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《Chinese Journal of Experimental Traditional Medical Formulae》 2012-11
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Hypotensive Effect of the Alcohol Extract from Gouteng Prescription on Spontaneous Hypertensive Rats

SONG Xue-yun*(The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine,Changsha,410007,China)  
Objective:To explore the hypotensive effects and mechanisms of the alcohol extract from Gouteng prescription.Method: Thirty spontaneous hypertensive rats(SHR) were randomly divided into five groups,untreated control,the high,middle,low dosage group of the alcohol extract and captopril group,six rats in each group.Tail blood pressure was measured every week.Rats were sacrificed to determine serum(NO),ET,AngⅡ after six weeks of treatment.Result: The alcohol extract from Gouteng prescription significantly lowered the blood pressure of rats,meanwhile significantly increased NO content,decreased markedly the content of ET,but it could not decrease AngⅡ.Conclusion:Alcohol extract from Gouteng prescription had significant hypotensive effect in SHR and its mechamsim may relate to increasing NO content and reducing ET level.
【CateGory Index】: R285.5
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