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《Chinese Journal of Experimental Traditional Medical Formulae》 2012-21
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Optimization of Naodesheng Dispersible Tablet Prescription and Its in vitro Release Evaluation

GUO Yu-yan,YANG Hai-ling,LV Shao-wa,XIA Chang,LI Yong-ji(Heilongjiang University of Chinese Medicine,Harbin 150040,China)  
Objective:To optimize molding process of Naodesheng dispersible tablet,and to evaluate its in vitro release.Method:With disintegration time and formability as indexes,kind and ratio of accessories from Naodesheng dispersible tablet were screened by single factor test and orthogonal test;With puerarin as detection index,in vitro release comparative evaluation of Naodesheng dispersible tablet and Naodesheng ordinary tablet was determined by dissolution method.Result:Optimum preparation technology was as follows:with CaSO4 as filler,95% ethanol as adhesive,combined disintegrating agent of 5% microcrystalline cellulose-5% PVPP-5% croscarmellose sodium and 0.5% HPC,hardness of 6-7 kg was suitable for this dispersible tablet;Dissolution rate of Naodesheng dispersible tablet was more than 80% in 10 min and 90% in 15 min,dissolution rate of Naodesheng ordinary tablet was far below 50% within 10 min and less than 80% in 45 min,but dissolution rate of Naodesheng dispersible tablet was 94.65% in 45 min.Conclusion:Preparation process of Naodesheng dispersible tablet was stable,simple and feasible,its in vitro release effect was significantly better than Naodesheng ordinary tablet.
【Fund】: 黑龙江中医药大学面上基金项目(2010006);; 黑龙江省中医药管理局项目(ZHY12-2073)
【CateGory Index】: TQ461;R286
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