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《Chinese Journal of Experimental Traditional Medical Formulae》 2012-13
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Study on Chemical Constituents and Genotoxicity of Volatile Oil in Artemisia argyi from Gansu

LAN Mei-bing,YU Yong-li,LU Wei,LIU Mao-sheng,ZHENG Yan-fang,YANG Hui-ying,LI Xiao-hong(Department of Human Anatomy and Histo-Embryology,Zunyi Medical College Zhuhai Campus,Zhuhai 519041,China)  
Objective:To analyze the main chemical constituents of volatile oil in Artemisia argyi from Gansu,and explore its genotoxicity in mice.Method:①Constituents analysis: the chemical constituents of volatile oil in A.argyi were separated and identified by GC-MS,the relative content of each component was determined by area normalization.②Micronucleus assay: thirty Kunming pregnant mice were randomly divided into 5 groups: normal control group,ig given with peanut oil in equal volume;volatile oil 2,1,0.5 mL·kg-1 groups,ig given volatile oil;and positive control group,ip given cyclophosphamide(CP) 40 mg·kg-1.The normal control group and volatile group were ig administrated once a day from the 12th day of pregnancy to the 16 th day,for 5 d,while positive control group was ip given CP on the 15th day of pregnancy for 2 d.On the 16th day,the pregnant mice in each group were sacrificed to take out the embryo from mice,micronucleus test of adult mice bone marrow cells and fetal mice hepatocytes were carried out.③Sperm abnormality assay: forty male mice were randomly divided into 5 groups,the doses and administration of each group were similar to micronucleus test.The drugs was administered for 5 days.After 35 d of first medication,the mice were sacrificed to take out the epididymis and produce the sperm smear,and examination of sperm deformity was carried out.Result: Seventy-two components were isolated from volatile oil and fifty-six of them were identified,which was about 90.83% of all components.Compared with control group,the micronucleus rates of bone marrow and fetal hepatic cell and teratospermia number were all significantly increased(P0.05) at a oral dose of 2 mL·kg-1;only the micronucleus rate on fetal liver was increased significantly(P0.05) with the oral dose of 1 mL·kg-1;there was no statistic difference in any of the indexes at the dose of 0.5 mL·kg-1.Conclusion: The main chemical components of volatile oil in A.argyi from Gansu are 1,8-cineole(20.45%),artemisia alcohol(12.12%),camphor(6.99%),Artemisia ketone(5.85%),L-borneol(4.27%),et al.A potential dose-related genotoxicity of volatile oil in A.argyi has been verified in this research.
【Fund】: 遵义医学院中青年科研启动基金(F-0905) 遵义医学院珠海校区科研启动基金(F-0603)
【CateGory Index】: R285.5;R284
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【References】
Chinese Journal Full-text Database 4 Hits
1 JING Tao;YANG Guang-zhao;CHENG Shou-ren;YAO Yong;YU Cui-lan;SHEN He-jun;LIU Ye-lan;Nanjing Sports Institute;Basic Department of Nanguang College, Communication University of China;Nanjing University of Chinese Medicine;;Effects of Artemisia Argyi Moxibustion Therapy “Yizhichan” on Sleep, Attention Ability and TCM Constitution of Athletes Suffering Chronic Fatigue Syndrome[J];中国中医药信息杂志;2015-08
2 DING Manni;School of Humanities and Social Science,University of Chinese Academy of Sciences;;Morphology and chemical constituents of seven plants in item Folium Artemisiae Argyi in Chinese Materia Medica[J];吉林中医药;2015-05
