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《Chinese Journal of Experimental Traditional Medical Formulae》 2012-19
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Progress on Study of Buxus alkaloids

LV Xia1*,YU Xu2,GUO Qing3,MA Yu-qin4(1.Lianyungang Traditional Chinese Medicine Branch,Jiangsu Union Technical Institute,Lianyungang 222007,China;2.Institute of Botany,Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014,China;3.Jiangsu Institute for Food and Drug Control,Nanjing 210008,China; 4.Lianyungang Environmental Monitoring Center Station,Lianyungang 222001,China)  
To summarize the research progress of chemical structures and biological activities of Buxus alkaloids,which are rich in plants of genus Buxus and provide useful references for the further research.Literature about Buxus alkaloids between 1992 to 2011 in plenty of journals and books were referred to,and the progress of chemical structures and biological activities were summarized.Since 1992,more than 100 alkaloids have been isolated from 8 kinds of plants of genus Buxus.Many researches suggested some of Buxus alkaloids exhibit biological activities including anti-HIV activity,antibacterial,antimycobacterial,antimalarial,antitumor,and inhibitory activities against acetylcholinesterase(AChE),butyrylcholinesterase(BuChE) and glutathione S-transferase(GST).There are more than 70 kinds of plants of genus Buxus all over the world,but only a minority of them has been studied at present.And little research about biological activities of Buxus alkaloids have been reported.In order to develop the medicinal application of the genus of plants,chemical constituents together with pharmacological activities and mechanism should be conducted.Meanwhile,the biological effects and the medical value compounds will be clarified.
【CateGory Index】: R284.1
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