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《Chinese Journal of Experimental Traditional Medical Formulae》 2013-06
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In vivo Intestinal Absorption Kinetics Study of Rhynchophylline and Isorhynchophylline of Tiangou Jiangya Capsules

LI Ji,LI Ling-jun,LOU Hua-wei(Shandong University of Traditional Chinese Medicine,Ji'nan 250355,China)  
Objective:To study in vivo intestinal absorption kinetics of rhynchophylline and isorhynchophylline of Tiangou Jiangya capsules.Method:HPLC method was used to determine the content of rhynchophylline,isorhynchophylline and Ultra-violet(UV)spectrophotometry was used to determine the content of phenol red in the rat in vivo intestinal perfusion tests.Result:The regression of rhynchophylline is Y=-0.331 7X-0.771 8(r=0.998 5),Ka=0.331 7(h-1),t1/2=2.09(h).The regression of isorhynchophylline is Y=-0.687 0X-0.150 4(r=0.985 2),Ka=0.687 0(h-1),t1/2=1.01(h).Conclusion:The absorption of rhynchophylline and isorhynchophylline of Tiangou Jiangya capsules in rat's intestine comply with the first-order kinetics process.
【Fund】: 国家十二五“重大新药创制”项目(2012ZX09102201-004)
【CateGory Index】: R285
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