3 HAO Peng-fei;ZHANG Li-fang;ZHANG Chao-yun;HUANG Xian-zhang;Nanyang Institute of Technology;;Comparative Analysis GC-MS of Artemisiae Argyi Folium Volatile Oil Extracted by SPME and SFE[J];中国实验方剂学杂志;2014-23
4 WANG Yong-li;WEI Xiao-hui;ZHAO Sen-miao;LIU Wei;LI Si-meng;CHOU Gui-xin;WANG Zheng-tao;Institute of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine; the MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines; Shanghai R&D Centre for Standardization of Chinese Medicines;;Content Determination of 3-Hydroxybenzoic Acid in Artemisiae Argyi Folium (Carbonized and Processed with Vinegar) by HPLC[J];中国实验方剂学杂志;2013-18
【Citations】
Chinese Journal Full-text Database 10 Hits
1 LAN Mei-bing,LI Xiao-hong,JIANG Hui-cai,ZHANG Hong,YU Yong-li(Department of Human Anatomy and Histology and Embryology,Zhuhai Campus Zunyi Medical College,Zhuhai 519041,China);Developmental toxicity of volatile oil from Artemisia argyi on skeleton of embryo mice[J];中国药理学与毒理学杂志;2010-06
2 SUN Rong1 WANG Hui2 HUANG Wei2 CHI Xue-jie3 MIAO De-yu2(1Shandong Research Academy of TCM,Shandong Jinan 250014,China;2Shandong University of Traditional Chinese Medicine,Shandong Jinan 250355,China;3Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China);Experimental Comparison Study on Mice's Acute Toxicity of Different Composition in Folium Artemisiae Argyi[J];中国药物警戒;2010-07
3 LIU Hongjie1,BAI Yang2,HONG Yanlong3,ZHANG Xun1 (1.Medical college of Jinan University,Guangzhou 510632,China;2.Guangzhou Institute of Biomedicine and Health,Chinese Academy of Sciences,Guangzhou 510663,China;3.Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China);Component analysis and acute hepatotoxicity of volatile oils from argy wormwood leaf extracted by different methods[J];中国中药杂志;2010-11
4 ZHOU Ci-li,TAN Lin-ying,WANG Xiao-mei,MA Xiao-peng,QI Li,QIN Xiu-di,LIU Hui-rong,WU Huan-gan.Shanghai Research Institute of Acupucture and Meridian,Shanghai 200030,China;Investigation of the Biological Effects and Influential Factors of Mugwort Chemical Components[J];上海针灸杂志;2010-02
5 JIANG Ping-chuan~*,LI Jia,LIANG Jiang-chang(Guangxi Institution of Chinese Medicine & Pharmaceutical Science,Nanning 530022,China);Study on Chemical Constituents of the Volatile Oil from Artemisia argyi of Guangxi by GC/MS[J];中国实验方剂学杂志;2009-12
6 SUN Rong1,HUANG Wei2,WANG Hui2 1Shandong Academy of Chinese Medicine(Shandong Jinan 250014,China) 2Shandong University of Traditional Chinese Medicine(Shandong Jinan 250355,China);Research Development on Chemical Compositions of Folium Artemisiae Argyi Related with Efficacy and Toxicity[J];中国药物警戒;2009-11
7 LAN Mei-bing,YU Yong-li,LI Xiao-hong(Department of Human Anatomy and Histology and Embryology,Zunyi Medical College Zhuhai Campus,Zhuhai 519041,China);Analysis on the chemical constituents of the essential oil of Artemisia argyi Levl. et Vant. in Guizhou[J];药物分析杂志;2009-08
8 HU Yi-xiu,LIU Xiu-ying,YI Chuan-zhu,et al.Hunan Provincial Center for Disease Control and Prevention,Changsha 410005,China;Study on the Acute Toxicity and Genetic Toxicity of Water Extracts from Momordica Charantia[J];中国预防医学杂志;2008-02
9 HU Jian-ping~(1,2),LIU Chun-fang~1,LIN Na~1(1.Institute of Chinese Materia Madica,China Academy of Chinese Medical Sciences,Beijing 100700,China;2.Jiangxi Academy of Traditional Chinese Medicine,Nanchang 330077,China);Application of Modern Technology in Heredity Toxicity of Traditional Chinese Drugs[J];中国实验方剂学杂志;2006-08
