Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Experimental Traditional Medical Formulae》 2012-08
Add to Favorite Get Latest Update

Effect of Compatibility on Intestinal Absorption of Alkaloids in Fructus Evodiae and Rhizoma Coptidis in Rats

ZOU Li-juan1,CHEN Ying2,YANG Qing2,LI Yu-jie2,WANG Yi-wei2, WENG Xiao-gang2,DONG Yu3,MEN Wei1,ZHU Xiao-xin1,2(1.Capital Medical University School of Traditional Chinese Medicine,Beijing 100069,China; 2.Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China; 3.Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)  
Objective:To study the effect of compatibility with Fructus Evodiae on intestinal absorption of alkaloids in Rhizoma Coptidis and its mechanism in rats.Method: In situ single-pass perfused rat intestinal model was used and the concentrations of berberine and palmatine were determined by HPLC.The drug absorption rate constant(Ka) and apparent absorption coefficient(Papp) were tested to evaluate the effect of compatibility with verapamil or Fructus Evodiae on their absorption.Result: Rhizoma Coptidis extractive and Fructus Evodiae extractive(6∶12) can significantly enhance Ka and Papp of berberine and palmatine.Two alkaloids in Rhizoma Coptidis and Fructus Evodiae extractive(6∶12) promoted their intestine absorption.When the compatible proportion was 6∶1,the absorption of berberine decreased,and the absorption of palmatine increased.Verapamil had a promoting effect on the absorption of berberine and palmatine.Conclusion: Fructus Evodiae extractive can promote the intestine absorption of berberine and palmatine,and the mechanism may be related to its inhibition of P-glycoprotein activity.
【Fund】: 国家科学自然基金重点项目(30930114);; 国家科技重大专项(2009ZX09301-005-09);; 中国中医科学院基本科研业务费自主选题项目(ZZ20090101);; 国家国际科技合作专项(2011DFA30870)
【CateGory Index】: R284.1;R285
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 10 Hits
1 CHEN Yan-fen 1,CHEN Wei-wen 2, LI Ru-liu 2(1.Section of Chinese Materia Medica Pharmacology, Guangdong College of Pharmacy, Guangzhou, Guangdong 510240; 2.Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong 510405);Experiment of Zuojin Pills and Retro-ZuoJin by prescription corresponding to syndrome method[J];Academic Journal of Guangdong College of Pharmacy;2004-05
2 BI Hui-chang 1, GUAN Su 1, CHEN Xiao 2, QI Hui-min 3, SU Qi-biao 1, HUANG Min 1 (1. Institute of Clinical Pharmaco- logy, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510080, China; 2. Department. of Pharmacy, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China; 3. Institute of Clinical Pharmacology, Peking University, Beijing 100083, China);Experimental study on the absorption mechanism of cryptotanshinone single-pass intestinal perfusion model[J];The Chinese Journal of Clinical Pharmacology;2005-02
3 DONG Yu 1,ZHANG Ying-feng3,YANG Qing2,WANG Yi-wei2,ZHU Xiao-xin2(1.Guang’anmen Hospital,Institute of Chinese Materia Medica,Beijing 100053,China;2.China Academy of Chinese Medical Sciences,Institute of Chinese Materia Medica,Beijing 100700,China;3.Guangzhou University of Chinese Medicine,Guangzhou 510006,China);Absorption of the different compatibility of extractive Wujiwan by everted gut sacs model[J];Chinese Pharmacological Bulletin;2010-10
4 CHEN Xin-min,LI Jun-song,LI Wen,HAN Lei,LIU Xun-hong,DI Liu-qing,CAI Bao-chang (School of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210046,China);Intestinal absorption of the effective components of Schisandra chinensis Baill by rats single-pass perfusion in situ[J];Acta Pharmaceutica Sinica;2010-05
5 ZHANG Xin-feng,QIU Fu-rong,JIANG Jian,GAO Cheng-lu,HE Min(Department of Clinical Pharmacology,Shuguang Hospital Affiliated to Shanghai University of TCM,Shanghai 201203,China);Simultaneous determination of 6 alkaloids in Zuojin Pill and Xianglian Pill by LC-MS/MS[J];Chinese Traditional Patent Medicine;2010-04
6 LI Guo-feng,SUN Ya-bin,YANG Ling,YANG Li,LIU Si-jia,CHEN Zhi-liang(Pharmaceutical Department of Nanfang Hospital,Southern Medical University,Guangdong Guangzhou 510515,China);Effect of Labrasol on the permeabilities of paclitaxel,a p-gp substrate across the rat intestinal membranes in vitro[J];Chinese Journal of Hospital Pharmacy;2009-08
