自主选题项目(ZZ20090101);; 国家国际科技合作专项(2011DFA30870)
【CateGory Index】: R284.1;R285
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