10 LI Xiaohong,YANG Liu,JI Keping,et al.Gansu College of Traditional Chinese Medicine,department of Anatomy and Histology & department of Gynicology of Traditional Chinese Medicine & department of Biology,Lanzhou 730000,China;Study of Chinese drug Arnebia genotoxicity with micronucleus test[J];中国生育健康杂志;2003-03
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Liang Guilan;Ge Hai;Yin Guilan;Gulou Hospital Affiliated to Medical College of Nanjing University;;Application of portable moxibustion combined with hirudoid in autogenous internal arteriovenous fistula in hemodialysis patients[J];国际护理学杂志;2016-03
2 ZHANG Tingting;ZHAO Ya;WANG Nianhong;School of Acupuncture and Massage of Shanghai University of Traditional Chinese Medicine;Rehabilitation Medical School of Binzhou Medical University;Rehabilitation Medical Department of Huashan Hospital Affiliated to Fudan University;;Research on the Safety of Moxa Smoking[J];西部中医药;2015-12
3 LIU Hongjie;LI Tianhao;ZHAN Sha;CHEN Lingxiu;CUI Huiying;CHEN Qingshan;Department of Traditional Chinese Medicine,Medical College,Jinan University;Department of Epidemiology,Medical College,Jinan University;;Research of Four Properties,Five Flavors and Channel Tropism on Predicting Hepatotoxicity of Chinese Herbal Medicines[J];中药新药与临床药理;2015-05
4 Chen Guiqin;Li Guisheng;Luo Xiang;Analysis and Testing Research Institute of Jiangxi Province;;Simultaneous Determination of Four Volatile Components in Artemisia Argyi by Gas Chromatography[J];化学分析计量;2015-04
5 WANG Yang;XIANG Rong-wu;TIAN Bai-hui;SUN Guo-xiang;School of Pharmacy,Shenyang Pharmaceutical University;School of Medical Devices ,Shenyang Pharmaceutical University;;The differences of the Bliss four models in calculating the median reaction dose and the therapeutic index[J];沈阳药科大学学报;2015-06
6 DING Manni;School of Humanities and Social Science,University of Chinese Academy of Sciences;;Morphology and chemical constituents of seven plants in item Folium Artemisiae Argyi in Chinese Materia Medica[J];吉林中医药;2015-05
7 Zhang Peng;Xie Peizhen;Yang Zhuohong;Cheng Jianhua;Xie Mingrong;Zheng Huasheng;Guangzhou Chaohui Chemical Technology Co., Ltd.;South China Agricultural University, College of Science;;Advances in Mugwort Oil as Natural Antibacterial Agent[J];广东化工;2015-08
8 Zhou Ci-li;Lu Yuan;Wu Lu-yi;Liu Hui-rong;Cui Yun-hua;Zhao Ji-meng;Li Jing;Zhou Zhi-gang;Wu Huan-gan;Shanghai Research Institute of Acupuncture and Meridian, Shanghai University of Traditional Chinese Medicine;Shanghai University of Traditional Chinese Medicine;Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine;Jiangxi University of Traditional Chinese Medicine;;Urine metabonomics of moxibustion products in rats[J];中国组织工程研究;2015-15
9 ZHANG Xiaojun;ZHAO Zhihong;WANG Guifang;ZHANG Zhuangli;ZOU Min;CHEN Huiping;Pharmaceutical Chemistry Room, Academy of Medical and Pharmaceutical Sciences of Zhengzhou University;;Comparison of volatile constituents from Artemisiae argyi Folium by HSSPME-GC-MS with other methods[J];中国医药导报;2015-09
10 SHENG Ping;TANG Daiping;MIAO Lijuan;ZHAN Yujiao;SUN Yun;WANG Yanjiao;WANG Guoping;Xinjiang Key Laboratory of Famous Prescription and Science of Formulas;School of Traditional Chinese Medicine, Xinjiang Medical University;;GC-MS Fingerprints of Essential Oils of Ferula Ferulaeoides from Different Habitats[J];中国现代应用药学;2015-01