7 ZHANG Ying-feng2,LI Yu-jie1,YANG Qing1,WENG Xiao-gang1,DONG Yu3,ZHU Xiao-xin1(1.Institute of Chinese Materia Medica,China Academy of Chinese Medical Science,Beijing 100700,China;2.The Guangzhou University of Traditional Chinese Medicine,Guangzhou 510006,China;3.Guang’anmen Hospital,China Academy of Chinese Medical Science,Beijing 100053,China);Intestine Absorption Study on Danshensu and Salvianolic Acid B with Rat in situ Single Pass Perfusion Model[J];Chinese Journal of Experimental Traditional Medical Formulae;2010-11
8 CHEN Xi-ping,ZHANG Xiao-dan,DENG Zhong-jia(Department of Chengdu University of Tracditional Chinese Medicine Formula,Chengdu 610075,China);Compatibility Controlling Function of Huanglian[J];Chinese Journal of Experimental Traditional Medical Formulae;2011-04
9 TU Yao-sheng,SUN Dong-mei,ZENG Xiao-hui,CHEN Yu-xin,HUANG Xue-jun(Guangdong Province Institute of Tradition Chinese Medicine,Guangzhou 510095,China);Study on Rat Intestinal Absorption of Match-pair of Coptis-Evodia[J];Chinese Journal of Experimental Traditional Medical Formulae;2011-11
10 LI Juan1,LI Xiao-dong2,YANG Li-xia2,JIANG Hua2(1.Gansu Provincial People's Hospital,Lanzhou 730000,China; 2.Gansu academy of traditional Chinese medicine,Lanzhou 730050,China);Experimental Research of Single Herb Medicine in vitro Antibacterial Activity[J];Chinese Journal of Experimental Traditional Medical Formulae;2011-11
Chinese Journal Full-text Database 10 Hits
1 Zhang Jianguo,Su Yonghua Changhai Hospital of Second Military Medical University,Shanghai(200433);Research Developments on Dosage Form and Pharmaco-function of Cinobufagin[J];Journal of Zhejiang University of Traditional Chinese Medicine;2009-04
2 JIANG Jun1,2,JIA Xiao-bin2,3,LU Xiao-hui2,LI Wei2,YANG Guang-ming3,CAI Bao-chang3,WU Hao3 (1Zhenjiang Entry-Exit Inspection and Quarantine Bureau,State Key Laboratory of Food Additive and Condiment Testing,Zhenjiang 212008,China;2Key Laboratory of New Drug Delivery System of Chinese Meteria Medica,Jiangsu Provincial Academy of Chinese Medicine,Nanjing 210028,China;3Key Laboratory of Processing of Chinese Materia Medica,Nanjing University of Chinese Medicine,Nanjing 210029,China);Empirical study of Fructus Evodiae processed Rhizoma Coptidis’s synergistic effect on breadboard gastric ulcer of rats[J];China Journal of Traditional Chinese Medicine and Pharmacy;2010-12
3 ZHANG Xin-feng,QIU Fu-rong,JIANG Jian,GAO Cheng-lu (Key Laboratory for TCM Disesse and Syndrome of Liver and Kidney Disease of Ministry of Education,Pharmacokinetics laboratory,Shuguang Hospital Affiliated to Shanghai Chinese Medical University,Shanghai 201203,China);Comparative study of transport character of jatrorrhizine,coptisine,palmatine and berberine in Zuojin Wan and its similar formulae in Caco-2 cells[J];China Journal of Traditional Chinese Medicine and Pharmacy;2011-05
4 MI WeiTeaching and Research Section of Hygienics,Binzhou Medical University,Yantai 264003;Study of gastrodia elata blume on immune functions in mice[J];Journal of Binzhou Medical University;2010-04
5 ZHU Zhuang-chun1,SHI Xiang-guo2,ZHANG Shu-jie1,JIANG Guang-jiang1,XING Zhao-bin1,ZHAO Ya-long1,LI Zhan-jun1,WU Peng1(1.Department of Biological Sciences,North China Coal Medical College,Tangshan 063000,China;2.Douhe Reservoir Management,Tangshan 063000,China);In Vitro Antibacterial Activity of Chinese Herbs to Pathogenic Edwardsiella tarda Isolated from Flounder(Paralichthys olivaceus)[J];Fisheries Science;2007-05
6 LIU Jia,SHAN Anshan,XU Liangmei,WANG Anqi(Institute of Animal Nutrition,Northeast Agricultural University,Harbin 150030,China);Effect of Ligustrum lucidum of original powder on growth performance and immunity of broilers[J];Journal of Northeast Agricultural University;2009-12
7 ;全天麻胶囊对冠心病患者使用单硝酸异山梨酯所致头痛的影响[J];Contemporary Medicine;2010-01
8 LI Yong-mei, YANG Hai-wen, LUO Ren Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;Gene cloning,expression and purification of fusion protein epidermal growth factor-linker-trichosanthin[J];Journal of Southern Medical University;2007-02
