Effect of Different Compatibility of Polygoni Cuspidati Rhizoma et Radix on Glucose,Lipid Metabolism and Blood Rheology in Diabetic Nephropathy Rats
WANG Hui1,YE Tong-sheng1,CHEN Su-hua1,LIU Yong-sheng2,MIAO Ming-san1,XIONG Wei-zheng3,ZHANG Bing4(1.Pharmacy College,Henan University of Traditional Chinese Medicine(TCM),Zhengzhou 450008,China;2.the Second Hospital,Henan University of TCM,Zhengzhou 450002,China;3.Henan Lingrui Pharmaceutical Co.,Ltd.,Xinxian 465550,China;4.Pharmacy College Beijing University of TCM,Beijing 100102,China)
Objective: To investigate the effect of the compatibility of Polygoni Cuspidati Rhizoma et Radix and Astragali Radix,Polygoni Cuspidati Rhizoma et Radix and Leonuri Herba on glucose,lipid metabolism and blood rheology in diabetic nephropathy rats.Method: Diabetic nephropathy was induced by streptozotocin(STZ) peritoneal injection with a dose of 60 mg.kg-1(the normal control group was excluded).Based on fasting blood-glucose(FBG) the rats were randomly divided into 4 groups: model group,Kaibotong group,Polygoni Cuspidati Rhizoma et Radix and Astragali Radix group,Polygoni Cuspidati Rhizoma et Radix and Leonuri Herba group.The drugs were given to rats daily for 8 consecutive weeks.At the end of the 2 nd,4 th,8 thweek,the rats were fasted after the last administration and then collected the blood samples,glucose oxidase(GOD) was used to examine the fasting blood glucose,trigluceride(TG),cholesterol(CHO),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C) were also tested,the blood rheology indexes were detected.Result: Compared with the model group,the treatment group could effectively restore the condition of diabetic nephropathy rat,the compatibility of Polygoni Cuspidati Rhizoma et Radix and Astragali Radix,Polygoni Cuspidati Rhizoma et Radix and Leonuri Herba could significantly reduce the levels of blood sugar and blood lipid,the difference was statistically significant(P 0.05 and P 0.01),andcould change the whole blood viscosity and plasma viscosity of the diabetic nephropathy rats,the difference was statistically significant(P 0.05 and P 0.01).Conclusion: Different compatibility of Polygoni Cuspidati Rhizoma et Radix demonstrates hypoglycemic and hypolipidemic effects,and can reduce the whole blood viscosity and plasma viscosity.
【Fund】： 河南省博士后科研启动资金;; 河南省科技攻关重点项目(102102310341);; 河南中医学院博士基金
【CateGory Index】： R285.5
【CateGory Index】： R285.5