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 BAI Yi;DU Li-na;FENG Xue;JIN Yi-guang;China Pharmaceutial Newspaper;Department of Pharmaceutical Sciences,Beijing Institute of Radiation Medicine;;Progress of Transdermal Drug Delivery Systems for Natural Drugs[J];中国药学杂志;2014-16
2 ZHANG Chao;HAN Li;ZHANG Ding-kun;ZHANG Fang;HAO Yue-pu;Chengdu University of Traditional Chinese Medicine (TCM) Key Laboratory of System Research and Development of TCM Resources;;Research Progress on Penetration Methods and its Combination of Transdermal Drug Delivery System[J];中国实验方剂学杂志;2014-07
3 CAI Rong-lin;HU Ling;LI Zi-hui;LI Meng;CHENG Hong-liang;WU Zi-jian;Anhui University of CM;Acupuncture and Moxibustion Hospital of Anhui Province;;Effects of warming moxibustion on scores of fatigue and life quality in patients with subhealth fatigue status[J];World Journal of Acupuncture-Moxibustion;2014-01
4 CAI Rong-lin;HU Ling;LI Zi-hui;LI Meng;CHENG Hong-liang;WU Zi-jian;HU Wu-bin;Anhui University of Traditional Chinese Medicine;Acupuncture Hospital of Anhui Province;Anhui Provincial ,TCM Hospital;;Sub-health fatigue patients treated with mild moxibustion: A randomized controlled trial[J];中华中医药杂志;2014-03
5 LI Qing-zheng1,XU Xin-bao2,LI Zeng-min3 1.Beijing Institute of Sport Science,Beijing 100050,China;2.Jiaozuo Teachers College,Jiaozuo 454000,China;3.Qinghai University for Nationalities,Xining 810007,China.;Analysis on Fatigue Diagnosis of Athletes in Different Training Cycle[J];体育科学;2013-07
6 JIN Ran1,YU Mi-mi2,ZHAO Bai-xiao1,LIU Bin1,FU Xin-tong2,CHEN You-gen2,GUO Hong-zhu2(1.Beijing University of Chinese Medicine,Beijing 100029,China;2.Beijing Institute for Drug Control,Beijing 100035,China);GC content determination of four volatile components from Artemisia argyi *[J];药物分析杂志;2013-06
7 YU Feng-rui1,SUN Li-li2,DAI Yan-peng2,ZHOU Qian2(1.Shandong University of Traditional Chinese Medicine,Ji'nan 250014,China; 2.Shandong Academy of Chinese medicine,Ji'nan 250014,China);Optimization of Processing Technology for Artemisia argyi Carbonisatus with Vinegar[J];中国实验方剂学杂志;2012-14
8 LAN Mei-bing,YU Yong-li,LU Wei,LIU Mao-sheng,ZHENG Yan-fang,YANG Hui-ying,LI Xiao-hong(Department of Human Anatomy and Histo-Embryology,Zunyi Medical College Zhuhai Campus,Zhuhai 519041,China);Study on Chemical Constituents and Genotoxicity of Volatile Oil in Artemisia argyi from Gansu[J];中国实验方剂学杂志;2012-13
9 Liu Mei-feng1,2 Zhou Hui1(1.School of Chemistry and Chemical Engineering,South China University of Technology,Guangzhou 510640,Guangdong,China; 2.Guangdong Provincial Key Lab for Green Chemical Product Technology,South China University of Technology,Guangzhou 510640,Guangdong,China);Comparison of Chemical Constituents Between Essential Oil and Smog from Artemisia argyi[J];华南理工大学学报(自然科学版);2012-01
10 SHI Lin et al(Department of Food and Bioengineering,Guangdong Industry Technical College,Guangzhou,Guangdong 510300);Effect of Different Extraction Methods on the Chemical Constituents of Essential Oils from FOLIUM ARTEMISIAE ARGYI[J];安徽农业科学;2011-35
【Secondary References】
Chinese Journal Full-text Database 2 Hits