9 PENG Qiu-xian1,YANG Da-jian2,SHI Jue3,CAI Hong-bing1,MO Zhi-xian1 1School of Traditional Chinese Medicine,Southern Medical University,Guangzhou 510515,China;2State Key Laboratory of Traditional Chinese Medicine and Molecular Pharmacology,Shenzhen 518057,China;3Center for Quantitative System Biology,Hong Kong Baptist University,Hong Kong,China;Proportion of Coptidis rhizoma and Evodiae fructus in the compound preparation:its effect in inducing apoptosis of SGC-7901 cells[J];Journal of Southern Medical University;2011-02
10 GAO Fu-hong,SUN Jian,WU Guo-juan(Animal Scientific Department,Beijing Agricultural College,Beijing,102206,China);Discussion of the Study on the Antitumor Mechanism of Trichosanthin[J];Progress In Veterinary Medicine;2005-11
China Proceedings of conference Full-text Database 2 Hits
1 ;Study on in situ Intestinal Absorption of Salvianolic acid B in Rats[A];[C];2008
2 Ying Liu,Zhi Qiang Chen,Xin Zhang,Nian Ping Feng.Ji Hui Zhao,Wu Shan and Tan Rong Department of Pharmaceutics,School of Pharmacy,Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road,Shanghai,201203,P.R.China;An Improved Formulation Screening and Optimization Method Applied to the Development of a Self-microemulsifying Drug Delivery System[A];[C];2009
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Bian Caimiao,Yang Yunbin,Fei Jie,et al College of Life Science,Taizhou University,Zhejiang Province ( 317000);Elementary Study on the Inhibition Effect of the Extracts from Schisandra Chinensis (Turcz.) Baill against the Bacteria in Vitro[J];Journal of Zhejiang University of Traditional Chinese Medicine;2009-01
2 Guo Shungen(Beijing College of Traditional Chinese Medicine, Bejing);Autoradiographic Study in the Distribution of ~3H-Tetramethyl-Pyrazine in Mice[J];;1989-03
3 ZHOU Xun,LI Gui-ming(The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China);Studies on antibacterial activity of different preparations of 10 kinds of Chinese traditional medicine in vitro-experiment[J];China Journal of Traditional Chinese Medicine and Pharmacy;2009-02
4 GUAN Shu-yu1,LIN Jia-qin1,ZENG Yu1,LIU Guang-feng2 (1.College of Traditional Chinese Medicine,Guangdong Pharmaceutical University,Guangzhou,Guangdong 510006;2.South China Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Guangzhou,Guangdong 510300,China);Study of the anti-bacteria activity of the extracts from the leaves of five herbs[J];Journal of Guangdong College of Pharmacy;2008-03
5 YU CHen; ZHANG Hui; REN Jian-Ying; (Shanghai Xu Hui District Central Hospital, Shanghai 200031)PAN Jun-Fang; HONG You-Cai; ZHU Da-Yuan; XU Xiu-Rong (Shanghai Institute of Materia Medica, Academia Sinica, Shanghai 200031);Determination and Preliminary Studies of Metabolism of Berberine in Human Urine After Oral Administration[J];THE CHINESE JOURNAL OF CLINICAL PHARMACOLOGY;2000-01
6 YUAN Yuan,JIANG Xue-hua ,ZHOU Jing , YANG Jun-yi,WANG Cai-qin West China School of Pharmacy ,Sichuan University,Chengdu 610041,China;THE ABSORPTION MECHANISM OF TANSHINONⅡ_A IN RAT SMALL INTESTINE[J];West China Journal of Pharmaceutcal Sciences;2002-04
7 TAO Sheng-Yuan①,LIU Yu-Bo,CHE Hui,JIN Shou-Dong (①Institute for Drug and Instrument Control of PLA,Beijing 100071 China);Content Determination of Berberine Hydrochloride in Jiawei Xianglian Water Pills by HPLC[J];Pharmaceutical Journal of Chinese People's Liberation Army;2009-03
8 Guo Shungen ; Ben Chang'en ; Zhao Liyun ; et al.(Beijing University of TCM, Beijing 100029);Quantitative Dynamic Study on the Whole-Body Autoradiography and Image Analysis of  ̄3H-Gardenoside in Rats and the Relationship of the Channel Tropism[J];JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE;1996-04
9 WU Chao,GUO Weiying (Liaoning Medical University,Jinzhou 121001 China);Liver Targeting Study on Glycyrrhetinic Acid Derivatives Modifying Norcantharidin Liposomes in Rats[J];Journal of Liaoning Medical University;2008-06
10 XU Xian-jin,MAO Qian,LIU Sheng-gui,LI Sheng-hua,NIU You-ya,ZHANG Jian(Department of Bioengineering,Huaihua University,Huaihua 418008,Hunan,China);Studies on Antibacterial Activity of Potentilla Discolor Bge.[J];Liaoning Journal of Traditional Chinese Medicine;2007-09
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved