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《Chinese Journal of Experimental Traditional Medical Formulae》 2013-17
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Anti-diabetic Activity of Amentoflavone in Selaginella tamariscina in Diabetic Mice

ZHENG Xiao-ke,SU Cheng-fu,ZHANG Li,GAO Ai-she,KE Ying-ying,YUAN Pei-pei,WANG Xiao-lan,ZHANG Xin,FENG Wei-sheng(Henan University of Traditional Chinese Medicine,Zhengzhou 450046,China)  
Objective:To study the anti-diabetic activity of amentoflavone(AMT) in diabetic mice,and to lay the foundation for the further research and development.Method:Male Kunming mice were injected intraperitoneally(ip) with streptozotocin(STZ,180 mg·kg-1) to induce diabetic model.Then,the diabetic mice were treated with AMT(30,60,120,240,480 mg·kg-1) for 2 weeks.During the administration,food and water intake was recorded.After administration for 2 weeks,the serum levels of fasting blood glucose(FBG),oral glucose tolerance test(OGTT) and insulin were measured,meanwhile pathologic-morphological of pancreas was observed by HE staining,to authenticate the antidiabetic activity of AMT and to find out the optimum dose.Result:All the dose of AMT(30,60,120,240,480 mg·kg-1) could decrease the food and water intake and FBG,and ameliorate the OGTT.Meanwhile,amentoflavone could improve islet tissue repair function.Conclusion:AMT can ameliorate the glucose disorder,regulate insulin secretion and restore the pancreas.
【Fund】: 国家自然科学基金项目(81073034);; 国家十二五“重大新药创制”科技重大专项(2013ZX09102-022)
【CateGory Index】: R285.5
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