1 XU Jun-jie;LU Jin-qing;GUO Sheng-nan;WAN Li-juan;Research and Development Center of Medicinal Plant in Hubei Province,Hubei University of Chinese Medicine;;GC-MS Analysis of Chemical Components of Essential Oil from Artemisia argyi in Different Parts and Different Harvest Periods[J];中国实验方剂学杂志;2015-21
2 FU Ruo-nong;School of Chemistry,Beijing Institute of Technology;;Development of solidphase microextraction(SPME) in recent years[J];分析试验室;2015-05
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 SUN Rong1,HUANG Wei2,WANG Hui2 1Shandong Academy of Chinese Medicine(Shandong Jinan 250014,China) 2Shandong University of Traditional Chinese Medicine(Shandong Jinan 250355,China);Research Development on Chemical Compositions of Folium Artemisiae Argyi Related with Efficacy and Toxicity[J];中国药物警戒;2009-11
2 LAN Mei-bing,YU Yong-li,LI Xiao-hong(Department of Human Anatomy and Histology and Embryology,Zunyi Medical College Zhuhai Campus,Zhuhai 519041,China);Analysis on the chemical constituents of the essential oil of Artemisia argyi Levl. et Vant. in Guizhou[J];药物分析杂志;2009-08
3 WU Huai-en, LI Yao-hua, WEI Zhi-ying, LIANG Hai-yan (Guangxi Traditional Chinese Medical University, Nanning 530001, China);A comparative study on the chemical constituents of volatile oil from Artemisia indica, Artemisia feddei and Artemisia argyi in Guangxi Province[J];中国医药导报;2008-35
4 ZHAN Zhong-gen (Zhejiang Economic & Trade Polytechnic, Hangzhou 310018);Effects of anti-active oxygen free radicals of flavonoids and analysis of fatty acids by GC-MS from Artemisia vulgaris L[J];食品科技;2008-11
5 YANG Hua1,TIAN Rui1,LI Yan2,SONG Yan-wei1,CHEN Bing-xu3,(1.College of Chemistry and Chemical Engineering,Yan'an University,Yan'an 716000,China;2.South China Agriculture University,Key Laboratory of Pesticide and Chemical Biology Ministry of Education,Guangzhou 510642;3.Plant Protection Research Institute,Guangdong Academy of Agricultural Sciences,Guangzhou 510640,China);Studies on the chemical components of volatile oil from Folium artemisise Argyi of northern Shanxi[J];广东农业科学;2008-11
6 Xu Xin-Jian Song Hai Xue Guo-qin An Hong-gang Wu Dong-qing (Key Laboratory of Resources and Environment Chemistry of West China,Zhangye Gansu 734000;Department of Chemistry,Hexi University,Zhangye Gansu 734000);Analysis of Chemical Constituents of Volatile Oil from Artemisia Argyi with Different Methods[J];河西学院学报;2008-05
7 WU Na,SUN Zhi-da (College of Food Science and Technology,Huazhong Agricultural University,Wuhan 430070,China);Study on Antioxidant Activity in vitro and Protection Against DNA Oxidative Damage of Flavonoids of Artemisia argyi[J];食品科学;2008-10
8 Research Center of Analysis & Test (HE Zheng-you,ZHANG Yan-hong,WEI Dong,YU Rong-hua,LAN Min-bo),Key Laboratory for Ultrafine Material of Ministry of Education (YUAN Hui-hui,LAN Min-bo),East China University of Science and Technology,Shanghai 200237,China;Chemical composition of essential oils extracted from Folium Artemisiae argyi by three different methods[J];中国医药生物技术;2008-04
9 YAN Ze-qun,ZHANG Xiu-lan (College of Chemistry and Chemical Engineering,Xinyang Normal University,Xinyang 464000,China);Studies on Chemical Components of Essential Oils from Folium Arte Misiae Argyi[J];信阳师范学院学报(自然科学版);2008-02
10 LI Zi-min,HE Ai-tao,WU Cheng-qiu,et al.School of Public Heath,Nanhua University(Hengyang 421001,China);Developmental toxicity effect of benzene on embryo mouse forelimb buds[J];中国公共卫生;2008-04
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