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Effects of Acanthopanax senticosus on Immune Function and Anti-fatigue Ability in Sleep Deprivated Mice

XU Guang-hui1 ,WU Yan-ping2,LUO You-hua1,HUANG Yi-qi1,LI Ting-li3(1.Xiamen Medical Research Institute,Xiamen 361008,China; 2.Fujian University of Chinese Medicine,Fuzhou 350000,China; 3.Heilongjiang University of Chinese Medicine,Harbin 150040,China)  
Objective:To study the effects of Acanthopanax senticosus(500,1 000 mg · kg-1) on immune function and anti-fatigue ability in sleep deprivated mice.Method: Sleep-deprivated mice model was induced by single platform technique,the immune function of sleep-deprivated mice was tested by the clearance rate of charcoal particles and the level of serum,and anti-fatigue ability was measured by the weight-loaded swimming method and the rotated performance test.Result: A.senticosus could significantly enhance the clearing index and the correction clearing index of sleep deprivated mice,the time of loaded-swimming and the residence time on the rotated sticks deprivation mice were extended significantly.Conclusion: A.senticosus can increase immune functions and anti-fatigue ability of sleep deprivated mice.
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